STUDY: EXERCISE AND ADVANCED BREAST CANCER
I had a wonderful phone conversation with Dr. Lee Jones of Memorial Sloan Kettering Cancer Center in New York City today. Dr. Jones is head of his own lab that investigates the impact of exercise on cancer (https://www.mskcc.org/research-areas/labs/lee-jones). He is beginning the first-of-its kind study on the impact of exercise on advanced breast cancer. He is currently conducting a Phase I trial to test the safety of his exercise prescription. He has a few more spots open, if anyone lives in NYC and is interested in this. The study requires participants to come to MSKCC three times a week for 12 weeks to undergo specific exercise regimes that vary from easy (about 50% of your cardio maximum) to hard (about 80% of your cardio maximum). He is soon going to be recruiting for a Phase II trial, which will extend outside of New York City. If anyone is interested in participating in these trials, I encourage you to contact Dr. Jones at jonesl3@mskcc.org.
Dr. Jones was delightful to speak with – he is very enthusiastic about his research, very knowledgeable and was very generous with his suggestions. The most important point that I took away was that it is important to vary the intensity and duration of your exercise. Like most people, I have a routine that I follow that I am comfortable with and rarely deviate from. He said that our bodies need variety in intensity and duration of exercise in order to reap the maximum benefits. Specifically, he said we should all strive to incorporate easy, moderate and hard workouts in our exercise routine, that this variation gives us the best benefit and potentially the best outcome for dealing with cancer.
How can exercise help cancer patients, you ask? Dr. Jones has been involved with studying the link between how well patients tolerate cancer treatment, whether patients who exercise have a better response to treatment, longer remissions, etc. He has conducted population studies, where he surveyed cancer patients about their exercise habits and compared their self-reports to their response to treatment, remission, etc., and found a connection between exercise and better outcomes. The work he is doing now allows him to precisely account for the amount and intensity of exercise that his subjects undertake. For the record: I have no financial or other connection to Dr. Jones, I just think this is very exciting work, and I told him I would be happy to participate in one of his Phase II studies if it came to South Florida.
Comments
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Scrunch, thanks for this post! I've exercised my whole life, and while it's often more challenging with stage iv, I feel better for it. This will be an interesting study.
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Thank you, Scrunch. I have heard theories that exercise helps people with MBC do better, but it has all been theoretical. It will be interesting to see the results of the trial. Do you know how long the trial will last? I assume that the final results will not be in until years from now since they will most likely follow participants for a long time.
Lynne
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Thanks, Scrunch! I would join the South FL study with you, if it ever makes it down here. When I was at a conference last year, Virgina Borges from U of CO was asked what is the one thing we can do to improve our immune system to better respond to metastatic breast cancer and she said exercise, hands down. I always keep that in the back of my mind.
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I love the doctor's prescription! Mixing intensity and duration sounds like a very good principle to follow. For one our bodies adapt to any exercise regime after which you are no longer getting the same benefits. Some deconditioning has to be built in with a minimum level of movement. Then reconditioning at a higher level. Just my 2 cents.
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Scrunch-thank you for posting this. It is exciting to see this kind of research taking place and I look forward to hearing more about the results. Meanwhile, I am encouraged to keep it moving:)
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Scrunch - great post, very exiting area of research in my opinion. I truly believe exercise is the one scientifically proven thing, within our control, we can do to help improve quality of life and overall survival.
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My onc just mentioned this trial at my last appt. and encouraged me to ramp up the exercise. Thanks for the additional details. I'd participate if location was convenient.
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I'm in the study with Dr. Jones at MSKCC. He is very impressive. Before, BC I worked out all the time and was VERY fit. Since my first surgery I have not had the energy/desire to work out, but I walk a lot when able to (depends upon my HFS) So, when my MO talked to me about the study, I jumped at the chance to join. There are 2 control groups. One that does 5 minutes of cardio followed by stretching-that's the one I was put into (it's random as to which group you get into) and the second group does about 40 minutes of cardio. I am happy just to be able to do anything to feel more like my old self.
Babs
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Sometimes when I feel terribly sick and tired, I know in my gut I need to walk ... and I do. I drag myself outside and get moving and I get my energy back.
Among the many many benefits, in the short term I believe that it clears and modulates all the byproduct of the drugs we are taking.
