Anyone on Taxotere, Perjeta and Herceptin

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  • Jmo06
    Jmo06 Member Posts: 159
    edited October 2014

     Thanks TJG2 will certenily need it =)

  • pamelalea1110
    pamelalea1110 Member Posts: 2
    edited December 2014

    I have just had my first Perjeta +TCH treatment and so far I am doing ok. I am very anxious about the prospect of losing my hair. Can anyone tell me if you lost all your hair or just some? The website says that 55% percent of patient in the clinical trial lost their hair , all grades but none to the severe level, grades 3 and 4. What has everyone experienced?

    Her2+, Stage 1B, 2cm, no nodes positive


  • CassieCat
    CassieCat Member Posts: 1,257
    edited December 2014

    Pamela, I lost almost all of my hair on the same regimen. It started shedding around day 15-16 of the first round. I still have some, but it is very sparse. Three of the four agents have hair loss as an SE, unfortunately.

  • Jmo06
    Jmo06 Member Posts: 159
    edited December 2014

    mom finished chemo but no will be on lifelong treatment of herceptin and perjeta anyone else on this?

  • Teakie88
    Teakie88 Member Posts: 226
    edited December 2014

    I was on the Taxotere, Herceptin, and Perjeta and tolerated all the treatments very well. I will be on H & P for life as well and have had no noteworthy side effects as of yet, and am also very grateful that these targeted therapies are available for us. I also lost all my hair after first treatment from the Taxotere only, but now hair is regrowing. Ann

  • mikarae
    mikarae Member Posts: 163
    edited December 2014

    Hello Jmo06 - I am on Herceptin/Perjeta indefinitely until it stops working. I have a constant runny nose. Which as I understand a normal side effect of Herceptin. I also have stiff joints and pain in my upper back and shoulders which may be a lagging side effect of the Taxotere or a side effect of the Herceptin/Perjeta. I finished Taxotere in June. I wish you and your family all the best - Karen

  • Jmo06
    Jmo06 Member Posts: 159
    edited December 2014

    Thank you Teakie88 mikarae

    was just hard to hear that lifelong injections is our reality =(

    hoping for all to be NED

  • smitty
    smitty Member Posts: 3
    edited December 2014

    I am new and this is my first post. 4th of 6 TCHP treatments tomorrow. No problem with counts, but other side effects are a bit of a problem. Here is my question: I am only having 6 treatments of perjeta, and then Herceptin only for the rest of the year. Also radiation and hormonal meds too. Is this experience similar to anyone else's experience? It seems, in reading others' posts, that many people have more perjeta treatments.

  • linzer
    linzer Member Posts: 164
    edited December 2014

    I had 4 Perjeta treatments and that was it. I think that most who are not metastatic have between 4-6 but I could be wrong. Hope you keep ahead of the SE's and that you are done before you know it. Best, Linda

  • Lrwllms
    Lrwllms Member Posts: 9
    edited December 2014

    Smitty you're more like me. I'm taking TCHP for 6 cycles every three weeks. Then I get the neulasta injection the day afterward. After that, I'll have my surgery and keep herceptin going to complete the year, every three weeks. Then radiation for 6.5 weeks. I won't start until Jan. 9th. I get my port in on the 7th. What side effects are you experiencing

  • Moderators
    Moderators Member Posts: 25,912
    edited December 2014

    smitty, Welcome to the BCO community. We are glad that you reached out here. Keep posting as there are wonderful members who are informed and supportive. The Mods

  • smitty
    smitty Member Posts: 3
    edited December 2014

    I have had some pretty extreme joint pain which results in insomnia. I also have had the big D for about 2 months now. The doc is trying to work with these SE, but some people just have them regardless what is done. Taking IV fluids as needed. I think, though, that I am blessed because my SE effects are not resulting in treatment being delayed. Doc also expects these meds to work completely. He is very upbeat and after an appointment I always feel positive about things. I also have a great family and community and church who help as needed.

  • smitty
    smitty Member Posts: 3
    edited December 2014

    Thank you for the replies. I am glad to hear there are others with same treatment at same stage. I trust my doc but it is good to hear what others are saying too.

  • LakesideWLabs
    LakesideWLabs Member Posts: 29
    edited January 2015

    I start neoadjuvant THP therapy on Thursday Jan 8th. Were any of you given Benadryl or steroid "pretreatments" to take a few days before your first infusion? Also how long does initial infusion take? And are you able to drive yourself home? Apologies for peppering you with questions... anxiety is setting in big time! Thanks for sharing your experiences.

  • CassieCat
    CassieCat Member Posts: 1,257
    edited January 2015

    smitty, I did what you're doing. I finished 6 TCHP on Dec. 15th and will continue Herceptin for a year. I'm tentatively scheduled for an MX this coming Friday, so we're holding off on the first Herceptin-only infusion until the 23rd.

    Lakeside, good luck with your first infusion. They ran things slower for me, so my first infusion day (TCHP) took a good 6 hours or so from start to finish. I took oral steroids starting the night before and the morning of, and then they gave me Aloxi (anti-emetic), Benadryl and more steroids in my IV before they started the chemo. I probably could have driven myself home every time, but I was always glad I didn't have to. It was more mental than physical, though.

