How diet affects our intestinal microbiome/BC risk

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Wow, fascinating paper! Really interesting how what we eat impacts our BC risk AND our bodies' responses to BC through our intestinal microbiomes.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC380067...

Comments

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Yep, it is very interesting. I read something about this when I was first diagnosed, and I have seen enough credible studies to conclude that it is very important to maintain a healthy intestinal system, in general but especially for those of us with BC. 

    I also saw this a while back: http://presse-inserm.fr/en/chemotherapy-when-our-i...

    "Research jointly conducted by investigators at Institut Gustave Roussy, Inserm, Institut Pasteur and INRA (French National Agronomic Research Institute) has led to a rather surprising discovery on the manner in which cancer chemotherapy treatments act more effectively with the help of the intestinal flora (also known as the intestinal microbiota). Indeed, the researchers have just shown that the efficacy of one of the molecules most often used in chemotherapy relies to an extent on its capacity to mobilise certain bacteria from the intestinal flora toward the bloodstream and lymph nodes. Once inside the lymph nodes, these bacteria stimulate fresh immune defences which then enhance the body’s ability to fight the malignant tumour."

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    Yes, Falleaves that was great article. Bravo on finding that gem. Love your fervor and tenacity to find helpful info for all of us. I also liked how the article identified food source lignans and fiber..bananas, whole grains, artichokes, soy beans, fruit and veggies and the percent of reduction of breast cancer, for women had who ate these. Just fascinating. Thanks.  

    Momine, I read that about effects on chemo before too. GLA and sesame lignans supposedly enhances the effect of pacitaxel 9 times...

    http://jacksonsnyder.com/arc/Articles%201/GLA%20Ch...

    http://www.dailymail.co.uk/health/article-367355/E...

    enhances herceptin

    http://www.denvernaturopathic.com/news/EPOHercepti...

    and if you aren't interested in chemo....

    http://www.news-medical.net/news/2005/11/03/14257....

    this article states it suppresses HER2 gene..

    http://www.eurekalert.org/pub_releases/2005-11/nu-...

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    Falleaves, also your article does a good job of explaining why they are now researching the gut flora of women with bc, and comparing to women w/o bc.

  • Heidihill
    Heidihill Member Posts: 5,476
    edited January 2014

    Thanks, Falleaves. Thought this bit on lignans was amazing...62% less bc! Not into rye bread but I'll take sesame seeds, sesame oil and tahini anyday, even everyday.

    A Finnish case-control study also looked at serum levels of enterolactone and their association with breast cancer. Women with the highest dietary intake on lignans (at least two slices of rye bread per day) were in the highest quintile of serum enterolactone (54imagenmol/L) while with the lowest consumption were in the lowest quintile (3imagenmol/L). After eight years of followup, women in the highest quintile of enterolactone had 62% less breast cancer diagnosed compared to the lowest quintile [67].

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Heidi, I love rye bread, but then I am a Dane. Other than herring, I think it is far to say that rye bread is our national food. 

  • abigail48
    abigail48 Member Posts: 1,699
    edited January 2014

    when I gave up all salt in '07, bread was the most difficult & when I tasted it on occasion it was the most utterly delicious

  • cymom
    cymom Member Posts: 54
    edited January 2014

    Interesting.

    A notable connection: the rate of breast cancer in Poland in women who are BRCA+ is almost half of what it is in North America.  This may be due to diet, environment, genetics or some combination of those things. The Polish diet is high in cabbage and roots like potatoes and beets. The deli bread my Polish family ate was a heavy, dark farmer's rye.

    A summary: http://impactinnovation.womensresearch.ca/portfol…

    The actual research: http://www.ncbi.nlm.nih.gov/pubmed/21834074

    Who knows if this means anything, but for anyone interested, Polish rye bread is extremely durable stuff that holds up well in a freezer for months.  It can be found at any Polish deli or even ordered online.  

      

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    Aren't Rueben sandwiches polish?? Would be great to know they are healthy to eat. 

