AC+T SEs

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  • littleblueflowers
    littleblueflowers Member Posts: 2,000
    edited May 2015

    Looking carefully at my patchy bald crew cut, it looks like my hair is actually growing back. Like the old dark hair is jumping out but tiny blond stubble is replacing it. How annoying. Am I going to be shedding continuously for the next 10 weeks? I'm heading into AC 3 of 4 thursday...

  • rleepac
    rleepac Member Posts: 755
    edited May 2015

    My last period was a week before I started AC. Nothing since and I'm ok with that. I was peri-menopausal before BC diagnosis anyway so maybe the chemo was just enough to push me over the edge into chemopause?

    Bekah

  • rleepac
    rleepac Member Posts: 755
    edited May 2015

    Just had first Taxol (with Herceptin and Perjeta) 4 days ago. Saw MO during infusion and he said something about maybe only doing 8 instead of 12 Taxol 'depending on how you handle it'.

    Now I'm confused...if 8 is enough, why is the protocol 12? If I need 12, why would he cut it off at 8? Could it be because I had an allergic reaction to the Taxol? He sort of suggested that it might be up to the BS but kinda brushed over that. He did say we could switch to Abraxane if I have another allergic reaction this week but I was doped up on Benadryl from the allergic reaction and wasn't thinking straight.

    Anyone have any thoughts on this? SpecialK...are you out there?

    Bekah

  • Kicks
    Kicks Member Posts: 4,131
    edited May 2015

    I saw my Chemo Dr before my 10th Taxol. I talked to him about how completely and utterly exhausted I was (existed either in bed or on couch in front of TV). He told me it was ip to me me IF I felt I had to stop he was going to put in an order that I could IF I decided I needed/had to stop as the 9 I had already done had done 85% of what doing the 12 could do. Having already done 9 and 85% - I was not going to stop with only 3 more to do and get 100% of what it could do.

    I was more fortunate than some as I did not have 'anything' I had to do other than fight the 'Monster' as Hubby took over all cooking, house and dog chores and Son took over all horse/barn chores. I h

  • Chloe2015
    Chloe2015 Member Posts: 14
    edited May 2015

    Hi everyone. I am newly diagnosed and supposed to start chemo this week. I am very worried about some of the side effects, including infertility and "chemo brain" (deterioration in short-term memory that could be permanent). Can any of you tell me your experiences or what you know about either of these side effects? Seems like these could be permanent! Thanks so much.

  • Kicks
    Kicks Member Posts: 4,131
    edited May 2015

    We each have our own uniques issues and no 2 of us have exactly the same experiences. Do not assume that the worst that you read you WILL experience.

    You say you are worried about infertility - have you talked to your Dr about having eggs 'harvested' before Chemo? It was not something for me to worry about as I was 19 yrs post menopause when DXd but there are some going women here who have.

    'Chemo Brain' - Can't say I had any issues but I'm A.D.D. (DXd) anyway. Hubby and Son said they didn't see any difference in me that way during either the neoadjuvant A/C or adjuvant Taxol.

    A/C was not bad at all - did not slow me down at all. I did loose head hair, lost sense of taste and smell, lost appetite (no nausea - just never thought about eating). Taxol wasn't as nice - completely and utterly exhausted the entire time. For some it is the reverse - A/C is worse than Taxol. We are all unique and there is no 'One Size Fits All'.

  • Chloe2015
    Chloe2015 Member Posts: 14
    edited May 2015

    kicks - thanks for your reply. I am going to try the cold caps and see how it works out

  • KBeee
    KBeee Member Posts: 5,109
    edited May 2015

    rleepac, I do not know how they came up with 12 Taxol. If you compare the dosage for those doing dose dense 4 Taxol (175 mg/m2) to the weekly, (80 mg/m2) then when on the weekly, you have exceeded the dose dense total by week 9. When they compared the toxicity nad efficacy of the two, they had people do 6 dose dense treatments so teh time frame was the same...so it did not compare the 2 standards in use. I never understood that. So 12 may be better than 9 long term (who knows), but if you have done 9, you still have gotten more of the drug than those on the dose dense regimen. Best of luck. I start weekly Taxol at the end of May. I am worried about neuropathy since I just competes Taxotere in 2013.

