Any very high Ki67 score long-term survivors?

Anonymous
Anonymous Member Posts: 1,376
edited October 2014 in High Risk of Recurrence or Second Breast Cancer
Any very high Ki67 score long-term survivors?
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  • Anonymous
    Anonymous Member Posts: 1,376
    edited June 2014

    Mine was NINETY. I know Her2+ cancer is more aggressive and cancer in young women is more aggressive (I fall into both categories) but I've never heard of anyone else having such a high score. It gives me the creeps thinking that before I started treatment (and hopefully that halted things effectively!) these cells were replicating at 90 percent. 

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  • Nettie1964
    Nettie1964 Member Posts: 759
    edited June 2014

    Can't help on the long term part, but mine was 97.  Can you say freaked out. But I've also been told that aggressive cells usually respond to chemo.

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited June 2014

    Nettie - thank you. Yes that is true about fast-growing cells responding best to treatment and I hope that it's true for me!

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  • lintrollerderby
    lintrollerderby Member Posts: 483
    edited June 2014

    Mine was 76%. I am 3 years out and was diagnosed at age 34. I have seen a few women with scores of 99% and 100%. It happens with Triple Negative and HER2+ breast cancer. I was worried when I saw my score in my pathology report, but my medical oncologist said that many MOs don't use the score and lots of pathologists don't even run Ki-67 results because they don't really give much in terms of prognostic indications. 

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited June 2014

    That's a relief to know lintrollerderby. I've been feeling doomed because of it.

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  • Lily55
    Lily55 Member Posts: 3,534
    edited June 2014

    I had two separate pathologies done - there was a 50% difference in KI-67 between the two pathologies which i put down to which actual bit of tissue or cells they looked at........

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  • Summer1234
    Summer1234 Member Posts: 14
    edited August 2014

    Hi I'm 35 and my KI-67 was 75%               I am ER+ PR- HER2 - so not sure why mine was so high 

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2014

    Summer, probably because you are young. Young women have more aggressive cancers in general.

    I'm going to ask if my ki67 was retested after my mast. I think what Lily says is interesting and I wonder if the 90% figure actually is accurate. I've never heard of another triple positive with such a high score - just hormone negatives.

    Or maybe I'm just trying to talk myself off the ledge.

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  • Leighku
    Leighku Member Posts: 26
    edited October 2014

    My original biopsies for 2 tumors were 81 and 87%.  After mastectomy, they were tested again and came back 35 and 65%.  My doctor, who is a top doc at university hospital here says he does not take much stock in ki67 because they vary so much when retested.  He said he considered it and the grade 3 when determining chemo was need but that was all.  He said fast growing cancer makes it an easy target for chemo....so if I did chemo it is actually a good thing.  Lower ki67 and grades do not respond well to chemo.  As back up...I'm highly ER & PR+ but he thought chemo would kick my cancers butt.  Even with these terrible pathology numbers and stage 2 (which I googled and cried many times over...and wrote myself off as a goner) he gave me great survival prognosis that is right there with the lower stage/grade/ki67 ladies.  I just had to do the whole kit and kaboodle (surgery, chemo and hormone treatment).  Just finished fourth and final round of chemo last Friday!

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  • rita22
    rita22 Member Posts: 14
    edited October 2014


    my KI67 score is 76%.  I did not have lymph nodes involved.  I am a stage IIA.  I had a lumpectomy two weeks ago but now I am worried that I should have had a mastectomy.   Any thoughts?

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  • geewhiz
    geewhiz Member Posts: 1,439
    edited October 2014

    Mine was absurd...like 87% or something? Odd that it was a Grade 2

    Still standing, 5 years out

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  • Meow13
    Meow13 Member Posts: 4,859
    edited October 2014


    My oncodx was 34 don't know my KI67 but I bet it was high. I too am still standing 3 years out.

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