Wow--had no idea that weed itself is estrogenic. I have a different quandary, though. The IL MM app has a bazillion disclaimers on it--including that the patient must acknowledge that MM possession is a Federal felony and that (s)he holds the State of IL harmless in case of arrest by Feds (or erroneous arrest by IL police not familiar with MM statutes). And by acknowledging that I know MM is still illegal under Fed. law, I may be setting myself up for disbarment (though I’m retired, I still keep my law license active) and ineligibility for a Global Entry air travel card because I am declaring my intention to (and would soon and inevitably) commit a Federal felony!!!!!

Has anyone here suffered any adverse legal consequences as a result of holding a duly-issued MM card and using MM? “Law Clerk Google” seems silent on the issue.

A lot of people say marijuana is dangerous for ER+ breast cancer (specifically the THC) because it is estrogenic, but there is actually evidence that the opposite is true.

Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ).

Show full citation

Abstract

Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) has been reported as possessing antiestrogenic activity, although the mechanisms underlying these effects are poorly delineated. In this study, we used the estrogen receptor α (ERα)-positive human breast cancer cell line, MCF-7, as an experimental model and showed that Δ(9)-THC exposures markedly suppresses 17β-estradiol (E2)- induced MCF-7 cell proliferation. We demonstrate that these effects result from Δ(9)-THC's ability to inhibit E2-liganded ERα activation. Mechanistically, the data obtained from biochemical analyses revealed that (i) Δ(9)-THC up-regulates ERβ, a repressor of ERα, inhibiting the expression of E2/ERα-regulated genes that promote cell growth and that (ii) Δ(9)-THC induction of ERβ modulates E2/ERα signaling in the absence of direct interaction with the E2 ligand binding site. Therefore, the data presented support the concept that Δ(9)-THC's antiestrogenic activities are mediated by the ERβ disruption of E2/ERα signaling.

Deanna, that cartoon....so funny, and so true at the same time!

http://www.pbs.org/wgbh/pages/frontline/shows/dope/body/effects.html

Honestly, I don't know if THC produces helpful or harmful effects on Estrogen. It's easy to find research for either argument. Man boobs i always thought, were an obvious reason to believe it was Estrogenic. So are many things in our diet.

Bottom line is I don't want to be high or have inhalation damage. I have small amounts of lung damage, likely from being a heavy user when young. So I want a high CBD/THC ratio. We all have to do our own research and do what is comfortable.

BTW, my sis brought me a CBD candy bar, and I tried some Monday. Worst pain day since last surgery. Was it the candy or major overactivity the day before? I don't know. I've tried bud a few times over the last 5 years, and it knocked me out and amplified my pain. It could just be me, like people with paradoxical pain med reactions. I'll try CBD's again, just to test results.

I always say we each have to make our decisions on our unique circumstances. There's research that supports any viewpoint you take.

Hi Ladies

well after reading and reading about CBD oil, I bought some today. Apparently, yes, you can buy it legally here in PA. The girl at the store told me to just drop a few drops under the tongue. Sort of a little edgy to use it as I am doing chemo. Anyone else on chemo that is taking it.?

Wendy is that how you take you CBD? Under the tongue?

Thanks

Rosieo

Since I live in OR, and more than qualify (as we all do) for med mj card, I might as well come out of the closet. After much independent researching, I came to the conclusion that using high CBD/low THC mj may really help.

My local cannibis atore directed me towards a strain called "Frank's Gift" a strain developed by a grower for his friend with cancer.

I can only buy leaf legally w/o an MJ card. So I purchased $10 worth. Did smoke it in small amounts. It barely had a high. Plesant buzz is more like it. And it helped me with pain. The CBD's in this pot are about 17% and THC 5%.

It's 4 days and I still have some left. I just had my Hip Replacement cancelled, from Cellulitis in my ear. I thought 3 months after my first surgery was too soon. I got it b/f trying mj. But I'm coping with a fair amount of pain with bad hip and other problems, so anything that helps is good.

As I always say: I did my research and made my choice. Everyone has to make their own choices.

And Wendy, I'm waiting for your results with bated breath. I'm really hoping you're on to something. Also that the cancer is going away and giving you more time.

Thank you Deanna, you always find the best links

Well count me as very interested. I plan to follow along here and when I find the time I may start the process of obtaining a card. I have a couple of friends who use MM and seem very informed who can probably help as well. I am along the same lines as Deanna where I am open to the idea but will bide my time until it seems to be the thing to do for me. Good research on everyone's part! I learned a lot as usual. Wendy, I hope your results are profound!

I didn't want to see this topic die, as medical MJ can be very helpful for some people.

I'm excited because I met with a new Pain Management provider and he asked me about using MM before I brought it up. I'm keeping this Dr! The trick is getting a high enough dose of CBDs, which is impossible by smoking. He recommended oil or capsules. I even get a bonus - his brother is a gynecology oncologist, which means he deals with a lot of breast cancer and is into alternative treatments. He's arranging a consult for me.

I plan to ask many questions about MM and other treatment's he's found successful. This is great news for me, as I've had a very sucky 2 months with medical providers, and honestly have been fighting to receive the right care all along. I'll share what I find out, and do more searching for research studies, so we know what's been shown to work. I hope there's more of you who want to join in and let others know what you find.

It would be nice to have Wendy with us, but she didn't receive the results she wanted and maybe doesn't want to talk about it. Hopefully she's getting the support and care she needs I don't know what or how she was using MJ; my Dr just said it's impossible to get enough through smoking, and you must use highly concentrated CBD with lower THC at a 4:1 ratio, or perhaps lower on the THC if that much is incompacitating. I still can't believe a mainstream provider told me I should be using MJ. This has been a good day!

Leslie and Wendy

I will hope that this thread does not die. I will certainly post. I have no experience with marijuana, but I have done a lot of reading and even, just last week, bought some CBD oil. The person at the store where I bought it said that the way to use it is to put a dropper under the tongue.

I have not used it yet. Still not sure. Wish more Dr's would give us some advise. I am taking chemo so my main question is "Would it be alright to take it as suggested while taking chemo" Very glad to see this thread. Would like to know more and will certainly keep up with whatever you can bring us.

Thanks Rosieo

I plan to follow this thread as well and explore the subject in depth. It just seems logical to me that cannabis in all forms can help with many medical maladies. I don't think it would have made it this far if that were not true. I just need way more information and validation of benefits. If I find a reputable dispensary and some science based evidence supports it's use I will be the first in line to try it. Starting with trying it to ease anxiety and better yet stunting tumor growth. I was speaking with a co-worker today who was very embarrassed to admit that her recently graduated daughter, in physical therapy, was volunteering at a dispensary and totally advocates alternative medicines including MM. I told her that this is a movement that is gaining huge momentum and her daughter should be applauded for following her heart.

News from Australia:

Historic medicinal cannabis legislation passes Parliament

Parliament has passed the Australian Government's historic legislation delivering the "missing piece" for Australian patients and their doctors to access a safe, legal and reliable supply of medicinal cannabis products for the management of painful and chronic conditions.

24 February 2016

Chi, that is definitely something I should think about as well since I work with children in a state entity. Thanks Stephanie, Good for Australia!

https://scholar.google.com/scholar?start=10&q=cannabis+breast+cancer&hl=en&as_sdt=0,38&as_vis=1

Wendy, don't u think a vacation to Oregon may be just what you need?

Here's a link to many research studies. I'll keep looking for more details about what we need to take, how to use MM, and amounts. Most of what I'm finding are studies saying MJ works, but don't translate into how much to use. I'll keep looking