Medicines that interfere with Hormonals - Tamoxifen

I signed up for "up-to-date" which is a doctor and med student subscription program that offers all the up to date medical advice as well as drug interactions. I wanted to share the list for anyone who didn't want to spend the money but was curious about the major players in drug interactions. This list is far more extensive than what Drugs.com gives you. This is a the current list for Tamoxifen. Rated A-X (A= no known interaction; B= no action needed). I'm not a doctor, so if you have any questions, it's best to ask your PCP about this list and what it means for you. and here's the disclaimer on the site:

Lexi-Comp's Comprehensive Drug-to-Drug, Drug-to-Herb and Herb-to-Herb Interaction Analysis Program

NOTE: Lexi-Interact does not address chemical compatibility related to I.V. drug preparation or administration.

Lexi-Interact Online combines the world's literature and scientific understanding of drug interactions with a state-of-the-art electronic platform, providing an efficient way to ensure that adverse drug events don't compromise the care of your patients.

Review all interactions for a selected medication or enter a patient specific regimen to analyze for potential interactions. Additionally, you may select a drug interaction result to obtain detailed information on Patient Management, Interacting Members, Risk Rating, References and more.

Risk Rating X: Avoid combination CYP2D6 Inhibitors (Strong) Interacting Members BuPROPion; Cinacalcet; Cocaine; Delavirdine; FLUoxetine; Lopinavir; Methotrimeprazine; PARoxetine; QuiNIDine; Ritonavir; Stiripentol; Terbinafine (Systemic); Thioridazine; Tipranavir

Risk Rating Consider therapy modification CYP2D6 Inhibitors (Moderate) Interacting Members Abiraterone Acetate; Amiodarone; Asunaprevir; Celecoxib; Chloroquine; ChlorproMAZINE; Cimetidine; CloBAZam; ClomiPRAMINE; CloZAPine; Darifenacin; Desipramine; DiphenhydrAMINE (Systemic); Dronedarone; DULoxetine; Eliglustat; Haloperidol; Imipramine; Isoniazid; Ketoconazole (Systemic); Lorcaserin; Lumefantrine; Methadone; Mirabegron; NiCARdipine; Nilotinib; Panobinostat; Perhexiline; QuiNINE; Rolapitant; Sertraline; Ticlopidine; Tranylcypromine

