Metformin and Recurrence Perfention

sas-schatzi · August 2016

May be something maybe not. But this has been on the TNBC thread for a few months. Hopefully the science GEEKS can add to this. I thought it was important to bring to the science forum. b/c someone seeking might not necessarily see it on the TNBC forum.

https://community.breastcancer.org/forum/72/topics/842776?page=1

I believe in it enough I started taking the drug. But you can see my words on the link.

Since we essentially, know nothing about the why's, unless proved by genetics, we have to seek every edge we can get.

I was asked for my BC profile recently. I took it off years ago b/c our stuff from "OMG They Found A Cure For Stupid" (first hundred pages) started to appear on f....b........ I wrote it that way so it couldn't be pulled by a query. What happened was I had to go look it up. Isn't that fun, I forgot all the bad stuff.

In my Path report were these words "unfavorable outcome". Well still kicking seven years(2009) and being a pain in the ass.

NO, NO. NO clue why I am still here, for those that follow, I write about Torodal, microbiome, NSAIDS. beta blockers.

Reason, something gives some of us and edge and others not. Science regretfully has clues, but NO clues for others. Any edge we can give ourselves-------------TAKE IT.

sas-schatzi · August 2016

Okay, must add I completely was devastated originally about the words "unfavorable outcome". I got by it b/c I had to deal with a dx of a brain tumor at the same time. Then a Dear Dear husband that was dx'd 3 months behind me with Lymphoma. The next few years were hell. BUT survived. Not that it's been easy. Other Chit happened.

But again no clue, of the why's grab what you can

Hopeful82014 · August 2016

Who knows the whys of it all? I do know I'm glad you're here, Sassy. Your posts on Toradol, etc., among other posts and support, really helped me.

Fallleaves · August 2016

Sas, I'm happy for you getting on the metformin. Everything I've read, too, has been very promising. I think the more ways we come at cancer, the less chance it has of winning.

wallycat · August 2016

Sas, what was your pathology?

sas-schatzi · August 2016

Hifolks, I was into the wine the other. Not the first time , nor the last time. Hadn't read the pathreport in years, I forgot some of the stuff. Two things set me off on a pity party.pT1c---which according to the material doesn't exist. But apparently does. The "ploidy" section had the value 1.79 (range 0 to 2.0) Unfavorable outcome. Grade 3(8), moved from grade2(6) from bx on Jan23rd to excision feb18th, no sampling error, as it was rechecked. That stupid phrase "Unfavorable outcome" was in two places.

Anywhooses, it shouldn't matter b/c I'm 7 years out. I have been hit with the insaneness of cancer in the last few months. Then that reread, really set me off. If it was so friggen unfavorable why am I still here. It's all such a crapshoot.

On the spectrum of the gals that have done everything right, to the supposed other end of the spectrum of everything wrong, I'm on the wrong end. My pity party wasn't just about me, I was feeling the loss of so many, and the pain that so many go through. Technically, I got it real good right now. I shouldn't be hijacking this space. Sorry, for that. Thanks for the encouragement and nice thoughts.

sas-schatzi · August 2016

Might as well add the serendipity part of the story. My twin had ER+ BC in 1996. One positive node. Mx followed by a second MX a year after chemo. Plus, I said we both had to get hyster and oophs out. Tamox was available, but I figured the science wasn't good enough yet. So out those oophs came.

Thought about a prophy for years. Talked for 3 years with PCP. The third year, 2008, I decided to do it. Strange internal push "Do it". But some very strange things happened. I was in Home Health at the time. Just before I saw the MO to start the process, at work one day I had a breast accident. My locking clipboard snapped shut on my left nipple and I jumped. Then the 4 inch ring binder fell on top of the clipboard. It sure was a YIKES moment.

MO used that injury to work on the prophy. Prohyies aren't that easy to get insurance approval. He lied about feeling a lump below the nipple and used my c/o nipple pain as the evidence to get things going. Mammo was in August---neg with the NED letter. Then in Sept, I had a total body fall at work. Hit everything except elbows. Then out of pure laziness, I didn't get the MRI done till Dec. That was the next step in the prophy plan. TaDa signet ring left breast @ 3 o'clock.position. BMX Feb 2009.

The final path report included cells up to the nipple. Was the injury a cause? Was it incidental? Why after 12 years did I decided a BMX had to be done? There are cases that have been reported related to trauma, most docs discount it though.

Then MO cooperated when I asked if I could have a brain MRI b/c of the work fall. I still had concussion type symptoms. TaDa brain tumor on the opposite side of the brain concussion side. Incidental finding. Meningioma. We watched it till it started growing and then took it out in 2012.

When I read stories of Docs diminishing patient concerns and putting off biopsies of lumps. My heart just cries. Too many here with such stories. Too many lost. I was lucky. Lucky? Luck shouldn't have anything to do with our lives.

Bulldozers shouldn't either, but that's what I'm feeling like that has hit me right now.

Anywhosses, I'm working on the depression. Medicine is coming. May work it out without it.

cp418 · August 2016

I just saw this article in reference to Metformin.

http://www.practiceupdate.com/news/13012/2/6?elsca...

Metformin Linked to Increased Risk of Acute Dialysis in T2DM

Metformin-associated one-year risk of acute dialysis increased by 50.3 per 100,000 individuals

sas-schatzi · August 2016

CP well chit...........it's a pay site to get at the full text. Something is fishy though. Metformins been atudied for a century and around as weed for use to control "sweet pee" for centuries. Plus, there was a decade long study on diabetes that found it safe and a first line drug.

See what else you can find. The disclosures said some of the researchers had pharmaceutical connections.

Guve it a try and see what you can find Thanks.

sas-schatzi · August 2016

A few seconds ago sas-schatzi wrote:

Folks I think John's link should be posted around in the threads you frequent.

1.Reason is most here have sleep problems.

2. It is a naturally occurring in the body

3. we need to use any thing that gives us an edge.

My personal experience with it is I used it for several years after BC @ the 10mg level along with Ativan. I had horrible insomnia. My ER+ path report said unfavorable outcome in two places. Always wondered why I haven't met'sd yet. Now 7 1/2 years.

I keep wondering if there was "something" I was doing that was helping?

Recent research is keying in on other things other than standard chemo drugs we need to keep these on our radar and make the decision whether they are reasonable to add to our regimen.

We all know it's still a crapshoot. I find that word the most disgusting word in the dictionary. So, this is an emphatic statement.

John reposting on my usual threads. Thanks for all the research you do.

18 hours ago JohnSmith wrote:

New article: Pre-clinical models reveal that Melatonin reduced proliferation of breast cancer stem cells in ER+ tumors.
https://blog.cirm.ca.gov/2016/08/24/sleep-inducing-hormone-puts-breast-cancer-cells-to-rest

TAGS: CSCs, transcription factor OCT4, encoded by the POU5F1 gene, mammospheres, Bisphenol A (BPA), MCF-7 cells

cp418 · August 2016

yes - the Melatonin news was posted in the Complementary Medicine Forum recently.

https://community.breastcancer.org/forum/79/topics...

Metformin and Recurrence Perfention

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Metformin Linked to Increased Risk of Acute Dialysis in T2DM

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