30% develop metastatic cancer?

windingshores
windingshores Member Posts: 704
edited February 2016 in Stage I Breast Cancer

I don't know where to post this.  I just read an article about a new push to raise the percentage of breast cancer research from 7% to 30%  for metastasis, to match the 30% of breast cancer patients whose cancer spreads.  I have never seen the 30% figure and it doesn't match the numbers I have seen for our risks according to Oncotype, cancermath, etc. and MD consults.

As I write this, "Metastatic trial search" and logo can be seen above, right here on the forum.

I understand the difference between risk of recurrence and risk of spread, of disease free survival and overall mortality and so on. How have I missed the fact that 30% of us will have Stage 4?


Comments

  • DivineMrsM
    DivineMrsM Member Posts: 9,620
    edited February 2016

    cp, thanks for providing that the link to that thread; it's one I've contributed to.

    winding, it certainly doesn't mean that 30% of women with stage i bc progress to mbc. The percentages are spread out. Off hand, I don't know the specific breakdowns, tho you may find it on the linked thread if they are even available. But how I think it works out is a smaller percentage of stage i patients will progress, stage two percentages of progression to mets would be higher and most likely, women diagnosed with stage three bc would have the highest percentage of progression to mbc. (This is where I think the "early detection saves lives" slogan comes from). So the 30% is spread out across the stages. I've read that the figure may be 28%. Hope this helps your understanding of the statistic and even tho that other thread on this subject is long, you should be able to browse through the posts for more insight.

    This is only an example, there is no scientific backing of this, but to show my train of thought it might look something like this: stage i: 5% progress to mets, stage 2: 10% progress to mets, stage 3: 15% progress to mets, the percentages add up to 30%.

  • Scwilly
    Scwilly Member Posts: 489
    edited February 2016

    Thanks Mrs M (I love all your posts btw) - I checked out the link - and it does show how confusing stats can be and how headlines can be misleading.

    Sorry to butt in but stats are my thing (I'm hopeless at spelling etc) You usually can't add up percentages - you can average them if the cohorts (group sizes ) are the same. If (and only if) there were 100 people in each of the three groups. That would be 5+10+15 = 30 people out of 300 people which is 10% i.e. the average.

    The quote below from MsBrompton in that link is a great example of how confusing numbers/percentages can be.

    As someone in this thread has already said, "28% of women with stage IV BC started with stage 0. I, II or III" is NOT the same as "28% of women with stage 0, I, II or III will get stage IV".

    Say there are 100 women with BC, and say 10 of those women eventually get stage IV. Of those 10 women, 3 were diagnosed with stage 0, I, II or III while 7 had stage IV at diagnosis. But 90 women never go beyond the other stages! I made those figures up, but I hope they illustrate the fallacy being perpetrated."

    Theres a great program called More or Less on the BBC which looks at numbers in the news and clarifies and/or debunks many of the media headlines.

    I am always looking out for stats which will give me hope that I have a great chance of getting though this awful disease. I do find myself being biased to those that I feel are more positive and flipping past those with more dire chances. The best thing I find for me it to stop thinking of the stats of reoccurrence and to let time time take its course. I'm 2 and a bit years out from dx and waiting for that magic 5 years promise for triple negative BC. Though I must remember even this is not a guarantee - just a statistic!

    Sarah

  • Lolis197138
    Lolis197138 Member Posts: 512
    edited February 2016

    windingshores, I remember reading that 1 out 3 women diagnosed with stage 3 will progress to stage IV. As the other ladies mentioned stage I & II will have lower percentages.

    When my BS ran my numbers on adjuvant online after surgery it came with 72% change of survival so the risk/change of progression is 28%, still high in my books.

    I like looking at stats and I as I approach my 2 years anniversary I am happy to be here but I know that my type of BC can show up years and years later but I am happy of these milestones.

  • Meow13
    Meow13 Member Posts: 4,859
    edited February 2016

    According to my oncodx number with hormone therapy I have a 23% chance of distant recurrence.

  • DivineMrsM
    DivineMrsM Member Posts: 9,620
    edited February 2016

    ScWilly, thanks for your explanation. I know there are people who love and study stats, I read your post several times for comprehension until it made sense. Like you, I also look for ones with a positive slant in my favor!

    Statistics are useful in many ways. It's not something I concentrate heavily on, tho I am aware of them. It does make sense to me that more research funding should be funneled into metastatic bc, since the statistics show how it recurs. Statistics show that there isn't yet a cure for bc, tho the early detection slogans surrounding bc fundraising might have the general public believing there is. Once diagnosed, even if treated and no trace of cancer is found, I think many women have that feeling that it might come back one day.

