Have you refused AI or tamoxifan with success? I dont wanna!

I would suggest that you have your onc break down how much of a benefit you will have from the AI. If you decide the benefit is significant, then I would further suggest that you try it for 3 months. If the SEs are too much, you can always stop.

Hi Jenny, I think Momine gave great advice. It's pretty rare for people to get all of the SEs of any drug, and some people don't get any. Are you getting hot flashes now because you are in a normal menopause - I ask because post-menopausal women actually gain bone density from Tamoxifen (one of the 'good' SEs). Really though, you want to consider first how much it lowers your risk. 

If you're Triple Negative ("ER/PR Her2 neg") why is an AI being suggested?  Normally AIs are given to those who are ER pos. not ER neg.

I've been on letrozole (Femara) for almost 4 yrs with basically no SEs that can directly attributed to it.  Of the SE's you mentioned - no heart issues at all, no hot flashes (but then I never had any when I went through natural menopause in 1990), and no weight gain at all.  I had been osteopenia for many years before IBC DX and TX and have progressed in the last 4 yrs to osteoporosis.  I come from a VERY strong family history of osteoporosis so it was only a matter of time til it progressed to osteoporosis anyway.  So could the letrozole/Femara have made it progress faster - yes it's possible but it also possible that in that time frame it would have progressed anyway.  No way to know for sure.  After all I'm 67.

I refused Tam and AI, but as others have said, I won't know until I die of something else. I'm almost three years out and fine so far. I was also unable to complete chemo and did not do rads. My recurrence rate was calculated to be 35%. High yes, but QOL is more important to me. I guess any advice I can give would be as Blessings2011 said, try it and stop it you can't do it. Most importantly, I feel, is to be at peace with your decision.

I am at the tail end of letrozole-- ends in May--- the side effects were manageable.  I had  a slow growing tumor-- I also had an onc who believed that of all the treatments, the AI was the most important for me.  I did it all, chemo, radiation and the AI.  I do not expect this bc to come back and I have been tempted to get off the AI, but I was able to manage the side effects.  I think trying it out is a good idea, but know that the first 6 months (like any drug) can be a challenge (or maybe not).  Takes the body some time to get used to it.  

Best of luck.  it is a hard decision, but it is yours. 

My Bad!  I didn't check her Profile - just went off the PO.  So many newbies never bother to post anything on it.. 

(reminder to self - update my Profile)