Stage 0--->Stage I ~ Need Help Re. Interpreting My Reports
Being a "BC newbie" - wanted to ask collective "eyes" if any light could be shed on my BC results? I apologize for the long post (can you tell I type for a living?). I discovered a small lump in my L breast Feb 18. My PCP ordered a DX mammo Feb 26.
Radiologist MD who did DX mammo noted microcalcifications of interest near small lump cyst (which was B9), and ordered a Sterotactic Needle Core Biopsy - which I had done on March 19, whose Surgical Pathology Report stated:
- L breast, stereotactic needle core biopsy - ductal carcinoma in situ, nuclear grade 3 with comedonecrosis and microcalcifications. E-cadherin immunohistochemical stain is positive supporting the DX.
- Estrogen progresterone receptor (ER/PR) analysis: Estrogen receptor: Positive (>95% of nuclei staining; stain intensity: Strong); Progresterone receptor: Positive (>95% of nuclei staining; stain intensity: Strong). Staining of greater than or equal to 1% of the turmor cells is considered positive.
- Tissue analyzed: In situ carcinoma; Block number: A1; Internal controls: appropriately staining; External controls: appropriately staining; Fixation: Formalin-fixed paraffin embedded tissue. Antibodies: Estrogen receptor- SP1 Clone & progesterone receptor - 1E2 clone.
- Gross Description: Received in formalin are multiple segments of cylindrical tissue aggregating to 1.5 x 1.3 x 0.3 cm, yellow and of a soft consistency.
My BS ordered an MRI with IV contrast on April 10. Results given to me by BS were that due to "size of area of interest" shown in the MRI now at total area of 9 cm (= 3.5 inches), a lumpectomy I first opted for in my L breast was now "totally out of the question." So, then I made a personal choice of having not only a MX on my L breast, but also a prophylactic MX on my (totally normal and NO BC in) my R breast. Here are the MRI w/IV Path Report data:
- Bilateral enhancement is mild. There is a 9cm x 2cm x 2.3cm area in L breast at 2:00 middle depth & is a known BX positive for malignancy. This shows clumped enhancement & delayed washout type vascular enhancement. Angiographic measurement calculates an estimated volume of approx 4.4cc's of the known DCIS. There are no abnormalities seen in axillary nodes region. Impression: KNOWN BX PROVEN MALIGNANCY. SUMMARY: Left breast 2:00 moderaltely large area of known DCIS; NO AXILLARY ADENOPATHY. MRI BI-RADS: 6 Known BX proven malignancy.
Being cautioned & told by my medical team that above DX of DCIS/Stage 0 BC could very well change, upon my undergoing removal of Sentinal Lymph Nodes just before my BMX surgery, and final pathology report (produced April 30, 5 days post-BMX surgery) could uncover something very different! In fact, BS gave me Final Pathology Report (April 30) last week (stating only that NO cancer found in lymph nodes; but a very small microinvasion was found within the DCIS), as follows:
Lymph node, L axilla, resection: no tumor seen in 1 lymph node (0/1). L breast, mastectomy: small focus of invasive ductal carciona (1.5mm) arising in a background of extensive ductal carcioma in situ, intermediate grade, solid & cribriform types.
Comment:
Specifiment Laterality: Left. Proecdure type: Mastectomy. Wire localization: absent.
Tumor Size (size of largest invasivce carconoma) - greatest dimension of largest focus of invasion: 1.5mm.
Tumor Focality: single focus of invasive carcinoma.
Extent of Tuomor: Skin: Not involved. Nipple: Not involved: Chest wall: Skeletal muscle is absent not involved by invasive carcinoma.
Margins: Invasive carcinoma; uninvolved; Closest margin: 1cm, to the deep margin.
DCIS: Positive for involvement at the deep margin and radial margin at 1 o'clock.
Lymph-Vascular Invasion: Not identified.
Ductal Carcioma In Situ (DCIS):
DCIS is present; Type: Solid & cribriform type; Nuclear Grade: 2; Neccrosis: focal, small amount.
Lymph Nodes:
Number of sentinel lymph nodes examined: 1.
Total number of lymph nodes examined (sentinel and nonsentinel): 1
Number of lumph nodes with macrometastases (>0.2cm): 0.
