BRCA negative? Consider panel testing!

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vlnrph
vlnrph Member Posts: 1,632
edited February 2016 in High Risk for Breast Cancer

People with significant family history who did not have "the" breast cancer mutation were found to have defects in other genes. Pre and post counseling is recommended according to this report from the 2015 American Society of Clinical Oncology BC symposium.

http://meetinglibrary.asco.org/content/155266-163#


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  • countryfrenchrose
    countryfrenchrose Member Posts: 48
    edited October 2015

    I wish that my OB/GYN had tested me 5 years ago when I asked him to. He refused said I did not need it. I had Variants of Unknown Signigicance discovered when tested after I was diagnosed with stage 2 or 3 BC July2015. When I read the literature about my VUS they were all associated with BC in some reports and were for genes that are part of BRCA functions. I would have had forewarning and might have found the cancer sooner .

    For all the costs of chemo and surgery gene testing should be standard of care, the focus on mammography only is a problem

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  • 614
    614 Member Posts: 851
    edited October 2015


    I have a V.U.S. but nothing is known about this mutation, unfortunately.

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  • marijen
    marijen Member Posts: 3,731
    edited July 2016

    That's right country fresh rose, how can a mammogram detect an underarm lymph node, by then it's invasive. I'm starting to notice how many doctors think this is all no big deal, even the females and nurses.

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  • Linny50S
    Linny50S Member Posts: 7
    edited February 2016

    I have a very strong family history of breast cancer and tested positive for NBN mutation. All of my maternal aunts (2) and my mother had breast cancer and later died. I had my mother bank her blood in case another gene mutation was discovered (she did not have BRAC). Her blood tested positive for the NBN mutation. All of my maternal cousins (4) have/have had breast or prostate cancer, linked to NBN and 2 cousins were tested and found to be NBN positive. My youngest sister is also NBN positive. My younger brother tested negative. My younger brother has had colon cancer at age 54 and my younger sister died of colon cancer at 55.I had a prophylactic bilateral mastectomy on Sept. 9, 2015 with reconstruction started. It is now Feb. 28, 2016 and I have to wait until March 24th for my implants, due to having to have my expanders replaced because of a leak and not loosing my drain tubes until Dec. 29th! I do not regret the mastectomy but I hate the pain and discomfort of these expanders. Reconstruction is not for the faint of heart.

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