Cancer Cure On The Horizon?

I think Immunotherapy is the answer , thanks,

S

It sounds too good to be true.  I wonder if the big pharma giants will respond or allow this drug to become available to patients.  They are all about making HUGE profits off the sale of oncology treatments.  IMO they are not about ethics or compassion, and no FDA, Approval agency, Oncology society, or country has forced them to make that their priority - saving lives.....

http://www.hopkinsmedicine.org/news/media/releases/cells_recycling_center_implicated_in_division_decisions 

Here's the Science Daily report:

Leukemia drug found to stimulate immunity against many cancer types Date: June 11, 2014

Music Lover, here's another report from University College London (UCL) who did the research along with other institutes.  They only name it as "p110δ inhibitors". (p110 Delta.)

"The p110δ enzyme is a member of the PI3-kinase family, and is sometimes
called PI3Kδ.  p110δ and the other PI3Ks are hot drug targets for the
pharmaceutical industry as they are implicated in many cancers and are readily
druggable."

And here's the best quote, from the end of the piece:

Professor Nic Jones, Cancer Research UK’s chief scientist and director of
the Manchester Cancer Research Centre, said: “Treatments that train the immune
system to recognise and kill cancer cells are showing huge promise in several
types of cancer. This new finding, although only at an early stage, offers the
potential to develop more treatments that can do this in many more cancers,
including ones that have real need for more effective treatments such as
pancreatic cancer.

“If the findings hold true in cancer patients this could make a big
difference to many of them. The good news is that because the drugs used in
this study are already being used in the clinic, we could see rapid translation
of this research into patient benefit.”

Leukaemia drug found to stimulate immunity against many cancer types

Both the above drugs and anti-cd47 therapy aim to help our immune system to recognise cancer as a target to be attacked but appear to use different pathways to do it.  The more different pathways studied, the better, as one may work better than others or they may work better on different cancers.

There are Wikipedia pages and many other web pages about both anti-cd47 and p110δ inhibitors but none are easy to understand.This Wikipedia page on PI3-Kinase Inhibitors makes no mention of cd47 in a page search so I assume they are different.

Edited to say I am now following the People for cd47 Facebook page, thanks for that information.

Hi JohnS,

I just saw your post here and I agree that the facebook page does not clarify things.  Here is another thread that I started in which I included several posts to explain anti-CD47.  I just emailed Stanford's communications officer for the latest info about this new drug and he said,

"The phase I safety trial will start with just one patient in order to lower the risk of testing this very new therapy, but more patients will be added slowly in the following weeks and months as safety is demonstrated. Ultimately the trial will include about the typical number of patients involved in FDA phase I safety trials. 

From what I have heard, the trial will probably start sometime in the next month. Because the trial is starting slowly, the initial patients will be from among the pool of current Stanford cancer patients. "

I believe they may be starting with children, I forgot to ask him about that.  This drug is a long shot for me but it has gotten some very good press and I don't have many other baskets to put my eggs in. 

 Honestly, I hated this disease before I was diagnosed (who likes it?), I saw too many women die of it no matter when they were diagnosed.  If this anti-CD47 works the way the researchers would like it to, so many people will be saved (dx with various cancers). Say prayers for all of them, I do.

I hope I helped...

I do think that it may be two separate things because I did some of my own research and Joy has too (thanks Joy).  It will be interesting to see what Mr. Barron says about anti-CD47 if he responds.  Thank you again Deanna.

I think that they have recruited everyone for the phase I part of the clinical trial and you needed to be a Stanford patient and I believe a patient who is out of options.  They should be finishing this phase by Jan 2016. If all goes well they will have a phase II,  I continue to pray for this one to work.  If you get any other info on it please post it here. Thank you!