Tamoxifen with Paxil?

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Hi all, has anyone heard of negative effects of Paxil with regard to breast cancer and reducing the efficacy of tamoxifen?  I've been taking Paxil for many years before bc.  After mastectomy and chemo, I took tamoxifen.  I switched to arimidex for 9 months and then back to tamoxifen for a total of 4 years--it has been very difficult as my side effects are nasty. 

I just heard that paxil negatively effects the efficacy of tamoxifen and should not be prescribed together.  Not only that, but the studies I've read about say the longer they are taken together the higher the risk of recurrence.  The reports I've read are from 2009.  I'm just 1 month short of my 5 year surgical anniversary.  Needless to say, my anxiety level is spiked and I feel like I've wasted the last five years.

A friend just went through a very, very early stage lumpectomy.  Radiation recommended, but she refused.  She is taking tamoxifen.  She said her doctor told her she might hear stories about anti-depressants with tamoxifen, but there is apparently new data that shows there is no issue with the combination.  I can't find anything out there about this new data and am anxious to know if anyone else has heard.


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