  • LakesideWLabs
    LakesideWLabs Member Posts: 29
    edited January 2015

    cassiecat, thanks for the info. Looking forward to getting this chemo show on the road...

  • CassieCat
    CassieCat Member Posts: 1,257
    edited January 2015

    Lakeside, you're welcome. Chemo isn't fun, but you do get through it. I'm already three weeks PFC, and I can clearly remember feeling like I would never finish while in the midst of it. But you push through. Stay as well hydrated as you can. That is very helpful.

  • Jmo06
    Jmo06 Member Posts: 159
    edited January 2015

    LakesideWLabs mom was given steroid takes 3 days

  • LakesideWLabs
    LakesideWLabs Member Posts: 29
    edited January 2015

    thanks ladies! I made it thru THP on 1/8 and then just taxol on 1/15. I have to say that bowels are the biggest issue... I have found myself having more discussion about bowel movements in the past few weeks than ever in my life. My dr asked me this week how that aspect was going if any better and I broke out into hysterical laughter ... slap your knee, snorting, pee your pants, crazy laughter. I even had her laughing uncontrollably! I don't know why but it just struck me funny that this is my #1 conversation.

    Here's to all of my THP sisters... Wishing you more good days than bad and fewer conversations about BMs! Haha


  • CassieCat
    CassieCat Member Posts: 1,257
    edited January 2015

    Lakeside, isn't it amazing what we have to (and then want to) talk about? Glad things are going alright for you so far. Hang in there!

  • Shelly0203
    Shelly0203 Member Posts: 1
    edited June 2015

    Hi. So appreciate sharing the exerience. I finished my first treatment (TCHp) a little over a week ago. Seemed ok 2 to 3days after then the side effects kicked in and still there day 8. Words of wisdom in prep for round 2?

  • Moderators
    Moderators Member Posts: 25,912
    edited June 2015

    Welcome Shelly! You're sure to get lots of support here!

    --The Mods

  • jcfree
    jcfree Member Posts: 105
    edited June 2015

    Shelly 0203, sounds like you got through your first treatment ok. The pre-meds you get before the chemo help to hold off SE's for a couple of days. I knew after my first treatment that I can count on feeling good for about 48 hr. after the treatment. The third day after I crashed, all the pre-meds are out of the system and on come the SE's. It took me a week and a half after each treatment before I started feeling better. My treatments were every three weeks, so week and a half felt crappy, the last week and a half felt better every day. Some SE's got better as my treatments went on, except the fatigue, that felt like it got worse as treatments went by. Was just so happy to complete all six rounds of chemo. I hope that for you too. My first treatment was the worst. Hopefully, you will sail through all of yours and have successful outcome.

  • CassieCat
    CassieCat Member Posts: 1,257
    edited June 2015

    Shelly, my experiences were similar to what jcfree said. Usually, though, I was feeling better by week two, and definitely by week 3. My legs got really tired, and as the infusions went on it seems that Big D and Big C were more of a problem more often. But generally, I did keep bouncing back fairly quickly, all things considered. I kept a daily journal of my SEs and what I took for them (meds, ginger, etc) so that I could try to find patterns for future rounds. It helped me prepare better, helped me talk to my MO and gave me some sense of control.

  • peecenluv
    peecenluv Member Posts: 3
    edited July 2015

    still doing ok agnes?

  • scrunchthecat
    scrunchthecat Member Posts: 269
    edited July 2015

    Hi there,

    I am on Taxotere, Herceptin and Perjeta. I completed round 2 of 6 two weeks ago today. I have been doing pretty good with side effects, but yesterday I was at Whole Foods and suddenly felt a weird pain in my right back/shoulder. I have had a kind of low-grade headache for the last couple of days (I finally took a Tylenol this afternoon and it's better). Both bone pain and headaches are listed as possible side effects of Taxotere, but I thought that the side effects would mostly manifest themselves the first week or so after treatment. I am now 14 days out. Thoughts?

    sj

  • mfana
    mfana Member Posts: 14
    edited July 2015

    scrunchthec, It's great that you haven't had much side effects. To me that sounds like neulasta side effects? how long ago was you last shot? Also, are you getting Lupron injections (ovarian suppressor)? that too, causes the bone pain. Mine would start in knee and lower pain, and then spread around, but it was "sudden and weird"

  • agness
    agness Member Posts: 576
    edited August 2015

    I had a Zoladex (similar to Lupron) injection before round 5 that also covered 6. It majorly increased my cognition deficits and greatly increased my muscle pain. Not fun

  • Freygea
    Freygea Member Posts: 300
    edited August 2015

    Scrunch- It could be se's ,could be the neulasta if you get that ,or could be dehydration.


    I am funny I am fine the week after my chemo (same as yours) but then start feeling like crappers around day 8. Try pushing yourself to drink a bit more fluid if you get the headache back and see if that helps. I had a headache for 2 days and nothing helped. I finally held my nose and drank some water down and bada bing headache gone.

  • SFMama
    SFMama Member Posts: 16
    edited December 2015

    I am looking for anyone who had surgery, then chemo (TCHP) and then continued perjeta and perception together for a year? My insurance agreed to adjuvant perjeta only after much lobbying from my doctor. However I want to pursue a full year of Perjeta if it means it will prolong my life, even if insurance doesn't cover it.

    Any perspectives on this?

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