Risk Rating Consider therapy modification CYP3A4 Substrates Interacting Members Abiraterone Acetate; Alfuzosin; ALPRAZolam; Amiodarone; AmLODIPine; Apixaban; Apremilast; Aprepitant; ARIPiprazole; ARIPiprazole Lauroxil; Armodafinil; Artemether; Asunaprevir; Atazanavir; AtorvaSTATin; Avanafil; Axitinib; Barnidipine; Bedaquiline; Benzphetamine; Bisoprolol; Blonanserin; Boceprevir; Bortezomib; Bosutinib; Brexpiprazole; BusPIRone; Cabazitaxel; Cabozantinib; Calcitriol (Systemic); CarBAMazepine; Cariprazine; Ceritinib; ChlordiazePOXIDE; Chloroquine; Cilnidipine; Cilostazol; Citalopram; Clarithromycin; ClonazePAM; Clorazepate; Cobicistat; Cobimetinib; Conivaptan; Crizotinib; CycloSPORINE (Systemic); Cyproterone; Daclatasvir; Dantrolene; Dapsone (Systemic); Darifenacin; Darunavir; Dasatinib; Delavirdine; Dexamethasone (Systemic); DiazePAM; Dienogest; Digitoxin; DiltiaZEM; Disopyramide; DOCEtaxel; Doxazosin; DOXOrubicin (Conventional); DOXOrubicin (Liposomal); Dronedarone; Dydrogesterone; Ebastine; Efavirenz; Elbasvir; Eliglustat; Elvitegravir; Enzalutamide; Eplerenone; Erlotinib; Erythromycin (Systemic); Escitalopram; Estradiol (Systemic); Estradiol (Topical); Estrogens (Conjugated A/Synthetic); Estrogens (Conjugated B/Synthetic); Estrogens (Conjugated/Equine, Systemic); Estrogens (Conjugated/Equine, Topical); Estrogens (Esterified); Estrone; Estropipate; Eszopiclone; Ethinyl Estradiol; Ethosuximide; Etoposide; Etoposide Phosphate; Etoricoxib; Etravirine; Everolimus; Exemestane; Felbamate; Felodipine; Fesoterodine; Flibanserin; Flurazepam; Fosamprenavir; Fosaprepitant; Gefitinib; Grazoprevir; GuanFACINE; Halofantrine; Haloperidol; HYDROXYprogesterone Caproate; Ibrutinib; Idelalisib; Imatinib; Indinavir; Irinotecan (Conventional); Irinotecan (Liposomal); Isavuconazonium Sulfate; Isosorbide Dinitrate; Isosorbide Mononitrate; Isradipine; Itraconazole; Ivabradine; Ivacaftor; Ixabepilone; Ixazomib; Ketoconazole (Systemic); Lacidipine; Lansoprazole; Lapatinib; Lercanidipine; Levonorgestrel (Systemic); Lidocaine (Systemic); Linagliptin; Lomitapide; Losartan; Lovastatin; Lumefantrine; Lurasidone; Lynestrenol; Macitentan; Maraviroc; MedroxyPROGESTERone; Mefloquine; Mestranol; Methadone; Mianserin; Midazolam; MiFEPRIStone; Mirodenafil; Mirtazapine; Modafinil; Naloxegol; Nefazodone; Nelfinavir; Netupitant; Nevirapine; NiCARdipine; NIFEdipine; Nilotinib; Nilvadipine; NiMODipine; Nisoldipine; Nitrendipine; Norethindrone; Norgestrel; Olaparib; Ombitasvir, Paritaprevir, and Ritonavir; Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir; Ondansetron; Ospemifene; OxyCODONE; PACLitaxel (Conventional); PACLitaxel (Protein Bound); Palbociclib; Panobinostat; PAZOPanib; Perampanel; Pimozide; Pipotiazine; Praziquantel; Primaquine; Progesterone; QUEtiapine; QuiNIDine; QuiNINE; RABEprazole; Ranolazine; Regorafenib; Repaglinide; Rifabutin; Rilpivirine; Riociguat; Ritonavir; Rivaroxaban; Roflumilast; Rolapitant; RomiDEPsin; Ruxolitinib; Saquinavir; Sildenafil; Silodosin; Simeprevir; Simvastatin; Sirolimus; Solifenacin; Sonidegib; Spiramycin; Stiripentol; SUNItinib; Suvorexant; Tacrolimus (Systemic); Tamoxifen; Tamsulosin; Tasimelteon; Telaprevir; Telithromycin; Temsirolimus; Teniposide; Tetracycline; TiaGABine; Tibolone; Ticagrelor; Ticlopidine; Tipranavir; Tofacitinib; Tolterodine; Tolvaptan; Toremifene; Trabectedin; TraMADol; TraZODone; Triazolam; Trimethoprim; Trimipramine; Ulipristal; Vandetanib; Velpatasvir; Vemurafenib; Venetoclax; Venlafaxine; Verapamil; Vilazodone; VinBLAStine; VinCRIStine; VinCRIStine (Liposomal); Vortioxetine; Zolpidem; Zonisamide; Zopiclone Exceptions Buprenorphine; Etizolam; HYDROcodone

Risk Rating Consider therapy modification CYP3A4 Inducers (Strong) Interacting Members CarBAMazepine; Enzalutamide; Fosphenytoin; Lumacaftor; Mitotane; PHENobarbital; Phenytoin; Primidone; Rifabutin; RifAMPin; Rifapentine

