Blood vessel 'doorway' lets BC spread through blood stream

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cp418
cp418 Member Posts: 7,079
edited March 2016 in Clinical Trials, Research News, Podcasts, and Study Results

http://medicalxpress.com/news/2015-08-blood-vessel...

Blood vessel 'doorway' lets breast cancer cells spread through blood stream


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  • dltnhm
    dltnhm Member Posts: 873
    edited August 2015

    Very interesting findings.

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited March 2016

    News about this TMEM (tumor microenvironment of metastasis) research was released Fall 2014.
    Albert Einstein University in New York City has been researching this for a few years (here's a June 2014 PR called: "New Test Predicts If Breast Cancer Will Spread").
    I also wrote about it here. It looks like this latest research further elucidates the mechanics of TMEM.

    A tiny company called Metastat in Boston Massachusetts has been trying to commercialize a diagnostic test (was called 'MetaSite Breast', now called 'MenaCalc') to exploit this research. Essentially, they are developing an assay that determines the likelihood of metastasis. Initially, it was geared towards ER+, HER2- early stage breast cancer patients, but now appears to cover all early stage disease.

    They are taking a very different approach compared to the common gene signature tests such as Oncotype, MammaPrint, and Prosigna.

    It's certainly interesting, but probably needs to be validated with clinical trials, so perhaps years from being clinically available.

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited March 2016

    I'm not sure how I missed this news from last month. It's from the Blog of Dr. Francis Collins, the Director of the NIH.
    It's a video that explains how breast cancer cells leave the primary tumor to metastasize through a doorway in the blood vessel.
    This deals with the original link cp418 posted last August.
    "Cancer Cell Invasion"

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  • Heidihill
    Heidihill Member Posts: 5,476
    edited March 2016

    Great video! More details than another video previously linked in this forum.

    http://news.mit.edu/2016/cancer-cells-remodel-envi...

    A protein called Mena-Inv seems to be the culprit.


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  • Sunnyone22
    Sunnyone22 Member Posts: 191
    edited March 2016

    I just watched the video about blood vessel 'doorways'. Unbelievable! This insidious invader actually acts in a targeted, evil way! Fascinating and downright fearful. When I look at the one-size-fits-all systemic treatments being offered to us to prevent metastasis, I realize how we're shooting a garden hose at a terrorist.

    John, thank you so much for this link and for all the links you provide. Those of us with ILC's have a unique opportunity to educate MO's. Remember, MO's handle many, many different types of cancers in many organs. No doubt we spend more time reading up on ILC than they do.

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