Certain high blood pressure drugs block cancer invasion

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https://www.sciencedaily.com/releases/2016/12/1612...

Certain high blood pressure drugs block cancer invasion

Researchers have identified a new way of blocking the spread of cancer. Calcium channel blockers, which are used to lower blood pressure, block breast and pancreatic cancer invasion by inhibiting cellular structures.

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  • ElaineTherese
    ElaineTherese Member Posts: 3,328
    edited December 2016

    I'm on Amlodipine (Norvasc), a calcium channel blocker. Who knew that it might be useful against BC?

  • Nanpop
    Nanpop Member Posts: 75
    edited December 2016

    The study you have is a secondary source, not peer reviewed. It's in response to a connection of channel calcium blockers and breast cancer.


    Here is the primary research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49327...


    Drug companies don't want to go out of business.



  • barbe1958
    barbe1958 Member Posts: 19,757
    edited December 2016

    I've been on blood pressure meds for 23 years and developed both a primary and a recurrence of breast cancer.

  • KBeee
    KBeee Member Posts: 5,109
    edited December 2016

    There are a lot of classes of blood pressure meds, but not all are calcium channel blockers, which are the ones mentioned here. They typically are not the first line treatment, but I suppose if a doctor wants to put you on BP meds, you could ask for this class of drugs instead. Of course like everything, this targets just one area, so it won't work for everyone's cancer. Barbe, when you see your PCP, ask what kind BP drug you're on. You could have a discussion on whether switching to a calcium channel blocker would be appropriate.

  • barbe1958
    barbe1958 Member Posts: 19,757
    edited December 2016

    Kbee in my case it would be like closing the barn door after the horses have fled.

  • KBeee
    KBeee Member Posts: 5,109
    edited December 2016

    It would. I wonder, however, if it has the potential to help slow further spread. There are, of course, no studies to back that up, so it would just be about the pros and cons of switching to a different class of drugs than you're currently on (not sure what you're on; perhaps one is a calcium channel blocker) for the small chance it could have a side benefit. Like everything, the drugs have side effects and can interact differently with other drugs.

    I just filed it in my mind (and noted it on my notes on my phone) as something to remember if my docs ever want to put me on BP meds. I would not take one just for this potential effect, but if I have to choose one over the other, then that might sway my decision.

  • barbe1958
    barbe1958 Member Posts: 19,757
    edited December 2016

    I remember reading something BAD about BP meds and breast cancer years ago. Darned if I can remember what that was...

  • KBeee
    KBeee Member Posts: 5,109
    edited December 2016

    It's frustrating because it seems like the studies often show conflicting things........I suppose that's the nature of science, but it's frustrating when it directly impacts you.

  • Gracejoy
    Gracejoy Member Posts: 48
    edited December 2016

    Original article is below indicating what types of medications are the good ones for the inhibition of L-type calcium channels that block cancer cell invasion in vitro

    http://www.nature.com/articles/ncomms13297


    They say amlodipine besylate, felodipine, manidipine dichloride and cilnidipine which were demonstrated to significantly reduce the number of MYO10-induced filopodia in breast cancer cells as efficiently as a PI3K inhibitor (shown in Fig 1 a) therefore cancer cell invasion in cultured cells.

  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited December 2016

    Barbe, if you'll take a look at Nanpop's post above, the article she linked to discusses and explores the contradictory studies of the effect of hypertension drugs on breast cancer. The study presented is quite a large effort and, going by their results at least, should be reassuring.

  • barbe1958
    barbe1958 Member Posts: 19,757
    edited December 2016

    Holy cow. In this one thread we have link for BP meds being good AND one for them being bad!?!??!?

  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited December 2016

    Barbe, my reading of the NCBI link, above, is that it addresses the question of whether hypertension drugs add to risk of breast cancer and found, from their very large study, that the answer is NO.

  • barbe1958
    barbe1958 Member Posts: 19,757
    edited December 2016

    Oh. The title threw me. Thanks!

  • wallycat
    wallycat Member Posts: 3,227
    edited December 2016

    I had read that diuretics, which are typically first course treatment when initially diagnosed with hypertension, can increase risk of BC. That was a few years ago.

    You also need to remember than some BP meds increase risk of type 2 diabetes.
    Beta blockers are prime examples. There is one newer beta blocker that does not increase diabetes risk (carvedelol/Coreg).

    On this same back and forth, we had all been reading that NSAIDS decrease risk of BC recurrence and other cancers. Yesterday, I read that non-aggressive endometrial cancer has a worse prognosis for women who have taken NSAIDS for 10 or more years. And the really aggressive uterine cancer actually fares better. I hope they just wrote that article poorly.


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