Risk Rating C: Monitor therapy CYP3A4 Substrates Interacting Members Abiraterone Acetate; Alfuzosin; ALPRAZolam; Amiodarone; AmLODIPine; Apixaban; Apremilast; Aprepitant; ARIPiprazole; ARIPiprazole Lauroxil; Armodafinil; Artemether; Asunaprevir; Atazanavir; AtorvaSTATin; Avanafil; Axitinib; Barnidipine; Bedaquiline; Benzphetamine; Bisoprolol; Blonanserin; Boceprevir; Bortezomib; Bosutinib; Brexpiprazole; Buprenorphine; BusPIRone; Cabazitaxel; Cabozantinib; Calcitriol (Systemic); CarBAMazepine; Cariprazine; Ceritinib; ChlordiazePOXIDE; Chloroquine; Cilnidipine; Cilostazol; Citalopram; Clarithromycin; ClonazePAM; Clorazepate; Cobicistat; Cobimetinib; Conivaptan; Crizotinib; CycloSPORINE (Systemic); Cyproterone; Daclatasvir; Dantrolene; Dapsone (Systemic); Darifenacin; Darunavir; Dasatinib; Delavirdine; Dexamethasone (Systemic); DiazePAM; Dienogest; Digitoxin; DiltiaZEM; Disopyramide; DOCEtaxel; Doxazosin; DOXOrubicin (Conventional); DOXOrubicin (Liposomal); Dronedarone; Dydrogesterone; Ebastine; Efavirenz; Elbasvir; Eliglustat; Elvitegravir; Enzalutamide; Eplerenone; Erlotinib; Erythromycin (Systemic); Escitalopram; Estradiol (Systemic); Estradiol (Topical); Estrogens (Conjugated A/Synthetic); Estrogens (Conjugated B/Synthetic); Estrogens (Conjugated/Equine, Systemic); Estrogens (Conjugated/Equine, Topical); Estrogens (Esterified); Estrone; Estropipate; Eszopiclone; Ethinyl Estradiol; Ethosuximide; Etizolam; Etoposide; Etoposide Phosphate; Etoricoxib; Etravirine; Everolimus; Exemestane; Felbamate; Felodipine; Fesoterodine; Flibanserin; Flurazepam; Fosamprenavir; Fosaprepitant; Gefitinib; Grazoprevir; GuanFACINE; Halofantrine; Haloperidol; HYDROcodone; HYDROXYprogesterone Caproate; Ibrutinib; Idelalisib; Imatinib; Indinavir; Irinotecan (Conventional); Irinotecan (Liposomal); Isavuconazonium Sulfate; Isosorbide Dinitrate; Isosorbide Mononitrate; Isradipine; Itraconazole; Ivabradine; Ivacaftor; Ixabepilone; Ixazomib; Ketoconazole (Systemic); Lacidipine; Lansoprazole; Lapatinib; Lercanidipine; Levonorgestrel (Systemic); Lidocaine (Systemic); Linagliptin; Lomitapide; Losartan; Lovastatin; Lumefantrine; Lurasidone; Lynestrenol; Macitentan; Maraviroc; MedroxyPROGESTERone; Mefloquine; Mestranol; Methadone; Mianserin; Midazolam; MiFEPRIStone; Mirodenafil; Mirtazapine; Modafinil; Naloxegol; Nefazodone; Nelfinavir; Netupitant; Nevirapine; NiCARdipine; NIFEdipine; Nilotinib; Nilvadipine; NiMODipine; Nisoldipine; Nitrendipine; Norethindrone; Norgestrel; Olaparib; Ombitasvir, Paritaprevir, and Ritonavir; Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir; Ondansetron; Ospemifene; OxyCODONE; PACLitaxel (Conventional); PACLitaxel (Protein Bound); Palbociclib; Panobinostat; PAZOPanib; Perampanel; Pimozide; Pipotiazine; Praziquantel; Primaquine; Progesterone; QUEtiapine; QuiNIDine; QuiNINE; RABEprazole; Ranolazine; Regorafenib; Repaglinide; Rifabutin; Rilpivirine; Riociguat; Ritonavir; Rivaroxaban; Roflumilast; Rolapitant; RomiDEPsin; Ruxolitinib; Saquinavir; Sildenafil; Silodosin; Simeprevir; Simvastatin; Sirolimus; Solifenacin; Sonidegib; Spiramycin; Stiripentol; SUNItinib; Suvorexant; Tacrolimus (Systemic); Tamoxifen; Tamsulosin; Tasimelteon; Telaprevir; Telithromycin; Temsirolimus; Teniposide; Tetracycline; TiaGABine; Tibolone; Ticagrelor; Ticlopidine; Tipranavir; Tofacitinib; Tolterodine; Tolvaptan; Toremifene; Trabectedin; TraMADol; TraZODone; Triazolam; Trimethoprim; Trimipramine; Ulipristal; Vandetanib; Velpatasvir; Vemurafenib; Venetoclax; Venlafaxine; Verapamil; Vilazodone; VinBLAStine; VinCRIStine; VinCRIStine (Liposomal); Vortioxetine; Zolpidem; Zonisamide; Zopiclone

