Vitamin D

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Momine
Momine Member Posts: 7,859

I just saw this article about a new vitamin D and BC study. Thought it might be of interest.

Note that they are measuring  25-hydroxyvitamin D, which is measured in ng/ml. You can find conversion tables online to other ways of measuring D.

http://zeenews.india.com/news/health/health-news/vitamin-d-boosts-breast-cancer-patient-survival_27023.html

Comments

  • Lojo
    Lojo Member Posts: 303
    edited March 2014

    Interesting. From some of the other things I've read, they're still not sure which way the causality goes - if low Vitamin D triggers the cancer, or whether the cancer itself cause low Vitamin D levels  -it's not a trivial issue - since it's unclear whether supplementing with D will actually increase levels of D in people with BC. 

    I don't know what mine were at diagnosis (or now). I had been taking 1000 iu prior to diagnosis for years. I guess I feel like it's probably not hurting me, and maybe it's helping. My doc didn't want me taking any higher than that during radiation.

  • cp418
    cp418 Member Posts: 7,079
    edited March 2014

    http://health.ucsd.edu/news/releases/Pages/2014-03-06-vitamin-D-and-breast-cancer-survival.aspx

    Vitamin D Increases Breast Cancer Patient
    Survival 

     oops - looks like the same article -- very popular in the news! 




  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    Lojo, I hear you. That is my issue with it as well. All the same, I am glad some research was done on it. Maybe we can hope for more of the same.

  • Heidihill
    Heidihill Member Posts: 5,476
    edited March 2014

    I hit a low of 18 nmol/l five years ago. I don't really know what it was at diagnosis. Now I am up to 127! So supplementation at the doctor's office worked for me. That's about 7 (!!) and 50 in ng/ml.  

  • Holeinone
    Holeinone Member Posts: 2,478
    edited March 2014

    Momine & cp418,

    Thanks for the info, as far as I know, I have never had this checked, but last month a oncology nurse suggested to the Dr.  to run it. 

  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    My docs were not inclined to check it either. I finally insisted after I had finished treatment. At that point, mine was 35 (by the same measure as in the article). However, my lab clearly was not used to doing this. They had to send it out, and it took weeks to get the result. The lab otherwise does almost anything and everything overnight.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2014

    Question:  I'm looking at the sheet of my test results and there are, it seems, 2 different measurements.  This is from Dana Farber, so it's the one I TRUST COMPLETELY.  The ones I had done by local doc was "wonky" to say the least, not accurate. What's confusing me, is that when I had Vitamin D tested at local docs,
    the "range" was 30 - 100.

    Vitamin D total ( 250H)

    Unit:ng/ml Reference value--25 HYDROXY D TOTAL ( D2+D3) Optimum levels in the healthy population are 20-50, patients with bone disease may benefit from higher levels within this range.

    AND THEN:

    Vitamin D ( 1,25 DOH)  Reference range: 18 to 78 

  • jmg58
    jmg58 Member Posts: 185
    edited March 2014

    Mine's been at 20 even with taking 1000 a day for the last two years.  I'm almost at chemo now so MO has had me take 50,000 IU for the last four weeks, once a week.  I will be curious to see where I'm at now!

  • Moonflwr912
    Moonflwr912 Member Posts: 6,856
    edited March 2014

    Mine was 14 about 2 months  before dx. I was taking 10,000 a day to bring it up to 30. I now take 5,000 a day. 

  • peacestrength
    peacestrength Member Posts: 690
    edited March 2014

    Good article, Momine - mine was 30 and now 58.  I take 6000 IU daily in liquid form beneath tongue.

  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    Sunflowers, there are at least 2 different ways to measure vit. D. The range of 18-78 and the ng/ml is for 25-hydroxyvitamin D or "1,25 DOH" as they have it on your test sheet. That is the same measurement used in the article.

  • LaurenN
    LaurenN Member Posts: 49
    edited March 2014

    Vitamin D


    Aug 23, 2013 06:57PM LaurenN wrote:

    Can high levels of vitamin D help to prevent breast cancer?l

    The Globe and Mail
    Published Monday, Mar. 18 2013, 2:48 PM EDT
    Could a drop in vitamin D levels circulating in a woman’s bloodstream predispose her to breast cancer? Some U.S. researchers believe the answer to this question can be found in blood samples collected and stored by the American military.
    In total, nine million vials of blood were drawn from members of the U.S. armed forces from 2002 to 2008 as part of a routine monitoring program for infectious diseases. The samples were usually collected every two years.

    Link to this article and numerous related articles:
    http://www.theglobeandmail.com/life/health-and-fit...

