PAC-1 Phase 1 Trials open
Clinical trials for a possible weapon against cancer are open, see link:
https://www.clinicaltrials.gov/ct2/show/NCT02355535
My wife just had her second dose of A/C. The usual hair loss, nausea, etc. She had a radical mastectomy and 19 lymph nodes removed. Her rather benign ER+ cancer of the right breast mutated because her estrogen blocker aromasin stopped working. It had become an aggressive type 3 tumor. She has to take tamoxifen now. In 9 of the 19 lymph nodes removed they found triple negative metaplastic keratinized squamous cell breast cancer. It had spread out of the lymph nodes into the surrounding tissue. Her options are few as she is very allergic to taxol and almost died from it. One positive note she's had, just a day after her infusion, for a short duration terrible pain where the cancer is located. Maybe it was being killed.
Comments
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I just read about PAC-1 last night. Here's the link:
Cancer drug (PAC-1) first tested in pet dogs begins human trials
Best of luck with your wife!
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Vanquish Oncology touts PAC-1's ability to cross the blood-brain barrier as one of its major advantages. This would potentially makeit a treatment for primary central nervous system malignancies as well as metastastic disease in the CNS. Why then does their phase 1 trial exclude people with primary or metastatic brain lesions?
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