Number of lymph nodes with micrometastases (>0.2mm to 0.2cm and/or >200 cells): 0.
Number of lymph nodes with isolated tumor cells (less than or = to 0.2mm and less than or = to 200 cells): 0.
Number of lymph nodes without tumor cells identified: 1
Size of largest metastatic deposit (if present): Not applicable.
Extranodal Invasion: Not applicable
Pathologic Staging (AJCC 7th Edition): pT1 pN0
Estrogen & Progesterone Receptor: Pending
HER2/(ERBB2): Pending
Clinical Data: Carcinoma in situ of breast (233.0)
INTRAOPERATIVE CONSULT DX: Sentinel lymph node, left axillary biopsy: Negative for malignancy. Final diagnosis pending permanent sections.
GROSS DESCRIPTION: Lymph node with attached adipose tissue measuring in aggregate 3.0 x 2.0 x 1.0cm. The lymph node measures 2.5cm in greatest dimension.
The L breast measures 15.0 x 15.0 x 6.0cm, and weighs 645.0 grams. Margins of specimen are marked with black ink. Specimen is serially sectioned; 3 separate possible masses are identified. 1st mass is located at 4:00 location & consists of tan-pink, firm, ill-defined fibrous itissue surrounding an area of hemorrhage measuring 1.2x 1.2 x 0.7cm. This mass extends to within 1.0cm of the deep margin. 2nd possible mass is loated at 3:00 location & is posterior in depth measuring 1.5 x 1.0 x 0.7cm. It also consists of tan-pink, ill-defined, fibrous tissue srurrounding an area of hemorrhage. This mass extends to within 0.5 cm of the posterior margin. 3rd possible mass is located at 1:00 location & is anterior in depth extending to within <0.1cm of radial margin at 1:00. Mass consists of tan-pink firm tissue & measures 1.0 x 0.8 x 0.5cm. Mass rrounds an area of hemorrhage. Xray taken identifying metal clip. Representative sections are submitted as follows: B1-B10 mass 4:00 location totally submitted with adjacent tissue, any ink present is the deep margin, B11-B17 possible mass at the 3:00 location totally submitted with adjacent tissue, any ink present represents the deep margin, B18-B22 possbile mass at 1:00 location totally submitted with adjacent tissue, black ink present represents the radial margin at 1:00, B23-B25 contain sections of remaining breast tissue as follows: B23 lower outer quadrant, B24 lower inner quadrant, B15 upper inner outer quadrant, B26 nipple. The specimen was removed from patient at XXXX hours & placed into formalin at XXXX hrs.
Given the above, I'd appreciate anyone shedding some light as to what the above means. I also hope, since I had a BMX, I can avoid having to do chemo and/or radiation therapy?? (I'd prefer the latter vs. the former!) I think the hardest part of my dealing with BC is test... then waiting for results... another test... waiting for results (and yada, yada...!). Enough to really unsettle you, if you do not have any support system or "relief valve" in place!! ![]()
Any input/thoughts? Very much appreciated! Thank you! Right now, I am praying for the day when BS will FINALLY remove these pains-in-the-a** remaining 3 JP drains I've been lugging around me since April 25!! (fingers crossed... I think their collective output is FINALLY slowing down to almost nothing! TG!!!) ![]()
Comments
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With a 1.5mm invasive cancer you are stage 1a, with no nodal involment but you do have a larger area of ductal carcinoma in situ which is NOT invasive. You have to wait for your ER/PR/Her2 status, but if it is ER+/PR+/Her2-, you will very likely not need chemo. (likely since your DCIS is strongly ER/PR+/.No LVI, means no lymphvascular invasion, which is good. Hormone therapy would be offered. VERY good prgnosis. If you are ER-/PR-, Her+ or -, then they may offer you chemo because triple negative and her+ cancers can be very sneaky even when incredibly small like yours and without hormone therapy, there's nothing else to treat these sneaky ones but chemo and/or herceptin. Let's hope you'll be in the majority here, though!!!!!
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Thank you so much, Bluepearl (I just adore your screen name!!)
1 more question, if I may: since I had the BMX, do you think I'd still have to undergo rads of any kind (L breast only area)? Would be nice if I can skip that, after all I've been through (so far). Many thanks, Bluepearl!! 
