Genetic Predisposition

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Momof6littles
Momof6littles Member Posts: 184
edited April 2016 in LCIS (Lobular Carcinoma In Situ)

I think this type of research is going to shed light on why those with LCIS have an increased risk for developing other cancers in either breast, as well as LCIS as a precursor tumor. I will post this in the ILC forum as well.

Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC399049...

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  • InStitches
    InStitches Member Posts: 80
    edited April 2016

    This is quite an interesting article on a complex topic

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  • Momof6littles
    Momof6littles Member Posts: 184
    edited April 2016

    The research into SNPs is getting interesting. My genetic counselor mentioned it. She said that if I test negative, since no one else has been tested, it is meaningless. And they suspect that those with family history and negative genetic test may actually have single nucleotide changes in several key genes that, on their own, don't confer an additional risk. But when working in concert, these small changes do increase your risk substantially. I think they are looking into a test for this.

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  • Claratmyft
    Claratmyft Member Posts: 2
    edited April 2016

    Hi,

    Okay. Unsure what to do. I am BRCA 2 positive and 53. A month ago by pure luck a small 1.5 mm invasive lobular ca was found in my left breast during an excisional biopsy for something else. However, extensive LCIS was also noted. I know of the bilateral issues. I'm from a medical family and married to a radiologist so I'm fortunate to be receiving good care.My problem is I don't want mastectomies. Yet, I'm being pushed by the breast surgeon, radiation onc and medical onc to do so. I have very dense breast and have been excellent with my servallience. I realize that LCIS is like looking for a black horse on a black night (very hard to see). But, they found and excised the tumor. I am cured for now. Why do I need this bilateral amputation?I'm having a hard time reconciling this. I have always had large breast and they are a part of my self image (for good or bad). I nursed 5 children with them and have grown very attached (as we all are). Just looking for some thoughts or experiences with this type of grey area decision. please excuse spelling errors, my iPod doesn't want to cooperate.

    Thank you,

    B

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  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited April 2016

    Clara, why don't you try asking your question on one of the ILC or BRCA threads? Women with LCIS only don't have the same risks you do. Your ILC and being BRCA positive "trump" your LCIS and I believe that is more why the doctors are suggesting BMX.

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