Ki67 and Oncotype

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2015

    Hi SummerAngel, just saw your post.  We have a similar diagnosis.  I had isolated tumor cells and Oncotype of 11 with a 2.2cm IDC.  No chemo.  BTW, we come to Colorado every summer to hike.  Good luck to you.

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  • AnniebNJ
    AnniebNJ Member Posts: 33
    edited July 2015

    ki67 was 30%, oncotype 19. Highly hormone receptor positive for both er and pr.

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  • Englishmummy
    Englishmummy Member Posts: 337
    edited July 2015


    My onco dx was 11 and my ki67 was 6% ....99% ER+ & 85% Pr+

    Hello, SummerAngel: I am in Colorado Springs and also have Bi-lateral BC

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  • plumster1
    plumster1 Member Posts: 270
    edited August 2015
    Really interesting topic.. My ki67 was 5% waiting on my oncotype dx result...so I will see
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  • 614
    614 Member Posts: 851
    edited August 2015

    My Ki67 was 21% and my oncotype score was 14.

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  • tshire
    tshire Member Posts: 239
    edited August 2015

    My Ki67 was 34%, my Oncotype was 20.

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  • shelleym1
    shelleym1 Member Posts: 298
    edited August 2015

    so glad I came across this thread because I have been baffled by my own results. My ki 67 was 26%, my oncotype 15. This shocked me since my mitotic grade was only a 1! I did not expect to see such a high ki67. I was advised not to do chemo despite the ki67 and my age. I also had LVI present. I was highly ER/PR positive. She said Oncotype was most the important factor. I hope they're right.

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  • teacher30plus
    teacher30plus Member Posts: 13
    edited December 2015

    Very interesting info. My core biopsy pathology report ki-67 was an alarming 94%. RO pretty much dismissed it and said, that it was a mistake. BS says that it could be because both my PR+ and ER+ were 95 and 100. I am anxious to know what the oncotype will be when I have surgery on the 4th. I will update after final pathology.

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  • farmerlucy
    farmerlucy Member Posts: 3,985
    edited December 2015

    teacher - good luck with surgery. You got this. My onc pretty much dismissed the Ki-67 too. Wishing you nothing but good path reports.

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  • Girl53
    Girl53 Member Posts: 225
    edited December 2015

    Am also wondering as I await Oncotype results...my tumor was quite small, low-grade, negative for LVI. But PR negative. Is it possible that this one factor could push my score up into intermediate risk level? Yikes. Keep trying to find info on this. Have read that PR neg status is more of a problem when it accompanies Her2+ status than when it doesn't, but not sure.

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  • Warrior_Woman
    Warrior_Woman Member Posts: 1,274
    edited December 2015

    My BS at Penn doesn't test ki67 but my local hospital does. My local MO said they are going to stop testing ki67. I am having a difficult time as I repeatedly find articles claiming the validity of ki67 with concern over different standards of measure. I'd love to find an article that claims ki67 has nothing at all to do with recurrence. I am just not getting why the literature claims one thing and they're doing something different.

    teacher & girl - I sending positive vibes with hope for low oncotype scores for you both.

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  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited December 2015

    My original Ki-67 was 43% and Oncotype (using same biopsy sample) was 20.

    After neoadjuvant letrozole the Ki-67 dropped to 4% in the tumor and 1% in the node, which probably would have resulted in a lower Oncotype but that's not the protocol for Oncotype sampling.

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  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited December 2015

    Warrior Woman, there's a lot of debate about Ki-67; it seems to go institution by institution. One researcher told me that if the same lab is used for reading each of your biopsies, the Ki-67 will be fairly reliable. If you had a biopsy read in one path lab and another elsewhere there might be more valid concerns about variability/unreliability.

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  • Warrior_Woman
    Warrior_Woman Member Posts: 1,274
    edited December 2015

    Hi Hopeful - My ki67 was 40% an my oncotype was 24. Our numbers are similar in that aspect. There was reasonable consistency with the labs in all other areas of the pathology. As I did chemo after my BMX, I'll never really know the effectiveness of the chemo. I'm really glad to hear your numbers dropped as much as they did. I did read a report that ki67 prior to chemo means nothing and the post chemo numbers are what matters more. I think that is good news.

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  • Mama3M
    Mama3M Member Posts: 23
    edited February 2016

    Hello!!

    I need to know if anyone has ki67 around 30%..and took cyclophosphamide+ docetaxel ...what are the side effects to be expected...and what it is the total number of cycles expected

    Thank you


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  • doxie
    doxie Member Posts: 1,455
    edited February 2016

    My Ki67 was 40%. I had 4 X TC. Do you have information on your Oncotype DX?