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If you had a mastectomy with clear margins, no skin, chest wall or lymph node involvement, which it seems from the above, then you will not need radiation.

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rc1 is right.......((hugs))).....the rest of the stuff in your report isn't important for you but they state it for medical oncologist and for future references if needed....big words and they all sound scary but are not. I had alot of "tan-pink" tissue and hemorage type stuff (due to biopsy I think)....not to worry.....but we do especially waiting for test results UGH!!!!
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Just saw BS yesterday and then the MO he referred me to (I may get a 2nd opinion from a different MO, who successfully treated my mom - still cancer-free stage 2b lung cancer 4 yrs now -- and whom I think I'll like a lot better.) I was utterly shocked to learn that (with the above final path report MO also gave me yesterday, w/no changes) he can only offer me a 75% chance of survival 10 yrs out from now - and 85% if I take 2.5 yrs of Arminidex followed by 2.5 yrs of Tamoxifen, IN THAT ORDER. Said that way it's to INCREASE survival (didn't note the % on that one).
Has anyone heard of such a thing?
He said no chemo (TG), as it'd offer like 1% increase in survival. Yet, he referred me to POSSIBLY having rads (you GOT to be kidding, even after a BMX???!!!). So I'm to visit a radiologist MD tomorrow for HIS opinion. For such a micro-amount??? Stage 1a??? MO said likely I may NOT need the rads - but I think he's being a bit too cautious. He seemed to pooh-pooh my fears re: SEs from both meds ("there's a PRICE to pay, you know?").
Any help here or insight would be appreciated - and I do thank the posters for their replies - thank you!!!

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The rads would be offered based on the DCIS, not just the invasive part, but after a BMX with no nodal involvement, it would only be if the margins near the chest wall were very small.
As I said in your other post, I would definitely ask for a second opinion. You will be with your MO for a while, most likely, so you need it to be someone you feel comfortable with.
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There are rad regimes that increase survival among mastectomy patients even without involved nodes or chest wall involvement. There's a name for it but I can't drag it up in my brain right now, but it works. Anti-hormonals do increase survival and with tamoxifen, that effect lasts years later even after stopping it (after the 5 year limit)...some women are advised a total of 10 years of tamoxifen now. Not knowing the her2 status, if it were negative, I would say 85% is a bit low......more in the 90%+ range with anti hormonals. Second opinion required to ease your mind. Congrats on 4 year survival re: lung for your Mom......one more year and she'll be considered cured!
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Thanks, bluepearl! (LOVE that name!!) I spoke w/my CNP, who'll arrange for me to switch (my call) over to Dr X, same MO MD who treated my mom (thanks for the nice note re. her: she's 83 next month, lives w/my 2 sisters in Chicago suburb, and even last year underwent gallbladder/gallstone removal - 3 surgeries!! I told her she'll outlive ME!! LOL! :O). My family loves Dr X, so does my Brother & SIL (who reminded me he had a cross on his office wall - I forgot - we share same religious faith!). An added benefit? He's younger than me... I recall my DF telling me long before he passed away 8 yrs ago "to always choose a MD younger than you are." And, I'm totally now at peace with my decision. Bluepearl, I really DO need a good personality/caring MD who WILL help me thru the rough patches as I soon will embark on my hormonal therapy (and not be too callous re. my symptoms & such). It's also a personality issue. His staff are the "kissy-huggy" type -- which is like what I really DO need now (even at 58!), as DH works long hours/3 jobs and I have no kids - just a 12 yr old Golden Retriever at home -- and a HIGHLY HIGHLY stressful employment!

This new MD, I really DO believe, will add some much needed rays of sunshine - - akin to what you and all my new BC sisters have been to me on these boards!
One more thing: MO yesterday didn't care for Oncotype (only pertains IF chemo may be needed, I think?), or seem concerned when I asked about HER-2 (?) etc. Plus, this Dr X is soooo easy to talk with! My mom still, to this day, misses him... she may have some dementia, but never ever will forget him and/or his kindness to her in her lung cancer rads treatments!!
