NSAIDS and Breast Cancer

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123JustMe
123JustMe Member Posts: 385
edited May 2018 in Clinical Trials, Research News, Podcasts, and Study Results

Breast cancer recurrence and aspirin use

http://jco.ascopubs.org/content/28/9/1467.abstract

Aspirin & breast cancer clinical trial

http://www.dana-farber.org/Newsroom/News-Releases/...


NHI study

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC317826...

Pubmed info

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0041179/


Links to other studies BCO threads:

Topic: Paravertebral Nerve Block and Propofol Sept. 2015, by Falleaves

https://community.breastcancer.org/forum/73/topic/834546?page=1#idx_15

Topic: Effects of opioids on cancer progression Sept. 2015, by Falleaves

https://community.breastcancer.org/forum/73/topic/835291?page=1#idx_

Topic: ketorolac to reduce recurrence Mar. 2014, by Falleaves

https://community.breastcancer.org/forum/91/topic/818961?page=1#post_3936891

Topic: Anesthesia and recurrence of cancer Sept. 2015, by Fallleaves

https://community.breastcancer.org/forum/73/topic/835244



https://m.youtube.com/watch?v=IkKEFF_c0yo


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  • Kathy044
    Kathy044 Member Posts: 433
    edited September 2015
    Try this link for info about the new Dana-Farber randomized aspirin clinical trial (the one listed above didn't work for me)

    http://www.dana-farber.org/Newsroom/News-Releases/could-aspirin-treat-breast-cancer.aspx

    Kathy
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  • 123JustMe
    123JustMe Member Posts: 385
    edited September 2015
    Thanks. I have posted this link.
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  • Fallleaves
    Fallleaves Member Posts: 806
    edited September 2015

    Thanks for posting these, 123JustMe. Interesting the difference in effect between aspirin and ibuprofen in the NHI study.

    Your top study led me to this meta-analysis, which lumped together aspirin and other NSAIDS. In 16 studies included there was a significant reduction in recurrence/metastasis, and breast cancer mortality for post-diagnosis aspirin users (25%, and 31%, respectively)

    http://www.ncbi.nlm.nih.gov/pubmed/25701248

    (Chen, 2015)

    I'm excited to see a randomized controlled trial going forward at Dana Farber! Hope it turns out even better than expected. It would be so nice to be able to provide a lot of benefit for only pennies a day.



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  • 123JustMe
    123JustMe Member Posts: 385
    edited September 2015

    Thanks for the additional study Fallleaves!

    I am so excited that there will FINALLY be a study looking at aspirin and breast cancer!

    I have a feeling that it will reduce the recurrence 😀

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  • CAMommy
    CAMommy Member Posts: 437
    edited September 2015

    so aspirin is associated with a decrease but ibuprofen is associated with in increase? That's rather scary. I'm an ibuprofen taker.... Maybe I should switch to aspirin.

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  • Fallleaves
    Fallleaves Member Posts: 806
    edited October 2015

    123, I just ran across a paper that may help explain some of aspirin's superpowers! The article I read was about the anti-inflammatory effects of omega-3 fatty acids and their benefits in fighting cancer. But it also mentioned some intriguing things about aspirin. Beyond aspirin's ability to inhibit COX-2 activity, and thus inflammation, it also converts the constituents of omega-3's (EPA and DPA) into molecules called resolvins and protectins. Here's more from the paper:

    "...as newer studies attempt to elucidate the roles of these molecules in inflammatory diseases, more interactions with signaling pathways and connections to biological processes closely tied to oncogenesis and cancer progression are being found. Both the resolvins and protectins reduce inflammation by blocking neutrophil transendothelial migration and neutrophil infiltration (Serhan et al. 2008). In recent years, neutrophils have been found to play critical roles in tumorigenesis through their production of inflammatory cytokines in the tumor microenvironment (Gregory and Houghton 2011). One of the major mechanisms of action by which the resolvins and protectins fight inflammation is via interference with the tumor necrosis factor (TNF) pathway."

    www.researchgate.net/publication/264631516_Breakin...

    (Patterson, 2014)



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  • Anonymous
    Anonymous Member Posts: 1,376
    edited October 2015

    recent study came out and recommended a daily aspirin for people over age 50 to help decrease colon cancer; so another good reason to take it (also helps decrease risk of blood clot and heart attack)

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  • 123JustMe
    123JustMe Member Posts: 385
    edited October 2015
    Wow! That is interesting research Falleaves!
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  • Jerseygirl927
    Jerseygirl927 Member Posts: 438
    edited October 2015

    kinda of glad I ran across this thread, years ago 1993 to be exact my heart dr suggested an aspirin a day for overall heart health, I have not kept up as I should, probably did 3 times a week for a few years, then when the cancer occurred I just stopped, think, I may go back on this. Like the odds.

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  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited December 2015

    Bump

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  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited April 2016

    Replaced this post 123JustMe with a link to the thread where I consolidated the info to take to a doc. Thanks, sassy.

    https://community.breastcancer.org/forum/73/topics/843381?page=1#idx_4


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  • Jerseygirl927
    Jerseygirl927 Member Posts: 438
    edited January 2016

    I have read this, found it most interesting, having no formal medical training, I am glad so much study has been done on this, I hope that more pro-active test are done on this same level in the hopes of concurring that kerotolak has significant effect on preventing relapse cancer tumors.

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  • ChiSandy
    ChiSandy Member Posts: 12,133
    edited January 2016

    I gave up NSAIDs (except for low-dose daily aspirin for cardioprophylaxis and celecoxib--a COX-2 inhibitor--for hip pain from muscle tears) when I got a GI bleed (dx after endoscopy was gastric erosion “of probable chemical origin" and esophageal irritation) after taking them after weaning myself off opioids & gabapentin after my knee replacement surgeries; I’ve never looked back. Hoping my daily low-dose aspirin, supplemented by occasional celecoxib, is protective against tumor recurrence.

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  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited March 2016

    Bump


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  • muska
    muska Member Posts: 1,195
    edited March 2016

    I have been on baby aspirin - every other day - for almost three years now. That was my MO's recommendation as a possible preventive tool. I was told some studies showed no difference between daily and every other day regimens.

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  • slv58
    slv58 Member Posts: 1,216
    edited March 2016

    I wish I could take aspirin but I can't take any blood thinners 😔

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  • Jerseygirl927
    Jerseygirl927 Member Posts: 438
    edited April 2016

    heart dr told me baby aspirin when I was n my 40's. Still take daily, was lax be fog I got breast cancer. Now I don't miss a day

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  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited May 2016

    Bump

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  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited May 2016

    Bump

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  • 123JustMe
    123JustMe Member Posts: 385
    edited May 2018
    • More research on Toradolfrom 123JustMe May 21, 2018 02:23PMKetorolac Lowers Breast Cancer Risk in Patients With Elevated BMI
      Journal of the National Cancer Institute.
      Save Recommend Share Get Topic Alerts TAKE-HOME MESSAGE
      • This retrospective series was designed to evaluate the impact of intraoperative nonsteroidal anti-inflammatory drug use on breast cancer recurrence. Patients receiving intraoperative ketorolac (but not diclofenac) appeared to have a reduced risk for distant recurrence (HR, 0.59; P = .03).
      • The reduction in distant recurrences was particularly pronounced in patients with an elevated BMI given ketorolac.– Neil Majithia, MD
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  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited May 2018

    123, Thanks for posting it on the sister threads. Amazing results

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  • 123JustMe
    123JustMe Member Posts: 385
    edited May 2018

    Hope others are paying attention to the importance of Ketolorac

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