Thank you so much for this. It can be so hard to exercise. I need to see this kind of research.
>Z<
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Babs, good luck with the trial!
Zarovka, I've become addicted to researching on exercise and cancer. It really does help motivate one to move. It has kept me exercising daily for 7+ years now.
Exercise, future anticancer therapy?
https://www.sciencedaily.com/releases/2016/05/1605...
This one is in relation to prostate cancer. (An addict can't be picky.) There was also a recent one on cervical cancer risk reduction with just 30 minutes' exercise per week.
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When I first came to bco in 2012 I was paying attention to people who were here for a long time, or had remission for a long time, trying to find out how they did it. They all talked about exercising regularly.
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Hi Scrunch!
Thanks so much for sharing this research. My own personal experiment 6-7 years ago supports what Dr. Jones is learning about larger populations. In fact, I reset what oncologists in Seattle considered possible during treatment. A bit of cycling with hills fits the 50%-80% of capacity quite nicely. Anyway, I "sailed" through six dose dense of each AC + T, and kept my core fitness. I made it a point to do at least a mile of walking whether I felt like it or not. I cycled on weekends and did my weekday routine of weights and crunches.
I am fortunate to be cancer free now, and hope to keep it that way. I am still cycling as doing number TEN Seattle-to-Portland Bicycle Classic (200 miles over 2 days) this year. This keeps me training. I consider exercise part of my post-cancer treatment along with the daily aspirin.
Between then and now, I also took up running and normally fit in a couple of 5k runs a week. I am super-slow, but that isn't the point. It's to pound those bones, plus my route goes through a nature preserve, so I get to experience the woodland and bog.
I finished 5 years of anastrazole one year ago, and ended up with normal bone density scores.
Downsides of exercise? I wore out my bicycle recently and spent a fortunate getting it rebuilt. Likewise with other gear. But that is all part of the fun.
I will be fascinated to see what else Dr. Jones and others discover. Agree that exercise should be part of a comprehensive treatment plan.
And not just for survival. Because I also want to keep doing the things I love doing, not talk about the "things I used to do". - Claire
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I known that my mind needs me to keep walking. I try to go 2 to 3 miles a day. I have a mantra as I walk. Weight bearing exercise is good for the bones. I do keep my treatment team informed. I tell my RO he has to zap anything that gets in the way of walking. If my walking also helps to slow/stop growth of cancer awesome.
Mary
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Babs, my onc mentioned this trial to me and encouraged me to exercise more. I'm not in the trial due to location but wanted to take part on my own for what it's worth. I'd been looking for the details regarding the study groups so thanks for sharing. Couple questions: Is the exercise regimen daily? Are there any criteria as far as target heart rate goes? Not knowing, I've started running 3 times a week following the couch to 5k plan with slower progression as I had some pain with my knees. Try to keep the heart rate in the upper moderate to vigorous range. Actually liking it quite a bit so far. Love being outside and the weather's been great!
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Kaayborg
I go 3 times a week. I'm on the treadmill at 2.6 for 5 minutes and then do about 30-35 minutes of stretching exercises. I don't know what the desired target heart rate is but will ask tomorrow for you. Due to the Hand & Foot SEs of Xeloda I could never run. I used to walk home from work every day but now it's just too hard most days.
Babs
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Babs, thanks for the info. 3 days is very doable for me, 5-7 not so much. I also do 10-15 minutes of yoga near daily.
I am disappointed to hear about the hand, foot syndrome with Xeloda as that is one of my next treatment options and I had trouble with hand, foot when on Taxol (could only stand for 10 minutes with out burning, tingling, then painful itching...never had redness or peeling though which baffled oncs on what it really was) and it is not even a common side effect with T. That is a very uncool side effect I fear being easily susceptible to but then again, who knows? Everything's a bit unpredictable. Exercise does help feel I'm giving it my best shot for whatever it's worth. Very cool you can be part of the study.
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Check out Sunflower Wellness. There are numerous articles on the benefits of exercise for all cancers, especially breast. Lee Jones is on the Medical Advisory Board as are many other amazing doctors promoting the benefits. You can get a ton of information from the site and if you happen to be in the Bay Area, you can get a consultation for free. www.sunflowerwellness.org
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