NEW TRIALS?

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4everStrong
4everStrong Member Posts: 118
edited April 2016 in Triple-Negative Breast Cancer

Hi there,

anyone informed about any new trial that we should keep an eye on. The ones I am reading about for TNBC treatments are as follows:

- Copper Depletion

- Immunotherapy

- Vaccine

anything else I am missing.. my onco doesnt talk about research much, so had to do my own reading.. I am not the best at internet search and would be interested by your own knowledge and findings.

please lets put our knowledge together and let others know about it.

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  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited April 2016

    If you use the "search" function here there are numerous threads on those topics, many with the research posted

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  • TulipsAndDaffodils
    TulipsAndDaffodils Member Posts: 80
    edited April 2016

    Hi 4EverStrong,

    I also think there are trials related to the androgen receptor. In addition to the 3 receptors that we all know they look for (estrogen, progesterone, and HER2), some triple negative tumors express an androgen receptor (I think I read maybe 20%). I think there are trials for those women who have androgen receptors to try some of the chemos used in prostrate cancer against their tumors. I think early results have been mildly promising, but they are enrolling people in trials with improved anti-androgen chemos, so these new trials may prove more helpful. My pathology didn't test for androgen, so I don't know if this is one for me or not. Since a lot of the trials and research are coming out of Memorial Sloan Kettering, I think they test ALL of the TNBC women for the androgen receptor there.

    I have my eye on the copper depletion, and the immunotherapy trials.

    I think there are trials for various stages: trials for people initially diagnosed with early stage TNBC (could be to add a parp inhibitor and/or carboplatin to AC-T neoadjuvant chemo, for example), for people who did neoadjuvant but had residual tumor at surgery time to reduce risk of recurrence, (now they are testing adjuvant xeloda and carboplatin for those ladies), and for people with metastatic TNBC. Which of those timings are you most interested in?

    I'd also love to hear which trials seem most exciting to people.

    Tulips

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  • 4everStrong
    4everStrong Member Posts: 118
    edited April 2016

    Oh thank you for all thé additional information.

    Now i am waiting to start off radiation might start taking metformin as i read that it could reduce reccurence.

    Will follow closely all the trials and hoping i could qualify for one of them.

    Keep sharing your thoughts.

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  • ruthbru
    ruthbru Member Posts: 57,235
    edited April 2016

    I was just scrolling around this afternoon & saw this topic. A triple negative friend of mine has been on the metformin trial for five years & just yesterday got a call from her clinic telling her to quit taking it (or the placebo, she doesn't know which she was on). They are wrapping up that arm of the trial (while continuing the hormone positive arm) because the research had shown no benefit for triple negative BC people. Just thought you'd want to know. Best wishes!

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  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited April 2016

    There's a site called Breast Cancer Trials.org (notification@bctrials.org) where you can enter your diagnosis and details and both search for and receive notice of new trials. Not all of those I've received have been relevant but it's a good site to know about nonetheless.

    There is an immunotherapy trial you might be interested in, the Herceptin/Neuvax E-75 trial, which is enrolling at a number of different sites around the country. It's for high risk ER+ as well as TN patients. If you're interested in it you would need to start the process now to see if you qualify for it, as the first treatment must take place no more than 12 weeks after your final standard of care treatment. I am enrolled in this trial and also know several TN woman who are part of it.

    http://www.cancerinsight.com/active/nct01570036/



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  • 4everStrong
    4everStrong Member Posts: 118
    edited April 2016

    Thank you all.. Will check the site. And also thank you for the metformin info.

    Additional info i received regarding vitamin D. So I am taking vitamin D. Aspirine and Blueberries every Day.



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  • ruthbru
    ruthbru Member Posts: 57,235
    edited April 2016

    Yes, Vitamin D is a big deal. Vitamin D is a big deal. It should be between 40-50 ng/dL. Many, many conditions are associated with low vitamin D; heart attack, cancers, rheumatoid arthritis, muscle weakness, asthma, diabetics, multiple sclerosis etc. etc. etc. There are over 200 different body tissues that have been identified so far that have receptors for the vitamin D hormone and they need it to work properly. Adequate Vitamin D levels has been shown to reduce the side effects of taxol based chemotherapy and has shown to reduce the side effects of aromatase inhibitors.

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