Ibrance (Palbociclib)

Hi all, wow this thread has been busy! Thank you so much for the info on the conference, I will definetly be listening☎️☎️☎️.

This weekend has been wonderful. DIL and DS are here and we had my DILs baby shower. Happily beyond belief, I was there, well, and able to enjoy every fabulous moment. Had it at a country club so there was minimal muss and fuss by me. They did all the cooking, cleaning up and serving. I know it was a splurge, but worth every dime in terms of health.

Sandilee, I know how frustrating it is to wait to restart! I have done it also, but as my RN told me while I was bitterly complaining: what good is a dead patient taking Ibrance? In her callous way, she is correct, try to stay calm and take your supplements.

To all dealing with TMs: UGH! Mine have been up and down like the Ibrance roller coaster we are on. Hold on to your hats, hopefully it will be a long ride.

That's all for now....Enjoy your BBQs and swimming pools and whatever wonderful things life has to offer. Myra.

Holly, so very sorry you're experiencing this! It must be difficult, too, to try to eat in such a way as to not get heartburn, and then to try to fit your meds in with all that. I can imagine how alarming your symptoms must be.

I haven't had any heartburn or other problems when I took the combo, or Letrozole alone, except the occasional headache. I hope this can pass soon for you. It's unfortunate that you can't take your usual for heartburn, as the Zantac doesn't seem to be working too well for you. Have you explored causes unrelated to cancer with another specialist? It's a nuisance because we are in the doc's office so much already, but it might give you some relief if they could find the cause, or at least prescribe something that works more consistently that is also suitable to use with the Ibrance.

Holly I did have very slight nauseau when I took the Ibrance in the morning.  So I started taking with dinner and have not really had any problems since.  Also I have not had any acid reflux since on Ibrance/Femara. Strange but I did have on my prior treatment, but that seems to have stopped.  When I first started on Ibrance I had some slight headaches, but haven't had since the second cycle.

Holly. Sorry about the nausea. Have some mild nausea occasionally. As Hope said, I take it after dinner on a full meal. Myra

Holly, I've been having what I would call irritation in my esophagus,on Ibrance where I never had reflux or much indigestion before (except during chemo, but that's not surprising). It comes and goes and doesn't seem to relate to the pill timing. I even had it the first few days of my off week. It's hand in hand with increased nose and tongue irritation and sort of a cough when I breathe deep so I think it's just an Ibrance cell turnover thing.

For me it's annoying, but I can imagine it would be much worse when you already have reflux issues. Hope you find a way around it soon. Hang in there

Holly, my reflux/irritation in my esophagus is very much like what Roses described. Started to be really noticeable during my off week between rounds 2 and 3 and at the beginning of round 3. I did not have it before so I'm pretty sure it's either Ibrance or letrozole related? Annoying but so far manageable.

Thanks for that input, Kaydeesmile and Romansma, I am keeping it all in mind and will have to experiment and see what works. Actually didn't have it last night, so that was a relief. A friend just told me bisphosphonate drugs can cause ulcers ( Zometa is a bisphosphonate drug and I have been on it for a year). So it could be many or all of these things combined.

Romansma, I hope the infrared sauna will give you some relief soon. Praying for everyone, and thank you so much for all your great advice!

Liz so sorry that the Ibrance didn't work for you.  I know firsthand how disappointing it is to fail on a drug that holds so much promise.  I'm also concerned regarding the Femara.  I have taken it in the past and was NED for five years.  But of course I'm concerned now that since I've had Femara in the past, the combo won't work as well.  But I will just have to be patient and see.  Just curious, had you discussed with your onc the possibility of combining the Ibrance with Faslodex?  My onc had indicated that would be a possibility

Good luck on Halaven.  It worked for me for over a year.  I felt great on Halaven, but I caution on to stay on top of the neuropathy.  I made the mistake of not telling my onc until the neuropathy got so bad I could barely walk.  That was six months into it.  He then reduced the dose and gave it every two weeks.  I am still annoyed with myself that I didn't mention that sooner.

Praying that you do well on Halaven.

Sorry it did not work out for you Liz. I pick up mine tomorrow (With the Pfizer card!). Good luck with Halavan. Is that a Her+ drug?

Well, shoot, I have to delay cycle three because of mouth sores. Onc says I have to wait until they are completely healed, then resume on a reduced dose. I was too cavalier and didn't pay attention to taking care of my mouth. Gosh, I love potato chips.

My recent scan and TMs were good.

welcome Zimmerwoman. Good luck with Ibrance. Started cycle 4 tonite. Lenn, can't believe you said that about hydration. I had a very similar experience at the end of last cycle. They gave me the Xgeva shot when my counts were down. I got out of the car and reached for the door knob and my knees were about to buckle and I was shaking. Did not feel better til I drank enough water. Flushing out these meds is paramount!

Shetland Pony, sorry about the mouth sores, but good news on scans and markers.

Have a good nite all...Myra.

Welcome, newbies!

Stefajoy, you are the only other person I have heard of that was given Faslodex and Aromasin as first line therapy. I hope my run is as long as yours! Are all of the Pfizer programs income-based? Good luck with your appeal. I am going through that whole drama myself.

Myra and Lenn, I will heed your warning about staying hydrated. Thank you!

Hello, Stefajoy!

Ok. I asked hubby. He said the co pay card is only valid if your insurance approved it and pays some. Then Pfizer drops the co pay down for you.

So far, we have a flat out denial.