Additional chemo treatment for Androgen positive

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carolyn27
carolyn27 Member Posts: 7
edited June 2014 in Triple-Negative Breast Cancer
Additional chemo treatment for Androgen positive
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  • carolyn27
    carolyn27 Member Posts: 7
    edited June 2013

    Hi friends, Diagnosed Oct '12 with 4cm mass and possibly 1 node involved. Received 6 cycles of T/C, followed by bi-lateral mastectomy. Final pathology showed small residual in mass in breast and a very small micrometastasis in 1 lymph node. Had surgery weeks later to remove an additional 18 nodes which all came out negative. Currently healing and planning radiation in the coming weeks. My tissue was tested and confirmed for Androgen positive and I have a KI-67 poliferation rate of 5%. Both of which I'm told are positive for a good prognosis. So here's my question ---- because of the residual disease post neoadjuvent chemo my Oncologist was considering additional chemo of Gemcitabine and Cisplatin. However, in the recent weeks my dr has learned and expressed that being positive for Androgen and a low KI-67 a better choice maybe to do a combination of Xeloda and Navelbine. Does anyone have any experience, thoughts or comments regarding the treatment plan that is being suggested??

     
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  • slowloris
    slowloris Member Posts: 128
    edited June 2013

    Carolyn, I am currently on xeloda, just finished my 2nd week, now a 1week break. Dx 7/2012 TNC stage III, 5cm mass, skin involvememt, atleast 3 nodes showed uptake on PET. dd AC 4x, 1 Taxol (bad reaction) 3 taxotere. bmx  12/2012 with breast recon te's implanted. 6 weeks of rads. finished end of march 2013. 6 weeks later, a peasized lump came up on same breast. Pathology from bmx showed NO residual tumor, no skin involvement in what was excised, and .3 mm metastases in 1/7 nodes so everyone thought my response was almost complete, yet the cancer came back. Original mo suggested carboplatin and gemzar for the recurrence. 2nd opinion mo from Hosp. of Univ. Penn suggested Xeloda. She said she didn't want to use all the "big guns" right away, this would be less toxic for me since I had such a fast recurrence.

    In researching these boards, I see that everyone I can find on Xeloda has stage IV mets. Some info I found in articles say they are now using it also for fast recurrences. My KI 67 on recur was 80%, original was 90%. I don't know about androgen. I don't know if a low prolif rate is normal for tnbc. Was path on tissue after chemo?

    In retrospect, I'm thinking that maybe neoadjuvant AND adjuvant chemo is the right choice for anyone that has residual disease, since rads did not kill alll of mine. My next appt is on the 19th, and I'm collecting as many qustions  that I can about treatment and decision making. Please let me know what you and your Dr. decide on, and I will surely keep you up to date on my progress. 

    Lori

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