Risk Rating C: Monitor therapy CYP3A4 Inducers (Moderate) Interacting Members Bexarotene (Systemic); Bosentan; Dabrafenib; Efavirenz; Eslicarbazepine; Etravirine; Modafinil; Nafcillin; St John's Wort

Risk Rating C: Monitor therapy CYP3A4 Substrates Interacting Members Ado-Trastuzumab Emtansine; Alfentanil; Alfuzosin; ALPRAZolam; Amiodarone; AmLODIPine; Aprepitant; ARIPiprazole; ARIPiprazole Lauroxil; Asunaprevir; Atazanavir; AtorvaSTATin; Avanafil; Axitinib; Barnidipine; Blonanserin; Bosutinib; Brexpiprazole; Bromocriptine; Budesonide (Systemic); Buprenorphine; BusPIRone; Cabazitaxel; Cabozantinib; Calcitriol (Systemic); CarBAMazepine; Cariprazine; Ceritinib; ChlordiazePOXIDE; Chloroquine; Cilnidipine; Cilostazol; Cinacalcet; Cisapride; Citalopram; Clarithromycin; ClonazePAM; Cobimetinib; Colchicine; Conivaptan; Crizotinib; CycloSPORINE (Systemic); Cyproterone; Dabrafenib; Daclatasvir; Dapoxetine; Darifenacin; Darunavir; Dasatinib; Dexamethasone (Systemic); DiazePAM; Digitoxin; Dihydroergotamine; DiltiaZEM; Disopyramide; DOCEtaxel; Domperidone; Doxazosin; DOXOrubicin (Conventional); DOXOrubicin (Liposomal); Dronedarone; Dydrogesterone; Ebastine; Elbasvir; Eletriptan; Eliglustat; Eplerenone; Ergoloid Mesylates; Ergonovine; Ergotamine; Erlotinib; Erythromycin (Systemic); Escitalopram; Eszopiclone; Ethosuximide; Etizolam; Etoposide; Etoposide Phosphate; Everolimus; Felbamate; Felodipine; FentaNYL; Fesoterodine; Flibanserin; Flurazepam; Fluticasone (Oral Inhalation); Fosaprepitant; Gefitinib; Grazoprevir; GuanFACINE; Halofantrine; Haloperidol; HYDROcodone; HYDROXYprogesterone Caproate; Ibrutinib; Irinotecan (Conventional); Irinotecan (Liposomal); Isavuconazonium Sulfate; Isosorbide Dinitrate; Isosorbide Mononitrate; Isradipine; Itraconazole; Ivabradine; Ivacaftor; Ixabepilone; Ketamine; Lacidipine; Lapatinib; Lercanidipine; Levomilnacipran; Lidocaine (Systemic); Lidocaine (Topical); Lomitapide; Lovastatin; Lurasidone; Macitentan; Maraviroc; Mefloquine; Methadone; Methylergonovine; Midazolam; MiFEPRIStone; Mirodenafil; Mirtazapine; Naloxegol; Nefazodone; NiCARdipine; NIFEdipine; Nilotinib; Nilvadipine; NiMODipine; Nisoldipine; Nitrendipine; Olaparib; Ombitasvir, Paritaprevir, and Ritonavir; Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir; OxyCODONE; PACLitaxel (Conventional); PACLitaxel (Protein Bound); Palbociclib; Panobinostat; PAZOPanib; Pimavanserin; Pimozide; QUEtiapine; QuiNIDine; QuiNINE; Ranolazine; Reboxetine; Regorafenib; Ruxolitinib; Salmeterol; SAXagliptin; Sildenafil; Silodosin; Simeprevir; Simvastatin; Sirolimus; Solifenacin; Sonidegib; Spiramycin; Stiripentol; SUFentanil; SUNItinib; Suvorexant; Tacrolimus (Systemic); Tadalafil; Tamoxifen; Tamsulosin; Telaprevir; Telithromycin; Temsirolimus; Teniposide; TiaGABine; Tofacitinib; Tolterodine; Tolvaptan; Trabectedin; TraZODone; Triazolam; Trimipramine; Udenafil; Vardenafil; Vemurafenib; Venetoclax; Venlafaxine; Verapamil; VinBLAStine; VinCRIStine; VinCRIStine (Liposomal); Zopiclone ExceptionsAlitretinoin (Systemic); Praziquantel; Vinorelbine

