PAX2, AIB-1 in Her2+ & ER+ Tamoxifen Resistance

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1rarebird
1rarebird Member Posts: 91
edited August 2014 in HER2+ (Positive) Breast Cancer

I have been trying to learn how Tamoxifen resistance often occurs in Her2+ and ER+ patients.

I have learned so far is that researchers apparently find that Tamoxifen works by down regulating (turning off) the Her2-ErbB2 gene via the estrogen receptor ( ER)  signaling pathway.  This process requires sufficient levels of the PAX2 protein to be present. If PAX2 is low, the Her2-ErbB2 gene remains activated (turned on) and the growth of the breast cancer cell continues unimpeded. And even if the patient has high levels of PAX2, resistance to Tamoxifen can still occur if another protein, AIB-1, is high because of its interference with PAX2.

So my questions are: 

1.) are doctors now testing in clinic for the PAX2 and AIB-1 protein levels; and,

2.) are there any drugs, supplements, foods, etc., that can help achieve the best levels of PAX2 and AIB-1 for those on Tamoxifen and who are Her2+ / Er+ ?

bird

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  • AlaskaAngel
    AlaskaAngel Member Posts: 1,836
    edited August 2014

    bird, I know this post is 4 years old, but my dx was similar to yours except I was diagnosed in 2002.  and I quit tamoxifen after doing 1 year at full dose and 3/4 year at half-dose. I've never recurred, and chose not to take an AI instead. I also have never had trastuzumab or any other drug for cancer after completing CAFx6 and rads. Your question was the same one I have had about tamoxifen resistance. If you happen by, I'd be interested to know whether you ever found the answer to the question.

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