  • littleblueflowers
    littleblueflowers Member Posts: 2,000
    edited May 2015

    Ok, new side effect for me here...my feet. They are so sore and beat up! I feel like I'm growing giant painful calluses way faster than normal, and they are just tender after being on them all day yesterday, with blisters and hot spots all over. I'm a runner and an ex wildland firefighter, so I'm used to having my feet get beat up, but this is just from walking around. Right now I'm l trying to figure out how to bandage them up for another busy day. Any suggestions? This has to be the chemo...

  • Trvler
    Trvler Member Posts: 3,159
    edited May 2015

    LIttleblue: What drug are you on now? Your sig doesn't say. I think since you are triple - you are taking a different regiment.

  • SpecialK
    SpecialK Member Posts: 16,486
    edited May 2015

    rleepac - what kbeee said.  I have a good friend that was TN and she did 9 of 12 neoadjuvently - she really struggled with chemo so she stopped, then had surgery.  As with any treatment it is a cost/benefit analysis.

    littleblue - sounds like it may be hand & foot syndrome, here is a link.  This is relatively common.

    http://chemocare.com/chemotherapy/side-effects/handfoot-syndrome.aspx

    trvler - AC-T is the most common TN regimen.

  • rleepac
    rleepac Member Posts: 755
    edited May 2015

    Thanks. I'll discuss with the BS and MO this week when I'm not doped up on Benadryl/Ativan cocktail and try to get a better understanding of what the plan is.

  • Trvler
    Trvler Member Posts: 3,159
    edited May 2015

    Oh, I didn't realize AC + T was for triple -. So Herceptin is when you are HER+, right?

  • Kicks
    Kicks Member Posts: 4,131
    edited May 2015

    I am ER+PR-/HER2- and did A/C neoadjuvant and Taxol adjuvant. Herceptin is for HER2+.

    There are no absolutes when it comes to our individual TX plan as we are each unique as is our DX. Different Drs also have different thoughts on TX plans. Different types also have different 'usual' TX plans. For IBC, neoadjuvant is the SOP but neoadjuvant is being used more often with other types. Most IBC will do A/C and Taxol neoadjuvant but I did 4 DD A/C neoadjuvant and 12 Taxol adjuvant.



  • Chloe2015
    Chloe2015 Member Posts: 14
    edited May 2015

    I just read that Taxol can lead to permanent neuropathy - that really worries me! Have any of you experienced this as a result of Taxol?

  • littleblueflowers
    littleblueflowers Member Posts: 2,000
    edited May 2015

    Travler, I am doing DD AC and T. Not sure why it isn't showing up on my signature. If this is hand and foot syndrome..ugh. No. Just no. 😠

  • SpecialK
    SpecialK Member Posts: 16,486
    edited May 2015

    little blue - you probably need to go to your profile and change the chemo portion of your treatment from private to public, then it will show up.

  • Kicks
    Kicks Member Posts: 4,131
    edited May 2015

    There is a fairly common childhood disease (hand/foot disease) that is a virus and easily spread that sounds a lot like what you are experiencing. On Chemo, our mmune systems can be very compromised thus easier to contract. This past fall, Hubby developed it (apparently his boss brought it to work as his going child had it at the time). It was horrible and he could hardly stand or walk. It was bad enough that he actually had me drive him to the Dr (I usually have to fight to get him to go to a Dr for anything). I did not remember what the Podiatrist gave him for meds but they did start working within days and it took about 3 weeks to be healed. I was warned to be on the watch for it 'just in case' though I had not been on Chemo for almost 5 yrs.