    My symptoms from chemo were the usual. Lost my hair two weeks in, felt like I had the flu for a few days after each infusion and taste buds didn't function. After the last infusion I had very low Red blood cell count, so was exceedingly exhausted until that improved. I opted out of a blood infusion because chemo was done. I also had an allergic reaction to Neulasta, but that is unusual.

    I worked throughout treatment and took days off as necessary.

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  • Kiks1
    Kiks1 Member Posts: 254
    edited February 2016

    My ki67 was 8%, mitotic rate 1, grade 2,oncotype 28. But I also am er+ 81%, pr- 1%, and her2-. I believe the low progesterone tends to push oncotype scores higher. I am doing 4XTC. Just finished first infusion so can't tell you much about SEs.

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  • tshire
    tshire Member Posts: 239
    edited February 2016

    Hi Mama3M,

    I am very similar to you- my Ki67 was 34%, ER+ 98% PR+ 83% HER2-. Oncotype 20. I also did 4x TC. I really did not find it to be that bad. To me it was very similar to having a hangover for about 4 days after each cycle. I did cold caps and kept almost all of my hair. I never had bad blood work so I never needed Neulasta or a blood transfusion. I had some dry mouth, a bit of fatigue, a touch of nausea, diarrhea/constipation, and the rest of my body hair did fall out eventually. But it was not horrible, and I worked through chemo, only taking 3 days off after each cycle.

    I wrote a list of tips- search for Tiffany's Twenty Terrific Tips for Chemo and you'll find it.

    Good luck!

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  • Mama3M
    Mama3M Member Posts: 23
    edited February 2016

    I'm waiting for oncotype score...does anyone have low score despite of high ki67 %

    Thank you for your support

    Special thanks to Tiffany for the amazing tips...

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  • farmerlucy
    farmerlucy Member Posts: 3,985
    edited February 2016

    yep! Me! 22% ki67

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  • windingshores
    windingshores Member Posts: 704
    edited February 2016

    My ki67 was 20 %, grade 3, LVI but Oncotype 8. 

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  • shorty123
    shorty123 Member Posts: 14
    edited February 2016

    er positive 100%,pr positive 60%, mitotic score 1, ki67 2% and OncotypeDx score 10.

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  • Mabs
    Mabs Member Posts: 36
    edited February 2016

    Mama, I had ki67 25% and oncotype 11.

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  • Mama3M
    Mama3M Member Posts: 23
    edited February 2016

    Please I have one more question...as I'm in the treatment decision stage...

    anyone is arround 56 year old as me was on docetaxel + cytoxan ?? Was it tolerable ?? I also already have heart problems.

    Thank you


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  • doxie
    doxie Member Posts: 1,455
    edited February 2016

    Mama3M,

    I was your age when treated with 4 X TC. I worked throughout all treatment. Not easy, but I managed. I posted more above.

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  • Mama3M
    Mama3M Member Posts: 23
    edited February 2016

    Anyone had FEC (5-fluorouracil, epirubicin, cyclophosphamide) six cycles.....please can you share your experience as I was prescribed this one.

    Thank you

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  • ShetlandPony
    ShetlandPony Member Posts: 4,924
    edited February 2016

    Hello, Mama3M. I'm afraid you are not getting a lot of responses because this thread topic is not about FEC. Here is a way to find posts about FEC. 1. Click on the blue Search on the side bar. 2. Type FEC in the box that says keyword then click on the red Search button. 3. Scroll to the bottom and click on Relevancy. 4. Click on any of the FEC results. Some of these may not be active, but still have useful information.

    Also here is a link to the Starting Chemo February 2016? topic.
    https://community.breastcancer.org/forum/69/topics...


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  • JuniperCat
    JuniperCat Member Posts: 658
    edited March 2016

    Hi! I'm curious, do most BS or MO request a Ki67 test? I am sure that my tumor wasn't tested for this. Should I ask for it to be tested? Thanks!!

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  • doxie
    doxie Member Posts: 1,455
    edited February 2016

    Some do and some don't. Part of the problem is that the methodology for the test is not standardized. Also, Ki67 measures cellular activity. It could indicate aggressive cancer or cell repair after a biopsy. I had an excissional biopsy, so felt my Ki67 was accurate. This was backed up with my overall Oncotype score.

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  • Carlymel
    Carlymel Member Posts: 8
    edited February 2016

    My ki67 was very low (2 or 3) so my oncologist told me that me Oncotype DX score would likely be in the low risk range. It was a 26 (high intermediate). I had four cycles of taxotere and cytoxan. I completed the last cycle on February 1, 2015. I was petrified of chemotherapy. It turned out not to be that bad. I did have some side effects, but they generally only lasted 3-4 days. The worst part was losing my hair. I do have a beautiful wig which I'll wear until my hair grows back. Good luck to everybody! It feels great to be a survivor!

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