Risk Rating C: Monitor therapy CYP3A4 Inhibitors (Moderate) Interacting Members Aprepitant; Conivaptan; Crizotinib; DiltiaZEM; Dronedarone; Erythromycin (Systemic); Fluconazole; Fosamprenavir; Grapefruit Juice; Imatinib; Isavuconazonium Sulfate; Netupitant; Nilotinib; Schisandra; Verapamil

Risk Rating Consider therapy modification CYP3A4 Substrates Interacting Members Ado-Trastuzumab Emtansine; Alfentanil; Alfuzosin; ALPRAZolam; Amiodarone; AmLODIPine; Aprepitant; ARIPiprazole; ARIPiprazole Lauroxil; Asunaprevir; Atazanavir; AtorvaSTATin; Avanafil; Axitinib; Barnidipine; Blonanserin; Bosutinib; Brexpiprazole; Bromocriptine; Budesonide (Systemic); BusPIRone; Cabazitaxel; Cabozantinib; Calcitriol (Systemic); CarBAMazepine; Cariprazine; Ceritinib; ChlordiazePOXIDE; Chloroquine; Cilnidipine; Cilostazol; Cinacalcet; Cisapride; Citalopram; Clarithromycin; ClonazePAM; Cobimetinib; Colchicine; Conivaptan; Crizotinib; CycloSPORINE (Systemic); Cyproterone; Dabrafenib; Daclatasvir; Dapoxetine; Darifenacin; Darunavir; Dasatinib; Dexamethasone (Systemic); DiazePAM; Digitoxin; Dihydroergotamine; DiltiaZEM; Disopyramide; DOCEtaxel; Domperidone; Doxazosin; DOXOrubicin (Conventional); DOXOrubicin (Liposomal); Dronedarone; Dydrogesterone; Ebastine; Elbasvir; Eletriptan; Eliglustat; Eplerenone; Ergoloid Mesylates; Ergonovine; Ergotamine; Erlotinib; Erythromycin (Systemic); Escitalopram; Eszopiclone; Ethosuximide; Etizolam; Etoposide; Etoposide Phosphate; Everolimus; Felbamate; Felodipine; FentaNYL; Fesoterodine; Flibanserin; Flurazepam; Fluticasone (Oral Inhalation); Fosaprepitant; Grazoprevir; GuanFACINE; Halofantrine; Haloperidol; HYDROXYprogesterone Caproate; Ibrutinib; Irinotecan (Conventional); Irinotecan (Liposomal); Isavuconazonium Sulfate; Isosorbide Dinitrate; Isosorbide Mononitrate; Isradipine; Itraconazole; Ivabradine; Ivacaftor; Ixabepilone; Ketamine; Lacidipine; Lapatinib; Lercanidipine; Levomilnacipran; Lidocaine (Systemic); Lidocaine (Topical); Lomitapide; Lovastatin; Lurasidone; Macitentan; Maraviroc; Mefloquine; Methadone; Methylergonovine; Midazolam; MiFEPRIStone; Mirodenafil; Mirtazapine; Naloxegol; Nefazodone; NiCARdipine; NIFEdipine; Nilotinib; Nilvadipine; NiMODipine; Nisoldipine; Nitrendipine; Olaparib; Ombitasvir, Paritaprevir, and Ritonavir; Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir; OxyCODONE; PACLitaxel (Conventional); PACLitaxel (Protein Bound); Palbociclib; Panobinostat; PAZOPanib; Pimavanserin; Pimozide; QUEtiapine; QuiNIDine; QuiNINE; Ranolazine; Reboxetine; Regorafenib; Ruxolitinib; Salmeterol; SAXagliptin; Sildenafil; Silodosin; Simeprevir; Simvastatin; Sirolimus; Solifenacin; Sonidegib; Spiramycin; Stiripentol; SUFentanil; SUNItinib; Suvorexant; Tacrolimus (Systemic); Tadalafil; Tamoxifen; Tamsulosin; Telaprevir; Temsirolimus; Teniposide; TiaGABine; Tofacitinib; Tolterodine; Tolvaptan; Trabectedin; TraZODone; Triazolam; Trimipramine; Udenafil; Vardenafil; Vemurafenib; Venetoclax; Venlafaxine; Verapamil; VinBLAStine; VinCRIStine; VinCRIStine (Liposomal); Zopiclone Exceptions Alitretinoin (Systemic); Buprenorphine; Gefitinib; HYDROcodone; Praziquantel; Telithromycin; Vinorelbine

