Anyone on Taxotere, Perjeta and Herceptin

I just started taxotere, perjeta, herceptin and carobplatin this past Wednesday. 

My wife is 26 and on TCHP (Taxotere, Carboplatin, Herceptin, & Perjeta) 5/6. Her side effects have actually been well tolerable (relatively speaking). Hardly any nausea, in fact her appetite has been spectacular and unchanged since chemo began. She takes prescribed steroids before chemo infusions to help with this and it appears to have worked well. Her hair fell out a little after her second round of chemo (probably about 4 weeks after treatment began). She still has her eyebrows (thinned out a little but definitely still there) and her eye lashes look unchanged. The first week after any given infusion is the most difficult. During that first week she is generally more tired and has less energy to do things. She is rarely in pain though. Furthermore, she has worked full-time during this whole process and is fine, although she can be quite tired the first week back (understandably). Most likely her worst side effect has been stomach/gastrointestinal issues, such as diarrhea and constipation - which has always seemed to be her friend throughout chemo, unfortunately.

But honestly, it hasn't been terrible (mind you this is coming from her observing and helping husband, though I believe she would agree with me for the most part). The very best part of neoadjuvant chemo has to be that her 2.7 lump (very tangible at first) totally melted within 1-2 weeks. By the second infusion, it had disappeared completely. This cocktail works amazing for Her2+ ladies and Perjeta is cutting edge. Please keep in mind, however, this was our experience and your's could be different as all our bodies are different and react to things differently.

If you have any other questions in regards to what to expect, feel free to ask! When you're married to someone with breast cancer, it almost feels like you have it yourself. Not to mention I'm the zealous researcher in the family (she's happy to know enough to make informed choices - which works great for her).

I'm on TCH and Perjeta too.  I have completed 4/6 infusions so far.

Its been 9 days since my first treatment and although I am still suffering through severe abdominal pains I am so happy to say I cant even feel my tumor anymore!  I cant believe it has shrunk so much from one treatment. My energy is finally coming back.  Not looking forward to the next 5 treatments though!

I just had my first treatment of taxotere, herceptin and perjeta on Tuesday.  Had the neulasta shot yesterday and I'm thankful to say I'm feeling pretty well.  I'm praying this continues!!  Five more to go, then surgery and radiation to follow.  Glad for all the testing to be finished and to finally get started on getting rid of it!!

I go for round 5 of TCH+P tomorrow, and it's been kicking my butt. But it's been kicking the cancer's butt too, so that's okay. I'm stage 4 with lung and bone mets. Just had a PET scan last week, and it showed dramatic improvement since my diagnosis in January -- near complete resolution of the lung infiltrates, bone spots are "stable" on the CT part of the scan (MO said that was good -- apparently it's hard to get those to go away) , and on the PET part of the scan, they weren't lighting up anymore. NOTHING lit up at all!!!  Side effects from this cocktail are rough, but it's working like magic on me. I hope all of you see awesome results too! :-)

Thanks for the suggestion -- that's Kadcyla, isn't it? I've heard it mentioned but don't know much about it. I assume that will be in my MO's bag of tricks down the road.

I've been curious about that, too. I'm getting TCHP. Since I had TCH 4 years ago, I didn't think much about just adding Perjeta this time. But seeing some people get only THP has made me wonder. I go for my last round of TCHP this Friday and will ask about it if I get a chance. (I don't always get to see the doctor on chemo day.)

Had an MRI today.  I've had two cycles of THP chemo and there hasn't been any change.  I was really hoping to see some reduction.  Looks like the onc will probably be adding carboplatin to the next round.  So far I've tolerated the side effects well but what can I expect from adding this new drug?

I did 3 treatments with TCHP and today had my 4th with just THP.  We dropped the carbo b/c I am experiencing hearing loss.  Apparently that NEVER happens with breast cancer patients.  I'm that one in a million I guess.  I was on schedule to do 6 TCHP treatments and then surgery but since we dropped the carbo I am having surgery in 2-3 weeks and then more chemo.  She doesn't even know which cocktail to use post surgery since I'm off the treatment plan now.  We'll just have to wing it.  I have many of the same SE's - the first week is dreadful.  I get sore from head to toe (warm baths in epsom salts help enormously), depression, fatigue and then the diarrhea hits.  It's 10-14 days of diarrhea due to the taxotere and perjeta but it's more manageable each cycle.  I started acupuncture after my second treatment and it's helped alot both with the diarrhea and my low red counts.  Last go around I was able to go back to work during Thursday of the second week.  It had been the third week each time before.  I had an ultrasound and mammogram last friday and my tumor was gone!  So that's good news at least!  

Has anyone had to deal with hot flashes on this cocktail? I'm not taking any hormone therapy, because my tumor isn't hormone receptor positive. No major sweats, just hot flashes pretty frequently. It's horrible on top of feeling crappy since my treatment on Friday.  I just had treatment 5 of 6, then on to surgery this summer. I can't wait to have this all behind me!

Yes on the hot flashes for me too.  They don't cause me to sweat but it's like a fire gets lit all over - it's crazy!   

yay for your wife!! How is she feeling now? 

I just had my 2nd round. So far the rash is stayed away. My eyes and nose are dropping like crazy though. Much worse then last time. My eyes actually sting and are very red. Hoping for no diarrhea! I'm getting my Neulesta shot today and going for a bag of fluids tomorrow. I've found that having those extra fluids really helps. I learned this little trick from my many trips to the ER.