Has anyone heard anything about the MLN0128 trial?

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brandall
brandall Member Posts: 687
edited January 2018 in Stage IV/Metastatic Breast Cancer ONLY

I'm in the washout period right now, hoping to get on this trial. It is a phase 1b/2 trial looking at a parc 1/2 inhibitor paired with exemestane or fulvestrant. You had to have failed on either of those drugs to get on trial (I have failed both). Since they are still in the safety/efficacy stage, I'm a bit worried, but my trial oncologist has someone doing well on this combo almost 2 years out, so worth a shot.

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  • brandall
    brandall Member Posts: 687
    edited March 2016

    Well, I started this trial yesterday. Fingers crossed it is a winner. The drug is now also being called TAK-288. Yesterday I felt horribly nauseous, but I think it was a combination of fasting for hours (for blood work), faslodex shots, a kidney stone I'm trying to pass and the many vials of blood they took :) Today I still feel a bit off, but MUCH better than yesterday. I'll try to post here periodically with side effects/results. The University I go to seem to have a few people who are doing quite well, so I'm hopeful.

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  • Kandy
    Kandy Member Posts: 1,461
    edited March 2016

    I hope you do well on this trial. Please keep us informed. Best wishes to y

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  • ScienceGirl
    ScienceGirl Member Posts: 207
    edited March 2016

    Good Luck and keep us posted. Kidney stone - just awful, I've been there.

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  • Ohmydarlin
    Ohmydarlin Member Posts: 292
    edited March 2016

    Good luck on the trial!!

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2016

    Brandall -- Glad to see you post and that you were able to get on the trial! I hope the side effects will diminish and this will be a good regiment for you!

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  • Sarah1970
    Sarah1970 Member Posts: 5
    edited January 2018

    How did this turn out for you? I’m supposed to start it next week but don’t know if I’ll get the drug or just fulvestrant.

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