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Actually, I just put in your stats for over all survival and it's well into the 95%+ survival. You'll likely die from something else WAY before BC cancer visits you again!!!! Opps...another post I was referring to regarding hormonal therapies....I am speaking about "CAncermath" site where you put in your own stats to find out a general over all survival.
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Well ALL need kisses and hugs when we are facing cancer! Actually, we all need them even when we are well!
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Thanks, bluepearl -- too bad (we both love BLUE!?) I can't "write" my text here in blue... you were reading my mind... you'll see my post on another board, giving you some {{{hugs}}} -- which I'm sending to you again!!
On separate topic, I read the other day (due to flat tire, and DH working from sunup to sundown on that day) an e-book, called "Unbroken" - great read - unbelievable odds - just what the Dear Lord may have meant for me in the BC fight of my life I'm in to give me some needed courage (and boy, that book did it for me!) Was on NY Times bestseller list forever (author is Laura Hillenbrand? sp?). And as I'm typing this, I could not help but call to mind the late, great Leo Buscaglia (sp?) who advocated HUGS!!!! to one and all -- I'm dating myself here, but really LOVED to watch him in the 1980s/1990s on PBS! WHAT a motivator! I may just (while still on STD until 5/28) look & see if any of his titles are "e's"!
{{{{Hugs}}}}} to you, bluepearl (and all my BC sisters who read this)
BTW: did you all know how much I absolutely LOATHE the color PINK??? LOL I told my DH's sister (SIL) that IF I ever do a Komen or BC walk, I'll stick out like a sore thumb, 'cause I told her, you'll NEVER EVER catch ME wearing PINK! I'll be the (only one) wearing turquoise blue in the crowd!!! ROTFL!! :O My family for years has known my "fetish" for the color turquoise blue - goes way back to like 1967 or 1968, oh my!!! :O
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I t looks like you were offered radiation because it appears you have positive margins. I had BMX August 2011 and had + margins...boy was I ever royally pissed off. I went through all that and needed more treatment, because the doctor didn't take out enough? I had numerous second opinions. Yes, I probably wouldn't have needed rads is the doc had removed my fascia. I still to this day don't understnad why he didn't. I also had numerous second opinions about rads. Yes, all in agreement I needed rads. In the end, i was glad I had radiation. My tumor was 4 cm (originally thought it was 2 cm on MRI). My path report said they werent even sure as it was hard to measure and had to measure by palpation (???). My tumor wasn't seen on mammo or ultrsound. i had no lump. I only found out I had cancer because I asked for a screening MRI due to family hx. And it turned out to be 4 cm. So basically I thnk my cancer was "weird" and i'm glad i got zapped. I had immediate reconstructive surgery so my rad side sits a little higher and is a little firmer, but it's nothing a bra can't fix.
i would get second opinions about radiation.
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turquoise
Why not get the Oncotype test ...its to determine your rate of distant re-occurance........you never know ...you may have a high score like you may have a low score .....it gives you more knowledge about what your dealing with ....
If its high you may need chemo.
Also , how old are you ? Are you premenopausal ? Did the Oncologist mention ovarian supression ? Just curious .
I have somewhat the same stats and waiting for my onotype test .
Will likely be doing Zoladex and tamoxifen ( as long as my score is not high ) ....
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Strange to say, I asked my BS and CNP, both of whom stated an Oncotype was not really needed, as the MO I saw the other day (whom I will no longer see) said Chemo would only give me only a 1% xtra survival -- but the risks to me would far outweigh any benefits it would give me (a waste, said he). Also that Oncotype VERY $$, and "really only needed if chemo may be necessary." But my BS did tell me -- flat out, emphatically -- that rads were NOT needed, that all the BC was out of me, yes, the margins were all clear, etc. Even took great pains to go over a huge illustration of a cutaway of layers of skin (and under it) in the body, and what he did in my BMX surgery.
I think that both Drs (radiologist & my BS) really have to TALK to each other (they're like 30 miles apart, in 2 totally separate entities but onder one huge medical center name; a brief written path report to read on a computer IMOHO is NOT sufficient to discuss a mutual patient's DX and prognosis!
I was kind of dismayed in asking yours truly ti get the info & get input to the rads MD - that is what I'm paying the BS to do!
