Breast cancer: two new genetic risk factors uncovered

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  • DiveCat
    DiveCat Member Posts: 968
    edited February 2015

    I am really glad they have started to do more research into SNPs. They are less smoking gun than finding a big mutation, like BRCA was, but might explain many of those with hereditary risk who do not have a known mutation. I find the issue of SNPs and breast cancer risk to be a very interesting area...but in large part it has not attracted as much focus as looking for the big mutations, and in part because it tends to a muddier area! I had genetic testing done that looked at SNPs for research purposes only since I come from a BRCA- family, and it came back with a few variants that had/have been "linked" to BC risk in a select number of studies (including several rarer variants in ATM, PALB2, BRCA1 locus and some less rare individually, but several of them, in FGFR2 etc), but research still is not certain enough nor are their clinical recommendations (my high risk status and recommendations were based only on family history, not this testing) or to even know how they work together or don't.

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