Inconsistent test results

I was geared up to do Taxol and Herceptin based on a positive FISH HER2 test on biopsy (IHC was equivocal), along with grade 3. Testing on my mastectomy specimens however were negative by dual ISH (again IHC equivocal). An Oncotype done on the biopsy specimen, without my knowledge, that was not in the record, was just discovered, and has HER2 negative. At this point my doctors are considering me HER2 negative but I have concerns.

I am ER/PR positive, 95% ER and 80% PR.

The other testing inconsistency is that the just-discovered Oncotype Dx done on the biopsy specimen shows a low recurrence score. The pathologist at the hospital that ordered it thinks this is weird, since my ki67 was high, grade there was 3, and I had lymphovascular invasion.

Pathology done on mastectomy specimens showed ki67 high at 20% (low end of high), grade 2/3, Her 2 1+/2+ on IHC and 1.2 on dual ISH (very different from the 2.1 obtained on the biopsy), mixed ductal and lobular in invasive part and CIS, DCIS with necrosis, lost e-cadherin in lobular parts, focal LVI.

For weeks since my mastectomy I have been told I would be doing Herceptin and Taxol then hormonal treatment. I have not had radiation though it was mentioned at a second opinion in passing, due to LVI, but they said 4/5 radiology onc.'s would not suggest it.

Due to the low Oncotype score, which I do not trust, I am now told that I will only do hormonal treatment. I want a new one done on the surgical specimen versus biopsy (which may have had more DCIS on slides, which could account for the lone HER2+). Does anyone else have highish grade, highish Ki67, and low Oncotype score.

I am not eager to do chemo, don't get me wrong. If anything I would be interested in Herceptin with the ambiguous HER2- I have read that it can be taken alone.

I have had two opinions (two hospitals in the same system) and my biopsy pathology was done in another hospital.

I am confused and still worried whether hormonal treatment is enough in the context of some of my test results, especially grade and ki67. I am also confused as to why the Oncotype of the biopsy material is determining treatment when the HER2+ from that sample is being discounted (with the explanation that the Oncotype has it as negative- wouldn't a FISH be more reliable? IF DCIS in the sample explains the HER2+ wouldn't it also affect Oncotype and make it lower?)

I know this is complicated and apologize if this is too much to post. If anyone else has had these inconsistencies would love to hear your treatment and outcome so far. Thank you!