Tamoxifen vacations/do side effects abate?

Mine were definitely related to brand. Had little side effects on Mylan but Watson was a different story - fatigue, cognitive issues, mood, etc. hated it. I got back on Mylan for awhile until CVS couldn't get it and ended with another brand I can't remember. I just finished 2 and 1/2 years. The last couple of months were tough. I took a break before moving to Anastrazole and it was great. For the past year I have also been taking Palbociclib and I think that might have made the Tamoxifen symptoms worse.

Take a break and try switching brands? It really does make a difference

Hi shelleym1. I started Tamoxifen on September 4, 2015. I was experiencing dizziness so bad that I almost fainted in the supermarket when I got up from a squatting position too fast. My oncologist told me to get up a lot slower - did help, but was still having problems. I also noticed I was getting blurry vision, which I later realized was due to dry eye (something I never had before). Additionally, I became very constipated -- also something new. I finally realized what all of these had in common - dehydration. I have always been good about drinking a lot of water (at least 8 glasses per day), but for some reason, I found Tamoxifen to be extremely dehydrating. I upped my water intake by a couple of glasses - I try to drink 10 or 11 glasses per day - and my dizziness/blurry vision have greatly decreased. I hate having to drink SO much, but when I don't, I start having problems again. I have also read that other women have experienced dehydration with Tamoxifen too. Why don't you try drinking more water to see if it helps? I, too, wanted to ditch the Tamoxifen, however, I didn't do chemo so I am afraid to stop. I am trying to figure out ways to reduce side effects instead - like I am taking colace for the constipation (and also increasing fiber intake). As others have said, maybe you should consider switching brands? Good luck.