    In my case, being diagnosed stage iv from the start, I am currently on the better end of the statistics for longevity, now 5+ years dealing with it. The stat is something like 80% of women live less than four years after being diagnosed metastatic. Being stable on Arimidex for over 3 years classifies me as an "exceptional responder" and livng six years past the diagnosis, one is considered an "outlier". I said that's my New Years resolution, to become an outlier.

  • windingshores
    windingshores Member Posts: 704
    edited February 2016

    Thanks all. I was quoting from the media, yes, and I posted not so much out of anxiety but because I suspected there was something wrong with the headline :)    I appreciate the clarifications. And The Divine Mrs M here's to your being an outlier.

  • Supportive
    Supportive Member Posts: 81
    edited February 2016

    Just wanted to add overall stats can be misleading until you break them down. So 1 in 8 is the odd over the lifetime of a woman who lives to 80 yrs old. The % increases the older she gets and that is why

    1 in 8 women will have bc. But it is broken down into 20 to 30 yr olds have a 1 in 1800 chance and 30 to 40 have a 1 in .... etc etc.

  • Penzance
    Penzance Member Posts: 101
    edited February 2016

    HI

    If you're looking to get stats on your side, S J Gould's 'The median is not the message' is a great read.

    Best wishes.

  • windingshores
    windingshores Member Posts: 704
    edited February 2016


    The media needs to be more careful: this article title was not only misleading, but wrong. Though I am sure it drew readers in, which is unfortunately often the motivation in writing article headings.

    Speaking of titles, "The Median is not the Message" is a clever one.




  • Lj061197
    Lj061197 Member Posts: 47
    edited February 2016

    The media always seems to making stories worse than they are. When I read the headline it scared the he'll out of me, even though my oncologist said I have a reoccurring rate of 4%. They really need to think about people's reaction before theynprint.

  • Leslie13
    Leslie13 Member Posts: 202
    edited February 2016

    That stat is over 20 years or more. It's much lower for the first 5-10 years. And most breast cancer still happens to older women, so could have died from other causes. I'm almost 60 and my family's lifespan is in the early 80s. It's only been the last few decades where people live to their 90's, but often with a lousy quality of life.

    We need to remember to live in the "now" because we don't know when our numbers up

  • Meow13
    Meow13 Member Posts: 4,859
    edited February 2016

    In my family health starts going downhill at 80.

  • dlb823
    dlb823 Member Posts: 9,430
    edited February 2016

    I haven't read all the above comments, but I can add that when I first saw the 30% stat I asked my UCLA onc about it and she explained that approximately 30% is a very broad average. Stage I recurrence stats are much lower than Stage II, and Stage III will be higher. So if you are Stage I, your overall recurrence risk is considerably lower than 30% -- maybe more like 5 or 10% -- not sure exactly, but you get the idea. Then, even within those stages, there are variances based on hormonal stats, Her2 status and possibly other things. So it's not 30% across the board, but considerably lower or possibly higher depending on your individual stats. Deanna

  • Bobcat86
    Bobcat86 Member Posts: 29
    edited February 2016

    Currently only 3% of the money goes to metastatic breast cancer.  I believe that 70% should go to  metastatic breast cancer.  What is everyone's worst fear ? metastasis! We need a true cure.  Over 40,000 die per year in the U.S. How many more mother, grandmothers, daughter, cousins, neighbors, friends, coworkers .... Must we lose. Yes education is important but the numbers of deaths have not declined and younger and younger women are being diagnosed. All stages should stand together to fight for the money to go into research for metastatic breast cancer which is everyone's true fear. We have been pouring money into Breast cancer for over 50 yrs where are we now fifty yrs later we are still dying. It is rare I believe less than 6% is stage 4 from initial diagnosis the rest were diagnosed with early stage and celebrated being cured at the five year mark why don't they post a 10yr chart? How well are we doing in 10years what are the numbers .  I don't mean to frighten anyone but I want women to unite no matter what stage Breast cancer stand up and fight for more money for metastatic breast cancer a cure for all of us. A cure for the fear everyone who has had or has Breast cancer the progression to a metastatic state .

  • Traveltext
    Traveltext Member Posts: 2,089
    edited February 2016

    For those interested in the truth behind all the funds wasted on BC awareness in October, check out the site that the Pinktober Revolution thread gang on BCO have put online: www.pinktobersucks.com.



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