Onco score 7,Genetic reoccurence increased by 30%, please help

Let us know what you find out.  My understanding is that certain NBN mutations increase your risk of developing breast cancer (which you already have).  I don't know how they use that information to calculate your risk of recurrence though.  From the info I found (copied below), NBN mutations interfere with DNA repair and the immune system, so I would think radiation wouldn't be a good idea and chemo - unless clearly indicated - would also be out.  The good news is that the molecular profile of your tumor as measured by OncotypeDX shows a very low risk of distant recurrence - but of course that doesn't take into account the NBN.  I hope your oncologist can shed some light.  I would consider asking for a referral to a geneticist (MD - not a genetic counselor) that has some experience with managing patients with NBN mutations. 

breast cancer - associated with the NBN gene

Recent studies suggest that certain inherited changes in the NBN
gene may be associated with an increased risk of developing breast
cancer. The c.657_661del5 mutation that is commonly seen in people with
Nijmegen breakage syndrome is thought to increase the risk of breast
cancer in people who have one copy of the mutation in each cell. It is
estimated that people who have the c.657_661del5 mutation have a
threefold increased risk of developing breast cancer compared to
individuals who do not have this mutation. A few other mutations in the NBN gene have also been associated with an increased risk of developing breast cancer. Researchers believe that the NBN
gene mutations associated with breast cancer prevent nibrin from
responding effectively to DNA damage. As defects accumulate in DNA, they
can trigger cells to grow and divide uncontrollably, causing cancer.

other cancers - associated with the NBN gene

Inherited mutations in the NBN gene
have also been associated with several other types of cancer. Studies in
Eastern European populations reported that people with mutations in one
copy of the NBN gene in each cell may
be more likely to develop prostate cancer, ovarian cancer, an aggressive
form of skin cancer (melanoma), or cancer of blood-forming cells
(leukemia) than people who do not carry NBN mutations. Cells with a mutation in one copy of the NBN
gene do not repair DNA as effectively as cells without these mutations.
It is thought that DNA damage accumulates over time, which can trigger
cells to grow and divide uncontrollably and increase the risk of
developing cancer.

From

http://ghr.nlm.nih.gov/gene/NBN

Nan - do you have a genetic counselor?  If not, you should ask for a referral to one.  He/she can explain why you had the tests you did and if further testing is indicated.  I was tested for BRCA including BART with Myriad, then the Broca panel out of the University of Washington and no mutations were found.  I worked with a genetic counselor from the beginning - she and the geneticist spent a lot of time with me to figure out the correct path.