Risk Rating Consider therapy modification CYP3A4 Inhibitors (Strong) Interacting Members Atazanavir; Boceprevir; Ceritinib; Clarithromycin; Cobicistat; Darunavir; Idelalisib; Indinavir; Itraconazole; Ketoconazole (Systemic); Lopinavir; MiFEPRIStone; Nefazodone; Nelfinavir; Ombitasvir, Paritaprevir, and Ritonavir; Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir; Posaconazole; Ritonavir; Saquinavir; Telaprevir; Telithromycin; Voriconazole

Risk Rating C: Monitor therapy CYP2C8 Substrates Interacting Members Amiodarone; Amodiaquine; Dabrafenib; Enzalutamide; Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir; PACLitaxel (Conventional); PACLitaxel (Protein Bound); Pioglitazone; Repaglinide; Rosiglitazone; Selexipag; Tretinoin (Systemic)

Risk Rating C: Monitor therapy CYP2C8 Inhibitors (Moderate) Interacting Members Celecoxib; Clopidogrel; Deferasirox; Efavirenz; Felodipine; Irbesartan; Lapatinib; Losartan; Nilotinib; Pioglitazone; QuiNINE; RABEprazole; Rosiglitazone; Tamoxifen; Teriflunomide; Trimethoprim

Risk Rating Consider therapy modification CYP2C9 Substrates Interacting Members Acenocoumarol; Benzbromarone; Celecoxib; ChlorproPAMIDE; Dapsone (Systemic); Etravirine; FLUoxetine; Fosphenytoin; Gliclazide; Glimepiride; GlipiZIDE; GlyBURIDE; Ketamine; Lesinurad; Losartan; Meloxicam; Mestranol; Nateglinide; Ospemifene; Phenytoin; Piroxicam; SulfADIAZINE; Sulfamethoxazole; Sulfinpyrazone; SulfiSOXAZOLE; Tamoxifen; TOLBUTamide; Torsemide; Trimethoprim; Voriconazole; Warfarin; Zafirlukast

Risk Rating Consider therapy modification CYP2C9 Inducers (Strong) Interacting Members Aprepitant; CarBAMazepine; Fosphenytoin; PHENobarbital; Phenytoin; Primidone; RifAMPin; Rifapentine; Secobarbital