  • cymom
    cymom Member Posts: 54
    edited January 2014

    I think the Reuben is an American innovation (and a good one!) :)

    It's funny, I would not call the Polish diet "healthy" per se -- there is a fair amount of cured pork (e.g., kielbasa), butter and full-fat dairy.   But cabbage appears everywhere, lots of veggies get pickled, and soups made of cabbage, sorel, beets and potatoes are a staple.  And of course, it's not an affluent country.  People tend to cook and eat at home, and when they cook, it's inexpensive stuff (lots of bread and soup, not steak)

  • Fallleaves
    Fallleaves Member Posts: 806
    edited January 2014

    ctnymom, that's an interesting article about Polish women with BRCA1 mutation having less risk of BC than North American women with the mutation. The researcher is doing a study on DIM which is found abundantly in cabbage. I've been taking DIM supplements until recently (stopped because of headaches and other symptoms I associated with low estrogen levels, which I thought might be caused by the DIM). I think now I may just start trying some different coleslaw recipes! I'm also thinking of trying to eat more fermented food (I have "Fermented Foods for Health" in my cart on Amazon). I could also get into eating rye bread (any excuse to eat more bread...;)

  • corky60
    corky60 Member Posts: 726
    edited January 2014

    Fascinating article.  Thank you Fallleaves.

  • SelenaWolf
    SelenaWolf Member Posts: 1,724
    edited January 2014

    I've been reading a lot lately on gut bacteria and how it can affect our health in so many ways.  It's a truly fascinating development.

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    My experience with rye bread is that it usually contains caraway seeds. This prompted me to do a search on caraway seeds.

    http://breastcancerfightnowbydraarontabor.blogspot.com/2011/07/black-caraway-seed-compound-has-breast.html

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Light, I couldn't get the link to work, but Danish rye does not usually have caraway, nor does the very coarse, German stuff sold in supermarkets. Lastly, there is always the option of making it at home.

  • SelenaWolf
    SelenaWolf Member Posts: 1,724
    edited January 2014

    I make my rye bread with about two tablespoons of caraway seed...

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014
  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    I fixed the link above about the caraway.

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Selena, one of my treats when I am in Copenhagen is a pretzel-like thing the bakeries make, but coated in caraway rather than salt:

    image

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Light, thanks for the fixed link. Nigella sativa is also what is known as black sesame, which I love.

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    Momine, just to clarify, the Nigella Sativa seed, is actually black cumin seed,  not black sesame seed. They have many of the same properties however.

    http://www.ehow.com/facts_6239734_difference-black...

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Light, thanks. I realize that "black sesame" is a misnomer, but it is often called that. Nigella sativa are the seeds used on naan and other balkan/middle eastern breads. I only know because I had to go buy some at Christmas, so that my daughter could make a traditional, Greek new year's cake that required them. That is when I learned that they may be useful for us BC people.

  • momoschki
    momoschki Member Posts: 682
    edited January 2014

    This is especially interesting to me, as my integrative onc has me taking black cumin seed oil supplements (among other things.)

  • lightandwind
    lightandwind Member Posts: 754
    edited January 2014

    Momine, yea, I had read that black sesame was a common misnomer for black cumin seed, just wanted to make sure to distinguish between the two. Btw, I haven't had any craving for bread until you started talking about naan and posting pictures of delicious looking bread. I'm going to be searching for some healthy rye bread around here now.

    Momoschki- Here are some studies on Nigella sativa (black cumin seed oil) and its effect on breast cancer.

    http://www.ncbi.nlm.nih.gov/pubmed/12724920

    http://www.ncbi.nlm.nih.gov/pubmed/23317266

    http://cancercompassalternateroute.com/antioxidants-vitamins-and-minerals/nigella-sativa-oil/

  • Momine
    Momine Member Posts: 7,859
    edited January 2014

    Light, my apologies ;) Thing is, in the beginning, I tried to cut out bread completely. I found that, for me, that simply won't work. So I have tried to find compromises. Rye bread is one such. When I have the time/energy, I bake some. When my mom comes down from Denmark, I have her bring some. Her local (eco) bakery makes one that is only rye and chia seeds and it is really good, not crunchy-granola tasting, to me anyway. Most of the time, I stick with the wholegrain bread from our local baker (the article I posted) or I eat barley rusks from Crete, which are really rough but also very tasty. Even so, I eat far less bread than I used to. 

  • cp418
    cp418 Member Posts: 7,079
    edited January 2014

    I find it very hard to find REAL rye breads that are not made as seedless.  (I'm half Polish so rasied on rye bread.)  I've also been avoiding breads for the carbs but LOVE a seeded rye bread!  I wonder how hard these seeds are to digest like flax seeds that need to be ground?  I recall seeing a carrot recipe sprinkled with caraway seeds.  Sounds like another nice seasoning to add to soup or salads maybe besides breads.

    lightandwind -  those links are very interesting and considering the positive findings I wonder why this seed is not mentioned more.  Sounds like some naturalpaths are pursuing it though....

  • momoschki
    momoschki Member Posts: 682
    edited January 2014

    lightandwind,

    Thanks for posting the links.  Reassuring to see that it looks like my dr is on the right track...

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