What is focal secretory change?

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Persistent530
Persistent530 Member Posts: 5
edited October 2016 in Benign Breast Conditions

Hi ladies, Tuesday I received my pathology report and it read: Benign breast tissue with focal secretory change with microcalcifications. My gyn was unsure of what it meant.So I'm scheduling an appointment with the breast surgeon because I also developed a lump that was not there after my sterotactic biopsy.

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  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited October 2016

    Here's one thing I found on Pubmed:

    The aetiology of focal, preganancy-like mammary changes in non-pregnant and non-lactating women is discussed on the basis of the literature and a material of 31 patients. Such changes were found in one or more glandular lobules in 3 per cent of the breast tissue specimens received in our departments. As a rule, this finding was made in women who had been pregnant and who had been or were on oestrogenic or on contraceptive medication. They occurred in fertile, menopausal, as well as in post-menopausal women. Often they were seen many years after the pregnancy and/or intake of hormones. They were observed also in women who had never been pregnant or on hormone medication, and even in men on oestrogen therapy. It is likely, therefore, that focal pregnancy-like changes in non-pregnant and non-lactating women indicate a selective susceptibility of the mammary glandular tissue to oestrogen. Accordingly, we interpret the change as a normal histological variant.

  • Persistent530
    Persistent530 Member Posts: 5
    edited October 2016


    Thank you MelissaDallas! I had been having a hard time trying to find any information about it.

  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited October 2016

    It's kind of interesting. I'll be curious to hear what the surgeon says. You'll have to update us

  • Persistent530
    Persistent530 Member Posts: 5
    edited October 2016

    Yes it is and I most definitely will.

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