Risk Rating Consider therapy modification CYP2C9 Substrates Interacting Members Acenocoumarol; Benzbromarone; Celecoxib; ChlorproPAMIDE; Dapsone (Systemic); FLUoxetine; Fosphenytoin; Gliclazide; Glimepiride; GlipiZIDE; GlyBURIDE; Ketamine; Lesinurad; Losartan; Meloxicam; Mestranol; Nateglinide; Phenytoin; Piroxicam; SulfADIAZINE; Sulfamethoxazole; Sulfinpyrazone; SulfiSOXAZOLE; Tamoxifen; TOLBUTamide; Torsemide; Trimethoprim; Voriconazole; Warfarin; Zafirlukast

Risk Rating Consider therapy modification CYP2C9 Inhibitors (Strong) Interacting Members Capecitabine; Delavirdine; Floxuridine; Fluorouracil (Systemic); Gemfibrozil; NiCARdipine; SulfADIAZINE; SulfiSOXAZOLE; Tegafur; TOLBUTamide

Risk Rating C: Monitor therapy CYP2C9 Substrates Interacting Members Acenocoumarol; Benzbromarone; Celecoxib; ChlorproPAMIDE; Dapsone (Systemic); FLUoxetine; Fosphenytoin; Gliclazide; Glimepiride; GlipiZIDE; GlyBURIDE; Ketamine; Lesinurad; Losartan; Meloxicam; Mestranol; Nateglinide; Phenytoin; Piroxicam; SulfADIAZINE; Sulfamethoxazole; Sulfinpyrazone; SulfiSOXAZOLE; Tamoxifen; TOLBUTamide; Torsemide; Trimethoprim; Voriconazole; Warfarin; Zafirlukast

Risk Rating C: Monitor therapy CYP2C9 Inhibitors (Moderate) Interacting Members Abiraterone Acetate; Amiodarone; Benzbromarone; Ceritinib; Efavirenz; Etravirine; Fluconazole; Fluvastatin; Irbesartan; Ketoconazole (Systemic); Leflunomide; Losartan; Milk Thistle; Omeprazole; Pyrimethamine; QuiNINE; SORAfenib; Sulfamethoxazole; Sulfinpyrazone; Trimethoprim; Voriconazole; Zafirlukast

[D] Abiraterone Acetate

[D] Afatinib

[X] Amodiaquine

[D] Anastrozole

[B] Apixaban

[D] Asunaprevir

[C] Bexarotene (Systemic)

[C] Bosentan

[X] Bosutinib

[C] Brentuximab Vedotin

[D] Colchicine

[X] Conivaptan

[D] Dabigatran Etexilate

[D] Dabrafenib

[C] Dasatinib

[C] Deferasirox

[B] Desvenlafaxine

[D] DOXOrubicin (conventional)

[D] Edoxaban

[D] Enzalutamide

[D] Everolimus

[C) Fosaprepitant

[X] Fusidic Acid (systemic)

[D] Highest Risk QTc-Prolonging Agents Interacting Members Ajmaline; Amiodarone; Anagrelide; Arsenic Trioxide; Artemether; Asenapine; Astemizole; Bepridil; Buprenorphine; Cisapride; Citalopram; Disopyramide; Dofetilide; Domperidone; Dosulepin; Dronedarone; Eliglustat; Escitalopram; FLUoxetine; Flupentixol; Halofantrine; Ibutilide; Iloperidone; Lopinavir; Lumefantrine; MiFEPRIStone; Nilotinib; Paliperidone; Pimavanserin; Pimozide; Pipamperone [INT]; Procainamide; QUEtiapine; QuiNIDine; QuiNINE; Sotalol; Sparfloxacin; Sulpiride; Terfenadine; Tetrabenazine; Thioridazine; Toremifene; Vandetanib; Vemurafenib; Vernakalant; Ziprasidone; Zuclopenthixol

