Taxotere, Carboplatin and Herceptin

Thanks Minustwo - I have a bone scan coming up, along with a brain MRI. Not sure what that's all about but I guess its the next ring to jump through. I think the pain is due to nerve damage from chemo because so many people on Tamxifen don't seem to have it and that's the only other thing I can attribute this deep flu/fever like pain to. I dont have fever or flu.

I am still getting Herceptin but my teeth appear to have made it through chemo okay. I missed my annual cleaning in July. I need to go, but now MX in October.  My fingernails are pretty brittle though. I take Biotin too 

PMR53. 

going to dentist Monday, gonna get a cleaning and discussing the prolia shot and any SE. That could be a problem to watch for.

I wear a night guard now for about 8 years due to grinding, so for me it's a natural thing. Keeps my jaw from being sore.

Minustwo - I got the message but will have to check with my insurance company to see if they are providers. Thanks!

dentist explained what he knew about prolia, felt very satisfied with his answers, the necrosis that occurs, is from major dental extractions, root canals, implants. And in time, the necrosis can heal too. So with good cleaning, and no issues, proceeding with prolia shot.

Just a note on Prolia. I've had 3 injections so far. I go to the dentist at least a week before the shot just in case I need to do something invasive like root canal, etc. My dentist was the one who wanted to see me before the shot. You can always put off the shot for a month or 2 and get your dental work done. But once you have the shot and you need something invasive you aren't playing with the best odds.

I'm a newbie to this site... and a bit overwhelmed with over 626 pages of posts in Herceptin, Carbo and Taxotere thread alone... please forgive me if I'm asking in the wrong place, or asking something that's been addressed elsewhere! I was diagnosed with triple positive BC in Oct and began a regimen of Herceptin weekly for 52 weeks, and 6 rounds of Carboplatin, Taxotere and Perjeta every 3 weeks. In order to get the Perjeta I had to do this prior to surgery so I took my first round a month ago and had violent diarrhea that did not respond to any meds. I was having 12-20 episodes a day. The Dr gave me fluids and sent me home instead of doing the first Herceptin only treatment. Then we started testing each drug to find the culprit. I did one week of Herceptin alone and had no problem. Next I did Herceptin plus Carboplatin. No real serious issues.... a little diarrhea for 2 days but controllable with meds. This week I had Herceptin plus Taxotere. Same basic thing except I only got a half dose of Taxotere as he thought that would be the culprit.

I'm becoming concerned that it might be the Perjeta, which is the whole reason I waited to have my surgery and the real hopeful drug he felt would do me wonders! I'm wondering if anyone else is on this 4 drug combo and experiencing severe diarrhea that would not respond to medication, and if so, which drug caused it for you? If there is a separate thread for this combo please advise! The Dr told me they are beginning to see this more now and I'm thinking that the HCP has been around quite a while and it's the Perjeta that's the new player, so quite possibly that's the problem? Just wondered if anyone had any experience in this area?

Thanks so much!

Dear GraceN, Welcome to the community. We are sorry that you are dealing with side effects but we are glad that you reached out here. Here is some additional information on Perjeta. Keep us posted on how things go. The MOds

Grace - I had TCHP together for 6 rounds. The Big D was horrible until I went to the BRAT diet like Lago mentions and got proper meds from my MO. Taxotere also causes diarrhea in may people. Whatever, I ended up losing 60 lbs. I asked for extra saline with every infusion. Also went back between infusions for more extra saline & was able to stay hydrated. You didn't say if you are hormone positive too. If so, you have other avenues available to attack your cancer. I didn't, since I was only HER2 positive - so I kept on for the entire 6 rounds.

I was to have H & P every 3 weeks for the year after surgery, but unfortunately I got CIPN (neuropathy) from the drugs. One of the SEs of Perjeta is neuropathy so I chose to drop it after the first 6 main doses. Hope you can get the "D" under control.

Grace: This thread isn't particularly active right now, but there are lots of good comments & posts. I expect there are several women (like me) who keep it on their "favorites" list and would answer if you copy your entire post over there. Neoadjuvent TCHP

https://community.breastcancer.org/forum/80/topics...

Thank you so much for your response! Good to know it can let up eventually. My Dr seems to think we need to find which one caused me this violent a reaction and then adjust the cocktail accordingly but since he gave me a half dose this week of the Taxotere, I'm not sure if I can say for sure if this is the biggest problem or not. It did give me some D for 2 days but it was controllable whereas the first full round it was not. Perhaps my body will eventually just get used to it like yours did and I can stay on this routine. So many unknowns! I find Taxotere to be hard on my in many ways though. I get a tightness in my chest and racking pains that come from my back around my ribs. Just awful pain, but fortunately they are short lived but scary when they come! Anyway... I go back Monday for the Herceptin and Perjeta alone "test" to see if that's it. I really thought it would be Taxotere but now I don't really know. They all cause it some! LOL! Thanks for the help!

did not have perjetta, but still had diarrhea too, so your cocktail will be what the dr is trying to rule out.

As for the dental issues, will talk to dr after holidays, cause when I bite on hard things like nuts, this tooth hurts, so am hoping it's not cracked, nor the gum/jaw either, but something is up

Grace - I didn't get Perjeta, because, like Lago, it wasn't available 5+ years ago when I received treatment, but I did get the Taxotere, Carboplatin and Herceptin, I had a little diarrhea while getting the chemos for a couple of days nothing bad. But mainly I wanted to say that I'm here and still no evidence of disease 5 1/2 years later without the perjeta, so if you have to stop that med, the other 3 are still very effective for most people.

Linda

I was a TCH peep without Perjeta, since it had not been approved yet, and had the Big D for ten days straight after each of the six infusions.

Grace. Abraxane does have SE but not as many as Taxotere. It's more expensive so insurance will not pay unless you have to have it. Like in your case you can't do Taxotere. Don't worry. You are getting good shit