Irisin destroys aggressive cancer cells

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dlb823
dlb823 Member Posts: 9,430
edited March 2016 in Clinical Trials, Research News, Podcasts, and Study Results

A friend just shared this elsewhere, and I thought I would repost it here. Not sure how much exercise is needed, but walking 5 to 6 miles several times a week (as I did for several years following my initial dx and tx) and actively going to the gym certainly wasn't enough in view of whatever was going on in my body. Still, it's an interesting study and one that will motivate me to overcome my fatigue and get more exercise.

http://m.medicalxpress.com/news/2015-02-irisin-agg...


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  • wallycat
    wallycat Member Posts: 3,227
    edited February 2016

    I'm with you.... clearly my 2-1/2 hours a day pre-cancer did not work.


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  • Heidihill
    Heidihill Member Posts: 5,476
    edited March 2016

    Maybe too much irisin could backfire? Maybe some folks don't produce irisin? My own theory for exercise-resistant cancer is that estrogen trumps all for some of us. The less estrogen, the more exercise works. Sort of like bisphosphonates (bone strengthening drugs): Anti-cancer effects are seen in a low-estrogen environment, that is, for postmenopausal women.

    One other factor behind the benefit of exercise is adrenaline and how this guides natural killer cells to target tumors. Also exercise increases natural killer cells in the body, so you get a double whammy.

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  • dlb823
    dlb823 Member Posts: 9,430
    edited March 2016

    Interesting thoughts, Heidihill. Our bodies are just so complex -- and to some degree unique -- it's very difficult to isolate one hormone process, for example, and think it will always hold true when other hormones or other factors can be so individual.

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  • Fallleaves
    Fallleaves Member Posts: 806
    edited March 2016

    I wonder if there is a "sweet" spot with exercise? I know strenuous exercise can actually be immunosuppressive, but I think that mainly applies to endurance athletes like marathon runners. But for moderate exercise I think exercise stimulates the immune system. Maybe it makes it more responsive to inflammation, so you don't have the chronic inflammation that promotes cancer growth. Also, exercise mildly reduces sex hormones in the blood stream, and significantly increases sex hormone binding globulin (SHBG) which traps those circulating hormones, and may lead to weight loss which more strongly reduces hormones and increases SHBG.

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  • new_direction
    new_direction Member Posts: 449
    edited March 2016

    thanks for this interesting news.


    I just did some searching and found something worth considering:

    http://www.sciencedirect.com/science/article/pii/S...

    Notably, the serum irisin level had a greater correlation to the level of circulating DHM than to the amount of exercise.


    Not suggesting to skip exercise, but maybe a combination is even better :)

    http://www.amazon.com/Dihydromyricetin-Scientifically-Hangovers-Naturally-Obtained/dp/B00CX60CMA

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