Drug Combo Effective for Metastatic HER2+ Breast Ca

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besa
besa Member Posts: 1,088
edited August 2015 in Clinical Trials, Research News, Podcasts, and Study Results

http://www.medpagetoday.com/HematologyOncology/Bre...


"The combination of lapatinib (Tykerb) and trastuzumab (Herceptin) is active and well-tolerated when given to patients with human epidermal growth factor receptor 2-positive (HER2) metastatic breast cancer (MBC) who have received up to two lines of therapy for advanced disease, a nonrandomized phase II study now shows.

What's more, early metabolic imaging by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) appears to provide the key to selecting patients who can be treated with targeted regimens and spared the toxicity of chemotherapy, Nancy U. Lin, MD, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, Ma., and colleagues report online in the Journal of Clinical Oncology."

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  • letranger
    letranger Member Posts: 234
    edited August 2015

    My clinical onc told me that Nancy Lin is the one to follow for Her2+ brain mets. She said that the Tykerb + xeloda combo was promising in her early trials and that's why she is now trying out neratinib + xeloda. I am on this regiment and hoping for great success to clear those mets. Scans are in about 6 weeks.

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  • Nel138281
    Nel138281 Member Posts: 2,124
    edited August 2015

    I have been on herceptin/tykerb combo for 2 years. I have been NED for almost 2 years. A combo with some se's certainly ,but have been manageable

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