Drug to reverse breast cancer spread in development

Options

Comments

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    this is good news, thanks:)

  • MusicLover
    MusicLover Member Posts: 4,225
    edited January 2014

    Sounds good. 

  • leggo
    leggo Member Posts: 3,293
    edited January 2014

    I've been scouring the web for more info on this but haven't found much except for what the above articles are saying and I'm unclear. When the gene was supressed, the mice didn't develop mets? How would they know it wouldn't have without the gene supression?  Or, they already had metastatic disease and it remained stable? Also, could happen without the gene supression. The only thing I didn't see clearly spelled out is that the mice already had metastatic disease, but showed regresssion. If that's the case (and maybe I'm just not seeing it), that would be awesome, but the other two scenarios don't really excite me. If anyone has more info, I'd be really interested in hearing about it. 

  • cp418
    cp418 Member Posts: 7,079
    edited January 2014

    http://www.walesonline.co.uk/news/wales-news/welsh-scientists-developing-treatment-prevent-6594333

    "In recent studies, researchers identified a critical role for a potential cancer causing gene, Bcl3, in metastatic breast cancer.

    In their current research, the team at Cardiff University are looking at ways to suppress this gene through treatment.

    Using computer-aided modeling of how the Bc13 gene works, the group identified a pocket on the surface of the gene that is essential for its function.

    They then identifed a drug that could inhibit the way the gene works.

    When the compound was trialed on mice with metastatic disease, researchers found the drug completely stopped the development of the mice’s metastatic tumours.

    The team are now working to test the compound in clinical trials with the aim of developing a treatment that can block metastatic disease in breast cancer and a variety of tumour types."


     

  • leggo
    leggo Member Posts: 3,293
    edited January 2014

    I did read that. "When the compound was trialed on mice with metastatic disease, researchers found the drug completely stopped the development of the mice’s metastatic tumours". From that, I assumed the mice had metastatic disease and did not progress. My issue is that even us humans with metastatic disease sometimes don't progress for years, so I'm wondering how they know it's due to the gene supression therapy or if that would have been the case anyway. Guess I'll find out as more info becomes available. Thanks for the info cp. Always appreciate your posts.

  • leggo
    leggo Member Posts: 3,293
    edited January 2014

    Guess what I'm hoping for, is somewhere down the road, the term "regression" is used.

  • curveball
    curveball Member Posts: 3,040
    edited January 2014

    I've been trying to find out the name of the drug so I can keep an eye out for clinical trials, but so far I find almost nothing but more links with the exact same wording as the links in the original post. I did find one other article here which says the work was published online on January 26, 2014 in Cancer Research, with a link to the journal, but the most recent articles I saw on the Cancer Research Journal website (in the OnlineFirst section) are dated Jan 23. Very mysterious.

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    There is no drug developed yed. Tiziana pharmaceuticals is trying to develop the drug.

  • mike3121
    mike3121 Member Posts: 410
    edited January 2014

    Wow, this would be an amazing breakthrough. Too many cancer "breakthroughs" don't make the transition from mouse experimentation to human use.

  • curveball
    curveball Member Posts: 3,040
    edited January 2014

    @Srh242, the article says 

    "...the group identified a pocket on the surface of the gene that is essential for its function.
    They then identifed a drug that could inhibit the way the gene works.
    When the compound was trialed on mice with metastatic disease,
    researchers found the drug completely stopped the development of the
    mice’s metastatic tumours.
    The team are now working to test the compound in clinical trials..."

    I want to know the name of what is referred to as "a drug" or "the compound" so I can look for more information and followup stories online. Since this is all happening in the UK, I don't imagine I will be able to participate in any of the clinical trials, but I would like to keep track of the further testing of this drug to see if it works on people as well as it did on the mice.

    @leggo, I'd like to see the word "regression" too. The headlines use the word "reverse" but the text of the story doesn't say spread was reveresed, only that it was halted. 

    Another thing I'd like to know that isn't mentioned in the article...it says this compound completely stopped the development of the metastatic tumors. Do they mean permanently stopped, as long as the mice continued to receive the drug? Or is this another treatment like others, that after a while stops working?

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    @curveball : the article should have said they id a substance and not a drug. For me adrug is something that has a patent.

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014
  • Srh242
    Srh242 Member Posts: 328
    edited January 2014
  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    Probably they are not going to say the name of the compound, so they can sell it to big pharma.

  • curveball
    curveball Member Posts: 3,040
    edited January 2014

    @Srh242, I copied and pasted the URL but got a "page not found" error. What is the link?

  • curveball
    curveball Member Posts: 3,040
    edited January 2014

    I finally found the article in Cancer Research Journal. The title is "Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors", and it was published in January of last year. If you have access to PubMed (often available through public libraries)
    there's a link to the full text of the article. I haven't read it yet
    and don't know if I will understand it when I do.

    I guess what is new and prompted all the press releases this weekend is that Tiziana Pharmaceuticals has agreed to fund clinical trials of the drug that was tested earlier on mice.

  • leggo
    leggo Member Posts: 3,293
    edited January 2014

    I can't even find a phone number for "Tiziana Pharmaceuticals".

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    I found an address but no phone number. It looks like a small company. Weird.

  • leggo
    leggo Member Posts: 3,293
    edited January 2014

    Looks like this pharma company is a tiny off-shoot of an investment company called BioVitas Capital. 

    *A UK–based biotechnology start-up company established by healthcare entrepreneur Gabriele Cerrone though BioVitas Capital Ltd., his international biotech incubator specialised in developing early stage discoveries in the biotech sector.

    http://www.biovitas.com/Welcome_to_BioVitas_Capital___Home.html

    I haven't had any luck getting through. 


  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    I thought it was based in England,

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    Biovitas is in Italy?

  • leggo
    leggo Member Posts: 3,293
    edited January 2014

    For all I know, the pharma arm of this company is in England. There is so much about this that's ambiguous. Hopefully, they'll pick up their phone at some point. 

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014

    Yes, I will ask my english friend to find out.

  • cp418
    cp418 Member Posts: 7,079
    edited January 2014

    I'm going to speculate here that this is not quite a drug yet but still a "research compound".  I agree it only made it into the news because this research got picked up by a biotech/pharma company willing to fund the clinical trials.  Information about the drug compund will be scanty or not available for competitve reasons and because the clinical trials are still pending.....  This is just my guess but hopefully we will see more in the news.

  • Srh242
    Srh242 Member Posts: 328
    edited January 2014
  • ihatesnowihatesnow
    ihatesnowihatesnow Member Posts: 859
    edited January 2014

    hope its a major find ......this disease took my sister last year

  • Dita183426
    Dita183426 Member Posts: 157
    edited February 2014

     http://m.asia.wsj.com/articles/SB1000142405270230...

    Here is an example of how altering genes can work in practice.  The technology is there to implement if it's successful

  • leggo
    leggo Member Posts: 3,293
    edited February 2014

    Apparently, the drug company is even "still in development", so I'm thinking it will be a long time before it sees the light of day. Since the compound and research is "owned" by a bio-tech company working on developing a pharmaceutical company, I'm not feeling to confident. I think money will be the deciding factor. So hope I'm wrong.

  • Srh242
    Srh242 Member Posts: 328
    edited February 2014

Categories