[X] Idelalisib

[C] Ivacaftor

[C] Letrozole

[C] Luliconazole

[D] MiFEPRIStone

[C] Mipomersen

[D] Mitotane

[C] Moderate Risk QTc-Prolonging Agents Interacting Members Azithromycin (Systemic); Bedaquiline; Ceritinib; Chloroquine; ChlorproMAZINE; Ciprofloxacin (Systemic); Clarithromycin; CloZAPine; Crizotinib; Dolasetron; Droperidol; Erythromycin (Systemic); Flecainide; Gadobenate Dimeglumine; Gemifloxacin; Goserelin; Granisetron; Haloperidol; Lenvatinib; Leuprolide; LevoFLOXacin (Oral Inhalation); LevoFLOXacin (Systemic); Mequitazine; Methadone; Moxifloxacin (Systemic); Ofloxacin (Systemic); Ondansetron; Osimertinib; Panobinostat; PAZOPanib; Pentamidine (Systemic); Perflutren Lipid Microspheres; Primaquine; Propafenone; Roxithromycin; Saquinavir; Sodium Stibogluconate [INT]; Telavancin; Telithromycin; Terlipressin

[C] Nalozegol

[C] Netupitant

[C] Osimertinib

[X] Ospemifene

[C] P-glycoprotein/ABCB1 Substrates

[C] Palbociclib

[D] Panobinostat

[X] PAZOPanib

[C] Peginterferon Alfa-2b

[B] Pranlukast

[C] Prucalopride

[B] QTc-Prolonging Agents (Indeterminate Risk and Risk Modifying) Interacting Members Albuterol; Alfuzosin; Amantadine; Amisulpride; Amitriptyline; Amoxapine; Apomorphine; Arformoterol; ARIPiprazole; ARIPiprazole Lauroxil; Atazanavir; AtoMOXetine; Bortezomib; Bosutinib; Buserelin; Capecitabine; Chloral Hydrate; ClomiPRAMINE; Dabrafenib; Dasatinib; Degarelix; Desflurane; Desipramine; DiphenhydrAMINE (Systemic); Donepezil; Doxepin (Systemic); Doxepin (Topical); Ebastine; Eperisone; EriBULin; Ezogabine; Famotidine; Felbamate; Fingolimod; Fluconazole; Fluorouracil (Systemic); Formoterol; Foscarnet; Fosphenytoin; Gadofosveset; Galantamine; Halothane; Histrelin; HydrOXYzine; Ibandronate; Imipramine; Indacaterol; Indapamide; Isoflurane; Isoproterenol; Isradipine; Itraconazole; Ivabradine; Ketoconazole (Systemic); Lacidipine; Lapatinib; Levalbuterol; Levosimendan; Levosulpiride; Lithium; Loperamide; Maprotiline; Mefloquine; Methotrimeprazine; Metoclopramide; MetroNIDAZOLE (Systemic); Mianserin; Mirabegron; Mirtazapine; Moexipril; Nelfinavir; NiCARdipine; Norfloxacin; Nortriptyline; Octreotide; OLANZapine; Olodaterol; Oteracil; Oxaliplatin; Oxytocin; PARoxetine; Pasireotide; Pentamidine (Oral Inhalation); Periciazine; Posaconazole; Promethazine; Propofol; Protriptyline; Ranolazine; Rilpivirine; RisperiDONE; Ritonavir; RomiDEPsin; Salmeterol; Sertraline; Sevoflurane; Solifenacin; SORAfenib; Sulfamethoxazole; SUNItinib; Tacrolimus (Systemic); Tamoxifen; Tegafur; Terbutaline; Thiothixene; TiZANidine; Tolterodine; TraZODone; Treprostinil; Trifluridine and Tipiracil; Trimethoprim; Trimipramine; Triptorelin; Tropisetron; Vardenafil; Venlafaxine; Vilanterol; Voriconazole; Vorinostat

[C] Ranolazine

[D] Rifamycin Derivatives

[C] RifAXIMin

[B] Rivaroxaban

[X] Silodosin

[C] Siltuximab

[C] Simeprevir

[D] St. John's Wort

[B] Suvorexant

[C] Tocilizumab

[X] Topotecan

[D] Venetoclax

[X] VinCRIStine (Liposomal)

[X] Vitamin K antagonists: Acenocoumarol; Warfarin