4 new genes confirmed to increase familial breast cancer risk

cp418
cp418 Member Posts: 7,079
edited July 2014 in High Risk for Breast Cancer


http://medicalxpress.com/news/2014-06-genes-familial-breast-cancer.html

Four new genes confirmed to increase familial breast cancer risk

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  • leaf
    leaf Member Posts: 8,188
    edited June 2014

    Thank you, cp.  I'm so glad they are discovering more, bit by bit.

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  • april485
    april485 Member Posts: 3,257
    edited June 2014

    Thanks for posting this...the link led me to some excellent reading besides this great article.

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  • farmerlucy
    farmerlucy Member Posts: 3,985
    edited June 2014

    Thanks CP  - I think I'll go be an ostrich now and bury my head. Not so sure I want to know. But knowledge is power for DD's sake.

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  • Moonflwr912
    Moonflwr912 Member Posts: 6,856
    edited June 2014

    I was BRCA negative. But with my family history,  the Genetic counselor told me it wasn't genetic but Familial - which just means they haven't found the gene yet. So now they have 4 more genes identified. Progress. Slow but some progress. For my 2 daughter's I am pleased. 

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  • cider8
    cider8 Member Posts: 832
    edited June 2014

    my geneticist thought my cancer might be familial.  My girls are 10 & 13 now.  My niece's grandma passed from ovarian cancer, so she could have something from both sides.  All BRCA neg.  I will find out more as I can.

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  • wallycat
    wallycat Member Posts: 3,227
    edited June 2014

    Now if they could figure out what to do about it.

    ovarian and breast removal are so drastic, but intestinal?  who's gonna remove their colons?

    sorry to be a downer but just frustrating that they may tell you you will get it but then you have to be a sitting duck.

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  • lekker
    lekker Member Posts: 594
    edited June 2014

    I've posted a lot about the Broca panel out of the University of Washington because I think that it's the most extensive test for the money (downside is it takes 3 months for results).  It tests over 40 genes - including three of the four "new" ones mentioned in the article.

    http://web.labmed.washington.edu/tests/genetics/BROCA

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  • lekker
    lekker Member Posts: 594
    edited June 2014

    Wallycat - actually some people do have their colon removed prophylactically.  Carriers of a mutation for Familial  Adenomatous Polyposis for example.  People with lower penetrance mutations, like Lynch Syndrome, might also do it but colonoscopies are actually good at finding lesions before they become invasive cancer so a frequent screening schedule is often implemented.  If you have a mutation in CDH1, you might consider having your stomach removed to avoid diffuse gastric cancer (and possibly a BMX to lower risk of developing ILC).  And yes, if you have a BRCA mutation, you might consider BMX and oophorectomy.  In place of BMX, increased screening is offered, but as many of us know, invasive cancers can develop without being visible on imaging and/or in between images.  And there's no screening for ovarian cancer.  Yes, it's barbaric.

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  • farmerlucy
    farmerlucy Member Posts: 3,985
    edited June 2014

    My husband had half of his colon removed for non-familial polyposis. Then he started on Celebrex which was discovered to reduce colon polyps. This was seven years ago. He is perfectly fine today and hasn't had a single polyp in three years (He'd had hundreds before.)  Yeah - He's got a hemi in there!

    Guess I'll check out the Broca panel.

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  • Enerva
    Enerva Member Posts: 3,162
    edited July 2014

    Thanks for this info.

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  • have2laugh
    have2laugh Member Posts: 132
    edited July 2014

    Thank you for posting-perfect timing for me. I received a phone call out of the blue from genetics nurse from our regional cancer center this week prompting me to consider a different genetics panel. My insurance would only cover BRCA 1 and 2 panel- done in February and negative -but she has since had luck with my insurance carrier approving another labs more involved testing including amongst other Tp53, Chek2 etc. This article gives me a few more to consider and I will bring with me when I go in 8/4 for this testing. Fingers crossed my insurance goes for it! I am waiting to hear results of breast MRI done yesterday on opposite breast for suspicious area follow up and need to schedule colonoscopy due to three sisters with tubular adenomas. I feel confident all will be ok and screening is important but I jokingly told my sister to stop looking for things as it seems to lead to all of us having additional tests!  I may have said this before in another post so sorry if repeated history. All involved in my care certain some genetic link just not BRCA-very strong history in family of cancers and three of five sisters-my multifocal DCIS at 43, others 44 and 45 w/ IDC (both BRCA negative). May not change treatment or follow up for us but can help us guide our daughters and help them decrease risks by lifestyle, birth control options, breastfeeding, etc.My surgeon is certain there will be treatments available for my daughters resulting from genetic studies and I do think we will see that day sooner rather than later. I only have daughters but I should reiterate what ladies above mentioned- these genetic mutations may affect males so have implications for both sexes. Thanks for the info!

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