    Aug 7, 2013 11:44PM LaurenN wrote:

    Momcat1962....re Vitamin D information

    Hopkins Breast Centre, Baltimore, MD
    Ask Your PCP to Test Your Vitamin D Level - Here's Why
    By Lillie Shockney, R.N., M.A.S.
    Mar 17, 2013
    Blood analysis studies of 1,200 healthy women found that those women whose serum vitamin D levels were low during the three-month period just before their diagnosis with breast cancer had approximately three times the risk of breast cancer as women in the highest vitamin D group. These findings were published in the journal Cancer Causes and Control.
    Several previous studies have shown that low serum levels of vitamin D are associated with a higher risk of pre-menopausal breast cancer. This report stated that while the mechanisms by which vitamin D could prevent breast cancer are not fully understood, this research suggests that the association with low vitamin D in the blood is strongest late in the development of the cancer—that is, just before the cancer is detected and diagnosed.
    Scientists have hypothesized that this time period (late in a tumor’s development) is likely to be the point at which the tumor may be most actively recruiting the blood vessels required for tumor growth. Based on this new information, further investigation is now needed on how vitamin D reduces the incidence of pre-menopausal breast cancer, particularly during the late phases of its development. Such research will be taking place.
    The new study drew upon nine million blood-serum specimens frozen by the Department of Defense Serum Repository for routine disease surveillance. The researchers thawed and analyzed pre-diagnostic samples of serum from 1,200 women whose blood was drawn in the same time frame—from 600 women who later developed breast cancer and 600 women who remained healthy.
    It was estimated that a serum vitamin D level of 50 nanograms per milliliter of blood (ng/ml) is associated with a 50-percent lower risk of breast cancer. While there are some variations in women’s ability to absorb this vitamin, those who consume 4,000 IU per day of vitamin D from food or a supplement will normally reach a serum level of 50 ng/ml.
    The authors’ recommendation for patients/consumers was NOT to rely solely on a pill form of the different forms of vitamin D, such as vitamin D2—better to get this vitamin through sunshine exposure and certain foods rich in vitamin D. There are situations, however, where a woman’s blood level of vitamin D is so low that her doctor will prescribe megadoses in the short term, so as to bring her level up to within the normal range.

    Do Vitamins, Herbs, and OTC Remedies Affect Cancer Treatment?
    By Lillie Shockney, R.N., M.A.S.
    Apr 14, 2013
    It seems that, just because we can buy these products without a prescription, they are considered harmless. But they sometimes can in fact harm you, especially if you are embarking on breast-cancer treatment.
    Here are some examples:
    Taking vitamin E prior to a core breast biopsy, or any breast surgical procedure, can result in excessive bleeding, even hemorrhaging, because this vitamin contains a blood-thinning product substance. So does aspirin.
    Those taking adriamycin, a common breast-cancer chemo drug, should never take vitamin C tablets during the entire time period (months) they are receiving this drug intravenously. Vitamin C will actually undo the benefits of getting the chemo.
    What about herbs?
    We really have no solid, scientifically based, proven research about the effects of any of the herbs, as far as whether or not they are okay to take together with cancer treatments of any kind.
    So before you start taking—or continue to take—any complementary medicines, please inform your doctors. Don't assume that because they are easily available without a prescription that they are fine to take. Don't jeopardize your health in that way.

  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    Lauren, I agree with you. I did not post this in order for people to take a bunch of vitamin D pills. It was really more to let people know that it does give a basis for getting D-levels checked, for example.

  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    Kay, thanks for that list. I eat a lot of mushrooms as well as fatty fish, including raw salmon.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2014

    raw salmon?  cerviche?  or as "sushi"....can't imagine how to prepare it.

    Thanks Momine, so that means my level of 68 is great!

  • exbrnxgrl
    exbrnxgrl Member Posts: 12,424
    edited March 2014

    I had salmon last night too. It's my favorite fish in any form, except over cooked. I rarely eat it in restaurants, except as sushi/sashimi or ceviche as too many places over cook it. Older dd made it for me last night, with quinoa. She marinates it for about 1 hour in soy, ginger and maple syrup and them bakes it for a short time. Warm but still only slightly cooked on the inside, lovely glaze on the outside.

    Caryn

  • juneping
    juneping Member Posts: 1,594
    edited March 2014

    i don't know why when salmon is marinated with soy sauce then sautee, it tastes so much better? anyone care to shed some light?

  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    Sunflowers, raw salmon in sushi. However, if you have a good fishmonger (or a really sharp knife), you can slice pristinely fresh salmon filet into paper-thin slices, marinate with lemon and herbs, salt and pepper in the fridge for an hour or two and then eat. Ceviche in other words and really good.

