Two tumors, same quadrant, two different types

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LoriBach
LoriBach Member Posts: 130
edited June 2014 in Mixed Type Breast Cancer

Here is my story...I have (or had) two tumors in my right breast with different pathology.

Larger Tumor:  ER-/PR- and HER2+

Smaller Tumor:  ER+/PR+ and HER2-

Any one else have similar situation?

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  • drlauralee
    drlauralee Member Posts: 1
    edited February 2013

    My best friend just got dianosed with two types of breast cancer in her left breast.  I'm learning the lingo, so please excuse me if I don't get this right.  She has a total of 4 tumors in her left breast and so far one is estrogen based, the second one isn't.  She is grade 3.  She hasn't had the other 2 biolpsied yet.  She's going to have a mastectomy on the left side.  There's another tumor in her milk duct on the right side.  She's developed blood clots in her legs.

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  • winterapril
    winterapril Member Posts: 6
    edited March 2013

    Hope more people can share the experience.  I've always thought that primary tumor will all just have the same type...

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  • winterapril
    winterapril Member Posts: 6
    edited March 2013

    Based on this article, apprently, the receptor status test can be erroneous just as any other tests.  From where the sample is extracted to how it's prepared, there are many ways of introducing the error.  It makes sense that if the doctor had sampled the center of the large tumor, it'll be relatively negative because the middle of the tumor is relatively ischemic and will have little reactivity. On top of all that, it's said that the receptor status can change. The whole tumor thing is really a big unknown medically.  Trial and error is probably the only thing that can be done at this point given the current research level.  

    http://www.cap.org/apps/cap.portal?_nfpb=true&cntvwrPtlt_actionOverride=%2Fportlets%2FcontentViewer%2Fshow&_windowLabel=cntvwrPtlt&cntvwrPtlt%7BactionForm.contentReference%7D=cap_today%2Ffeature_stories%2F0108_estrogen.html&_state=maximized&_pageLabel=cntvwr

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  • SoLinda
    SoLinda Member Posts: 120
    edited April 2013

    I had my surgery at a different hospital than my chemo.  At the first hospital, the receptor status was incorrect and said that the cancer wasn't estrogen positive and that it was a good idea to have the tissue tested again.  So, it was tested again at the second hospital and yes, it turned out to be 60% estrogen positive and 80% progesterone positive.  I had invasive ductal carcinoma - 2 cm. tumour in my left breast, and also another area of the same breast which was in situ which had never shown up on any prior scan or biopsy ...  Onc. No. 2 said it certainly was a good thing that I had had the entire breast removed ...  And after my experience with chemo., I have to mention how incredibly important it is to be wary of blood clot signs ...  I had a severe pulmonary embolism only a few days after my last chemo. and am lucky to be alive.  I have been informed that not only can some chemo. drugs influence the development of blood clots, but that cancer patients' blood is in a state of hypercoagulation.  I am taking warfarin because of the pulmonary embolism, and will be taking it at least until I finish taking Arimidex-Anastrozole in another 3 years.  Yippee  Laughing 

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  • marvelher2
    marvelher2 Member Posts: 62
    edited January 2014

    My primary tumor is strongly ER/PR negative (0%) and strongly Her2 positive (3+++).  This is at 11:00 anteriorly on my right breast.  Now, they found a small tumor at 9:00 posteriorly on the completely opposite side of my breast through an MRI guided biopsy and this one is ER+ (90%) PR+(50%) and Her2 negative (only 10% staining).

    Bottom line, they are calling this a completely new and separate cancer occurrence.  With this news, my plans are changing from hoping for a lumpectomy to probably bilateral mastectomy.  Ugghhh!

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