Confused on hormone receptor status

bjclaywell
bjclaywell Member Posts: 49
edited June 2015 in IDC (Invasive Ductal Carcinoma)
Confused on hormone receptor status
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  • bjclaywell
    bjclaywell Member Posts: 49
    edited June 2015

    I received the "amended" pathology report today, and it states the following:

    ER - 100% 3+ nuclear staining (POSITIVE)

    PR - 100% 3+ nuclear staining (POSITIVE)

    HER2/neu 1+ membranous pattern (NEGATIVE)

    I understand that the 100% means all the cells they tested were ER and PR receptive - but what is the 3+ staining?    Is that the second part of the Allred Score I've read about?  If so, does that give me an Allred score of 8?

    Thank you in advance for your help, everyone!! 

    Bobbi Jo

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  • SpecialK
    SpecialK Member Posts: 16,486
    edited June 2015

    When testing is done to determine hormonal receptor status they use a staining technique that results in both a receptor percentage and a staining intensity.  Staining intensity indicates how well the receptors show up - so your ER and PR testing showed strong intensity, your Her2, less intensity.  Yes, this relates to the second part of the Allred score.  Linked below is a good explanation of how Allred scoring works.

    http://medical-dictionary.thefreedictionary.com/Allred+scoring+system


     

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  • bjclaywell
    bjclaywell Member Posts: 49
    edited June 2015

    SpecialK - thank you so much! That was the same site I found which clarified it for me! I appreciate your clarifying what the terms mean, and for verifying my thought process! Very helpful. Much appreciated.

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  • SpecialK
    SpecialK Member Posts: 16,486
    edited June 2015

    Glad to help, best of luck with your treatment going forward!  If you have more questions, just ask!

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