Carboplatin

SCVA
SCVA Member Posts: 11

Curious to know who might be getting carboplatin as part of chemo treatment for triple negative? I am stage iiic and getting 4 dose dense AC (1 more to go) then 4 dose dense Taxol....I am BRCA negative and my Onc doesn't think I should get carbo? Anyone else getting carbo? If so, when is it being given and why did your Onc decide that would be best?

My Onc said it can make platelets drop which could end up delaying treatment...but haven't had problems with my counts yet....

Anyone get carbo post surgery? Pre rads? Would love to hear experiences with carboplatin...thanks...

Comments

  • Redporchlady
    Redporchlady Member Posts: 113
    edited December 2014

    I am getting Carboplatin because my ONC recommended it. I am doing Taxol weekly for 12 weeks and he is adding the Carboplatin every three weeks. I did AC/CY in October and November. My ONC feels it will increase my chance of a better pathology report when I have surgery in March with Carboplatin according to studies. My platelets are holding great but he said if we need to we can do a platelet infusion to keep me going. The thought is if I can have a comple pathological response then a better chance of non-recurrence. We agreed. After surgery I will have 12 weeks of radiation

  • SpecialK
    SpecialK Member Posts: 16,486
    edited December 2014

    SCVA - I am not TN, I am TP but did get Carboplatin with Taxotere, and I am thinking you could add the Carboplatin on with your Taxol after your DD AC - I have done some reading about how Carboplatin can benefit TN patients and if you are doing well after your 4 AC it might be worth pressing your MO about it. The reason for my post is that I worked in Transfusion Services when I was diagnosed, so wanted to respond to the comment about platelets.  Virtually all chemotherapeutic agent affects platelets - how have your held up doing AC?  Platelets are the most mercurial and short lived of the blood cells - they can be high one day, down the next.  A platelet transfusion does not contain red cells, only takes about 20 minutes.  For cancer patients the platelets should be single donor and irradiated - should you need an infusion.  Good luck!

  • SCVA
    SCVA Member Posts: 11
    edited December 2014

    Thanks for the response...

    Specialk...doing well under AC just finished third this week and blood work is normal to date.

    Had consult with Hopkins and my Onc and they seem to think there is little benefit to carbo since I am BRCA negative.

    Redporch....So is the carbo administered with the taxol on the third week or in place of taxol? How many doses of Carbo are they giving you? What are the side effects associated with Carbo?

    How has your tumor responded on the AC? Are you BRCA negative? 12 weeks of rads...wow how often during the week will you have to go....mine suggested 6 weeks for 5 days a week.

    Going to Georgetown in January for third opinion on carbo...eveything I read seems to suggest carbo is a good idea


    I really appreciate the information.

  • Redporchlady
    Redporchlady Member Posts: 113
    edited December 2014

    SCVA- The carbo is given with my Taxol so I have had one Taxol/Carbo and then this last Friday I just had Taxol. I have a team of ONC's because at Mayo you have several follow your case but they did give me the option of weekly Taxol or Taxol every two weeks but I was to get 6 doses or 12 doses weekly. Also the Carbo they want me to have 4 doses over my 12 weekly doses of Taxol. We asked what the difference of weekly Taxol vs. double dose and our ONC said that we get a little more advantage with the weekly for the Taxol because over the 12 weeks I would get a little more dosage. The first time I got the combo hit on Thursday I slept all day Saturday and Sunday. One of Carbo's SE's is fatigue and nausea. I also had some nausea but my meds took care of that. I have had some numbness and tingling in my hands and legs but I was getting that even from my last treatment of AC/CY. Carbo SE are decreased white blood cells, red blood cells and platelet counts but my ONC said no worries that if we need to I will have my transfusions and try not to miss any treatments.

    I had an awesome response to the AC and my lumps in my breast and armpits cannot be felt. My last ONC visit all he could feel under my arms was muscle. We won't know the complete response until I have surgery in March but we are hopeful. I tested negative also for BRCA. After surgery I am to have 5 days of rads for 12 weeks. All I was told that they want to be aggressive plus it could be the way I found out about my cancer so they throwing the kitchen sink at me.

    My journey started August 2013 when I found a lump in my right breast. It was not time for my mammogram but my MD said let's schedule it so I had a mammo and ultrasound. Radiologist said it was a cyst and recheck in 6 months. I was back in January 2014 because I found another lump. Same thing.....mammo, ultrasound, just a cyst, let's recheck in 6 months. June 2014 lumps under my right armpit. Did a mammo and ultrasound, just cysts, he said we could aspirate them but they will come back. My MD said I could remove them and they won't come back. I finally decided to have them removed September 10th because they were painful. Surgeon said it would be routine. It was not. They did not remove all the cysts because they found cancer. So they closed me up and my local doctors could not even tell me what I had or where the cancer was coming from. I was in Mayo September 24th for every test we could get to stage it and a port put in. By October 7th I was getting my first chemo.

    Good luck with everything and I would ask for Carbo. I want to do everything I can the first go around because of it being TN!

  • posij3
    posij3 Member Posts: 10
    edited December 2014

    I had TNBC in 2007, stage 1, grade 3 so they recommended 4 rounds of AC, then 4 rounds of Taxol. Then 45 days of radiation. On my 5th day of recuperation after my 4th round of AC (June 07), was watching Today show. Meredith Viera reported that ASCO (Amer Society of Clinical Oncologists) had just wrapped up their annual conference. New study out from UCLA or Stanford stated that for early stage breast cancer patients, the Anthramyacide class of drugs (AC) only work in 8% of the patients.

    Not trying to discourage you but look into that study. The scientist who developed Herception is supposedly the one who ran the study. Highly respected. The point is that with TNBC, they tend to experiment a tad more because it's not as common and they don't know exactly what to do. I'm 7 years out, feel very good so don't worry, your day is coming. Just be sure and take care of you with good foods, light exercise and some you time, reading, relaxing whenever you can.

    I didn't have that luxury as a single parent with two young boys and a job that required a lot of time. Just take the time you need for you.

    God Bless and soldier on~just asking the right questions helped me to feel better and empowered. Hope this helps~

  • Moderators
    Moderators Member Posts: 25,912
    edited December 2014

    posij3, welcome to BCO and thank you for sharing all the information. So glad to hear that you are 7 years out! Bravo! Thanks for sharing with us!

  • SCVA
    SCVA Member Posts: 11
    edited January 2015

    here is an update....I tested positive for a PALB2 mutation...so my onc switched me to weekly taxol with weekly carbo...seems to be to be much more tolerable than the one dose dense taxol I had...I had terrible bone pain for 4 days on that taxol.....this lower dose still had bone pain but shorter duration and less intensity...so my treatments will end up as follows:]

    dose dense ac biweekly x 4

    dose densr taxol x 1

    10 weekly taxol and carbo....I just finished number 2....8 more to go...I'll finish March 24th....

    hope to have surgery by mid April.

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