Just like e-mail never gives the recipient a "true indication" of the "realistic" and full communication intended by the sender, same I think is between these 2 MDs. 
In any event, I told DH, my mind is made up, and I will not do rads... 5 yrs+ on the drugs soon to come & the bad SEs I'll have to do & risk is MORE than enough for me. Enough is enough! A futher reason for my BMX is so that I would NOT have to do the rads!
Further, I do want to leave the door open for possible recon - which radio MD said would not be doable if I DID have rads (due to skin issues from rads). Rads MD further stated that for me to have rads does NOT increase my survival % chances (which was also told to me by MO I will no longer see for my BC). I am 58 and post-meno. I'm still scratching my head (as are my BS and CNP) as to why the MO I only saw once even THOUGHT I should get rads... to me it's overkill, and a huge cash cow for the medical team. I'm trusting my BS, who took great pains to explain why I do not need rads (in his opinion). I just kind of hated being placed in a non-clinical postion between the 2 of them. Go figure! I will be seeing a new GREAT MO I chose in coming week or 2 (my mom saw him 4 yrs ago for stage 2b lung cancer, had rads, and is CA-free to this day). Radio MD respects my decision, but said he'll be talking to my BS on Monday...
Lastly, I was asked by my BCC to research re. positive margins/post-meno/outcomes with rads... top-name govt (not Dr Google) all stated rads NOT needed. So consistent with what my BS and CNP were advising. I met a lady who was DX'd with Stage III BC at my gym's Zumba class... she flatout refused Chemo & drugs... still here 13 yrs later.... what a crapshoot BC is (I was told as much by many)...
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Just an update, friends....
At suggestion of the new MO I saw 2 weeks ago (who stated that having rads done IS "standard of care" for someone like me, who had positive margins, even with DCIS), I met with a great (nice!) MO at the cancer center. Knowing my concerns re. rads and SEs I'm concerned about (being a MI survivor, my BC was in my L breast, leading to likely heart & lung issues, not to mention LE I hope to avoid at all costs, etc.!), RO introduced me to the TOP (and she is FANTASTIC!) female BS he teams with, who's also BC director of the hospital, who examined my BMX scars and dog ears.
RO (and lady BS) brought up fact that I may NOT need rads - which, said my RO, are MUCH more $$$ vs. surgery!!). This would apply in my case, IF and ONLY IF, my BS #1 was able to remove fascia/go down to entire chest wall to remove DCIS (the 1.5mm IDC was well hidden within the DCIS, and that, TG, DID get clear margins!) at time of doing my BMX in April.
Unfortunately, BS #2 (lady) said only way to know for sure is if she could do an additional surgery and get its path report to verify this. Apparently, bottom line is, if BS #1 did not remove 2 layers of fascia (who knows??) and BS #2 can do that, then i may NOT need rads. Or so I was led to believe. In any event, I meet with BS #2 (boy, how do I regret now I didn't have her do my BMX in the 1st place!!!!
) on June 11 for consultation appt. Then, 1 step at a time...Other issues I'm having are sometimes uncomfortable/painful side dog ears, and I am (since my BMX) adamant about NOT having reconstruction (which RO also addressed & asked what I want to do, given rads issues with recon). Since my BS #1 left a lot of xcess skin in both breasts IF I DID want recon (wasn't sure 2 months ago, I was a DD size bra cup!). Also, my return-to-excercise-post-BMX attempts at my previous light jogging I loved is now very uncomfotable with my "dog ears," AND the flabby excess skin all around (front & back) is VERY difficult for me to do breast self-exams going forward to check for "lumps" etc. So, in essence, surgery by BS #2 may serve 2 purposes - medical and cosmetic. Only hope my Anthem BCBS plan will cover it all! (fingers crossed!) Or she may refer me to a PS to remove the excess skin... would THAT be covered by health insurance as a recon would? Anyone know????
I sure as he** hate to be doing this all again (TG, no nodes removed -- but BS #2 said I'd have the dam* JP drains again - but only for a week -
- and no swimming for 2 weeks
), IF my insurance approves it all (?) I know.... 1 step at a time... and isn't that what we all with BC have to do? One day at a time... one step at a time... all in the RIGHT direction for us! 
Thanks for your insightful help!!

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