Help me interpret this

Wait, the report said something else.

"TP53 is a tumor suppressor gene. Germline variants of TP53 have been associated with Li Fraumeni syndrome. Somatic TP53 variants are frequently seem in different malignancies."

So it doesn't differentiate???

I did a search of TP53 on this site and I found this in a different post.

"t is important to keep in mind that a mutation is the p53 gene is not considered to be inherited like the BRCA gene (in other words, it isn't what we call an inherited mutation, but instead a somatic mutation) p53 genes will mutate over our lifetime due to environmental stressors. So we probably all have a mutated p53 gene in the cells that turned into breast cancer.

Testing for that mutation does not mean your children may have it. It means we smoked, got exposed to carcinogens, ate too much junk food, hung out in a large city with smog, etc. That's why looking for the antibodies to a mutant p53 protein isn't that informative. Where my company is doing the research is looking at it as a cancer screen. It is mutated in so many cancers.

Does that make sense? I can try to explain it better, but please don't think it is a test like BRCA 1 and 2, because it is definitely not. In other words, you have a mutation because of what you have done, where you have been, how you have lived. If your child is living differently, they likely won't get the mutation. This is why it isn't useful in genetic testing for a predisposition to BC or ovarian cancer like BRCA, but why it is a good screen for an existing cancer."

So does that mean if I don't have the genetic version that I did this to myself? Effed upso badly it was more likely to be treatment resistant? How did I do so much damage in only 28 years on this earth? I'm an athlete, never smoked, never did drugs, never drank heavily, maintain a sub 25 BMI for all but one year. But 1) I really like chocolate 2) the summer I was 20 I worked 12 hour days and didn't know how to cook so I ate fast food every day, I didn't think it would do me any harm because I was thin and had an active job 3) I didn't know anything about bpa and used to heat stuff in cheap plastic all the time and drank out of plastic water bottles.

Ugh this sucks. Either I have a mutation that will dispose my family members to scary, early onset cancers or I have a mutation that makes me resistant to treatment (which surprises me because I did neo chemo and had an incomplete but still strong response - cleaned out a bunch of my lymph nodes and shrank the tumor hugely).

Alright, I found out something else interesting.

TP53 also seems to be related to CHEK2 mutation. CHEK2 is also related to colon and prostate cancers, which have been present in my family.

So there seems to be three possibilities with the TP53 mutation.

1) I have it but there's no link to hereditary cancer - kinda weird since I had a good response to neo chemo.

2) I have it and Li Fraumeni.

3) I have it and CHEK2.

Of course there's Door #4 - I have a germline mutation that hasn't been identified yet.

I really need to speak to a genetic counselor