  • exbrnxgrl
    exbrnxgrl Member Posts: 12,424
    edited March 2014

    june ping,

    No scientific explanation for why fish marinated in soy sauce tastes so good, but in general, fish marinates quickly and picks up the flavor of a marinade very readily. Red meats, on the other hand, require much longer marination periods unless sliced very thin as in carpaccio or minced as in tartare.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2014

    I don't doubt the studies about Vit D but I am confused about one thing. If it were such a big factor, wouldn't you see more breast cancer cases in Northern areas than Southern areas? I mean, wouldn't North Dakota have sky-high rates of breast cancer and Florida very low? Or it is about how we as individuals absorb it? Personally, I was getting a lot of sunshine during the five years prior to my diagnosis. Again, not doubting, just trying to understand all the pieces of the puzzle.

  • Fallleaves
    Fallleaves Member Posts: 806
    edited March 2014

    Bad, that is exactly what you would think. 

    But there are a lot of other variables at play that might muddy the waters. Higher altitude might compensate some for being at a higher latitude. Dietary differences might affect vitamin D levels, and different occupations might lead to different levels of exposure to the sun. Also, calcium intake may affect how well vitamin D is absorbed http://www.ncbi.nlm.nih.gov/pubmed/24594863 And, D is probably only one factor affecting whether or not you get breast cancer. Chemical exposure, diet, sleep patterns, heredity, estrogen levels, etc. could play roles. There is some thought, though, that the higher rate of vitamin D deficiency in African American women may account for their greater levels of early and aggressive breast cancer. 

    http://www.ncbi.nlm.nih.gov/pubmed/24594863

    By the way, I read that you can increase vitamin D levels in mushrooms by putting them in the sun (even dried) http://www.huffingtonpost.com/paul-stamets/mushro...

  • juneping
    juneping Member Posts: 1,594
    edited March 2014

    i thought someone mentioned earlier that her doc was wondering that too and thought it's more of chicken or egg first theory...

    from what my int doc told me and what i've read here, there's def a link between vit D and BC. the majority of us had vit D deficiency when diagnosed. 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2014

    Also, remember we're all wearing MUCH MORE SUNSCREEN, no matter where we live.  There was an article ( can't remember where) about group of women gyns in Southern CA who were finding their women patients were SO LOW in D even tho they were in almost constant sunshine.

  • Fallleaves
    Fallleaves Member Posts: 806
    edited March 2014

    That is totally true about the sunscreen, SunflowersMA. I wonder if I may have done my kids a disservice by being so adamant about their wearing sunscreen all the time. 

    I also saw a study of Hawaiian surfers and skateboarders who spent 15 hours a week in the sun for the three months before the study, and their levels ranged between 11 and 71 ng when tested, so it seems there's a lot of variation even if you are getting a lot of sun.

  • Fallleaves
    Fallleaves Member Posts: 806
    edited March 2014

    Oh, here's more from that paper where I saw the Hawaiian surfer study:

    "The 25(OH)D level achieved with the same oral dose of vitamin D varies widely by individual.23,24 The level of 25(OH)D that results in clinical consequences probably varies with calcium intake, race, age, body fat, and individual genetic factors, all of which may influence calcium homeostasis. Genetic variation represented by polymorphisms of certain genes in the vitamin D metabolic pathway explains some of the interindividual variability of 25(OH)D concentrations, particularly polymorphisms of the enzyme 7-dehydrocholesterol reductase in the skin, cytochrome P450 25-hydroxylase in the liver, and vitamin D–binding protein in the circulation.25 The functional effect of a particular level of 25(OH)D depends on the uptake of 25(OH)D by target cells and the efficiency of 1α-hydroxylation to produce 1,25(OH)2D.

    Vitamin D insufficiency 

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC301263...

  • Momine
    Momine Member Posts: 7,859
    edited March 2014

    Fall, makes sense, and I have wondered about this, given that my dad, his bro and his dad all had rickets as kids, in spite of perfectly good diets. It always nagged me that there might be a genetic inability to use D properly.

  • cp418
    cp418 Member Posts: 7,079
    edited March 2014

    Actually there are some formulations of Vitamin D3 supplement for those individuals who have absorption issues.  If you've already tried other Vitamin D3 supplements and do not see improvement in your lab values a different type of supplement may help.   Bio-D-Mulsion Forte

    http://www.naturalhealthyconcepts.com/bio-d-mulsion-forte.html


  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2014

    Can't remember where I read this, but think AGE may be a factor in ability to absorb Vitamin D too.  I know it is in absorption of B12.  So many variables.  

    Also, know a few women with and without bc, who have had problems with parathyroid gland ( not thyroid, but parathyroid, which I'd never even know of b4 friends told me) which malfunctioning can effect blood levels of Vitamin D.

  • geewhiz
    geewhiz Member Posts: 1,439
    edited March 2014

    I can NEVER get my D levels up. I even sit in the sun during the winter with arms and legs exposed with a heating blanket over my middle. Pathetic. I have assumed a D absorption issue too. I have seen those Forte supplements, excellent brand. I take their BIODIM with cats claw and maitake. I'm going to get some of the D ones ASAP. 

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