PETITION - Assess Bazedoxifene (BZA) in treating breast cancer

Dear all,

I have exciting news. To introduce myself, I have been associated with the research conducted at Duke evaluating the potential of bazedoxifene in breast cancer treatment since the beginning, and it has been both amazing and humbling to see it evolve. 2 years ago, I started communicating with you courageous ladies on this site, mostly because I wanted to correct misinformation that was being spread after our initial results presented at Endo 2013 were well-publicized. I did not know then when I might ever be able to post the following:

http://clincancerres.aacrjournals.org/cgi/content/abstract/1078-0432.CCR-15-0360.

I post this here only for information, not for self promotion. we have conducted follow-up studies, at Pfizer's request, on the potential usefulness of combining bazedoxifene with palbociclib, the venue in which Pfizer chose to develop bazedoxifene for breast cancer treatment. You might recognize palbociclib as being one of the drugs combined with letrozole in the Paloma trials that led to the FDA to fast-track palbociclib for breast cancer treatment. This research was a team effort combining resources here at Duke and also at Washington University in St. Louis. The results are really exciting. While both bazedoxifene and palbociclib alone were very effective in tumor models (studies done in animals) representing breast cancers resistant to tamoxifen or derived from patient tumors that had progressed during multiple endocrine therapies, the combination of these two drugs was really quite powerful. Based upon these results, Pfizer has opened a clinical trial of this combination therapy.

https://clinicaltrials.gov/ct2/show/NCT02448771?term=bazedoxifene&rank=1

Obviously, there are inclusion/exclusion criteria. Among them are that patients will have progressed during one or more endocrine therapy (ie tamoxifen, faslodex or aromatase inhibitor), and that patients will not have previously taken either bazedoxifene or palbociclib alone.

One of the posters here asked whether the petition had done any good. Without the interest shown to Pfizer with all of your calls, letters, requests for compassionate use, and the petition, I really don't honestly know whether this drug would have gotten this far. You are a very passionate and powerful community, and I would really feel honored if some of the work that we have done can directly benefit any of you.

Best of luck to all.