oncotype and BRCA

I'm not BRCA positive, but how would you know that the oncotype score was higher because of BRCA?  Is BRCA added into the oncotype equation in some way, or is oncotype just based on the pathological characteristics of the tumor?  There are some types of tumors that are more common in BRCA positive women (triple negative), and that would make the recurrence risk potentially higher, but because the tumor is triple negative.

I'm BRCA 2 positive and my onco score was 70...I don't know too many people who have score that high.  But I'm practically triple negative (weak ER and PR positive) and I'm told that a higher onco is normal in that case, I think.  However, my doctor told me that chemo brought my onco score down to the 20's so I'm at the same risk as most breast cancer patients now.

hello,

i just recently had a bmx with TEs on march 6th. i had my first MO appointment yesterday and although my oncotype score was a 16 (in the low range) my tumor was consider a grade 3 but stage 1 with no node involvement and er/pr+ her2-. She seems to think that the benefits of chemo will not outweigh the risks and bascially only change my rate of recurrence by less than 2% which after hrt is 6%. I am wondering if anyone else with low oncotype scores but higher grade tumor chose or didn't chose chemo and why. my MO also explained that the onctotype pretty much trumps all of the other pathology. i am braca2 and had a hi KI67 score with poorly differentiated cells but that because my score was in the low range and there were no nodes and it is hormone receptive that chemo would not be recommended. that being said she definitely said there are women who still chose it--not exactly sure what i am feeling right now but would love to hear more from others with similar situations. i am also surprised because all of the original pathology indicated more aggression but as i mentioned she seems to feel that the oncotype trumps all. anyone else have a similar situation? I will definitely be seeking a second opinion mostly to hear the same thing and put my mind at ease to help make the decisions. i live in the philly area and would love any recommendations for MOs



thanks,

jsrose

Hi rebex,



Thanks for your note. I am actually going next week for a second opinion. I went last week to another mo in the Philly area and really didn't like the appt too much but she basically said the same thing. I am hoping the woman I see next week is a bit more authoritative in terms of her opinion. I am getting more comfortable with the idea of not doing chemo but still pretty scared either way.



When did they do your test? I noticed we had surgery a day a part. I got my results back pretty quickly. Maybe a week or so. Good luck. Hoping for a low score. Please let me know the outcome.



Jsrose

Hi, ki situation is very similar . My RS is 16, stage 1,grade 3, ki 67 37%, 1.5 cm, N0, M0. ER and PR positive, her2negative. I have seen several physician and I dont find two with the same treatment. What happened with you? Yes or no chemo?I am afraid to do a wrong decision. It is driving me insane.

Thank you very much

I am 45 years old

I wish the best for you

jsrose

I greatly appreciate your answer. Probably it is not what I wanted to hear, because I am not sure to want chemo, but I have much fear about my final decision. Probably, for me  it is the most dificult decision in the process .

Just one more thing, what treatment you are using?

Thank you very very very much

The best for you