Neoadjuvant Chemo - Changing Drugs Midway

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MarkH111
MarkH111 Member Posts: 1
edited July 2016 in Chemotherapy - Before, During, and After

Hello,

My wife was diagnosed with triple negative, grade 3, node negative, 2.0 cm breast cancer 3 months ago. She was advised to do neoadjuvant chemo before surgery. She has gone through 3 rounds of TC, and today she had an ultrasound that showed no change in tumor size since diagnosis. ~ 2.0 cm still.

The doctors are now going to discuss changing her chemo drugs to see if she has a better response to something else. I believe AC + T was a possibility.

Needless to say, we were pretty disheartened that the tumor which should have responded well to chemo (grade 3, very high ki67) has not. I know the advantage of doing neoadjuvant treatment is that in cases like this they can switch drugs.

Has anyone switched chemo drugs in the middle of neoadjuvant treatment and had a better response? We are worried that we will still won't see any response with other treatments.

Thank You.

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  • Vildanbt
    Vildanbt Member Posts: 32
    edited July 2016

    Hello MarkH11

    My mother also switched treatments.

    She took 2 cycle docetaxel herceptin cyclophosphamide but the tumour size was same. After we switched two cycle 5FU adriamycin cyclophosphamide but still no response and they switched the surgery. After surgery She got cisplatin taxol herceptin 4 cycle and radiotherapy. We still go on with herceptin. Tumour has also high ki67 and grade 3

    Drug resistance is more common than we think. Most of people take it postoperatively so it is impossible to know sensitive or not. Luckily you do not have node disease


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