  • placid44
    placid44 Member Posts: 497
    edited May 2015

    Chloe,

    I am two years and four months post taxol and I have mild neuropathy in my feet. Some in my legs, but that has improved a bit since treatment. It doesn't keep me from doing anything I want to do. It's a tiny bit uncomfortable. I'm still glad I did it because I didn't get as much tumor shrinkage on AC. I needed the taxol. I don't know yet whether it's permanent

  • Trvler
    Trvler Member Posts: 3,159
    edited May 2015

    Placid: I am sorry you are still having neuropathy issues. I haven't started Taxol yet so I don't know if there is anything to help with that. Do you do any exercise? I am glad you posted that because I am not feeling my tumor do much under the AC.

  • SC_Coqui
    SC_Coqui Member Posts: 133
    edited May 2015

    I had a fairly easy time on AC. I had nausea and took Zofran and Phenegran to alleviate it. After 2 days it was gone. My first infusion was the worse as far as chemo brain goes, but I also had my port put in the same day as the infusion, so I think that had a lot to do with it.

    The steroids made me super hungry all the time.

    The last AC infusion was the worse as far as SEs with a burning sensation lasting in my mouth a few days and my taste buds pretty much being decimated. I've noticed over the past few days (12 - 13 days after the last infusion) I can feel my taste buds coming back. I've also had heartburn this past go around and have been taking Zantac.

    I still have some eyebrows and lashes left. My MO said that they may disappear on taxol and that taxol will affect nails a lot worse than AC did.

  • Trvler
    Trvler Member Posts: 3,159
    edited May 2015

    You didn't have your first Taxol yet, right, Joanna?

  • SC_Coqui
    SC_Coqui Member Posts: 133
    edited May 2015

    I haven't. I'm in the chair right now getting my pre-meds and waiting for my taxol.

  • Trvler
    Trvler Member Posts: 3,159
    edited May 2015
  • ThePrincess
    ThePrincess Member Posts: 424
    edited May 2015

    Good luck Joanna! Thinking of you and hoping it goes well.

  • rleepac
    rleepac Member Posts: 755
    edited May 2015

    I had a follow up with the BS at UCSF and she couldn't stop smiling at me and she told me twice how I was rockin the earrings ;) I went commando because I figured nobody in S.F. cares if I have hair or not but I couldn't go without earrings!

    Anyway...we are on track for me to finish the last 10 rounds of Taxol/Herceptin and then will repeat scans (chest CT, mammogram, breast MRI) and BMX will be scheduled for the week of Aug 17. She said she only sees a slim chance I'll need rads but she is going to take it to the tumor board after the repeat scans. She said probably an overnight hospital stay and then 3 weeks recovery.

    Overall I was happy with the visit and the rest of 'the plan' is starting to take shape.

    Bekah

  • rleepac
    rleepac Member Posts: 755
    edited May 2015

    My tongue is sore but no tingling in fingers or toes (right now).

    Anyone else have a sore tongue? I think it's neuropathy but only on my tongue - weird.

  • SC_Coqui
    SC_Coqui Member Posts: 133
    edited May 2015

    I was feeling perfectly fine yesterday, but today I'm a little woozy this afternoon. Hoping that some food in my belly will make me feel better. I don't have much of an appetite since my tastebuds are shot.

  • molly1976
    molly1976 Member Posts: 403
    edited May 2015

    Bekah, I've had a sore tongue on occasion. I think in my case it might be due to mainlining a perhaps slightly larger quantity of Jolly Ranchers per day than advisable. I've since cut back on super sugary or acidic things and have not had much trouble since.

  • littleblueflowers
    littleblueflowers Member Posts: 2,000
    edited May 2015

    That freaking sore throat...hits around day day 3 with the swollen glands and the mouth sores...is usually gone by about day 9. And the constant low grade nausea. Even with prilosec calfate, zofran, and cpmpazine....Ativan puts me to sleep...and the freaking lead legs....and the giant purple circles under my eyes....and the fstigue....and the no sex drive, no alchohol, no nothing......only 5 more....goddamit.. only 5 more....God I feel like shit!

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