Clinical Trial For IBC

tinkers2
tinkers2 Member Posts: 35
edited June 2014 in IBC (Inflammatory Breast Cancer)

Hi Everyone,

I have been thru chemo, and just recently had a masectomy. They are offering a clinical trial using a drug veliparib

and radiation.  It's to see if the drug helps the radiation work better.

I don't know what to do and whether to participate in this trial.

I had a complete response to my chemo and my onc was very happy. 

I asked my onc if they would do the trial if they had ibc.  Onc said yes, because there's really nothing treatment wise

for IBC.

So I guess I'm looking for advise, suggestions on this. 

Thanks for your help.

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Comments

  • liv-
    liv- Member Posts: 521
    edited January 2013

    hi tinkers -  only you can decide that and perhaps if your onc says yes that is as good a recommendation as any..

    its a trial so none of us know until the trial is finished and they print stats/outcome.

    hope you find the answer your looking for, its probably right there within you.

    best of luck,

    xx

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  • Moderators
    Moderators Member Posts: 25,912
    edited January 2013

    Hi Tinkers,

    We're sure others will be by shortly to offer their ever-helpful advice on this, but in the mean time, you may be interested in checking out the main Breastcancer.org site's section on Clinical Trials, specifically, the What Should I Know Before I Decide to Be Part of a Clinical Trial? page for some questions to ask before you decide.

    Hope this helps!

    --The Mods

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  • tinkers2
    tinkers2 Member Posts: 35
    edited January 2013

    Thank you all for responding.  Yes, it truly is a gut decision.

    Bonnie, you're a wealth of information. Thanks.  How do I found out about clinical trials past and present and their outcomes in other countries?  I hope you or someone who knows can tell me how to do this.

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  • liv-
    liv- Member Posts: 521
    edited January 2013

    hi tinkers

    how did you go, did you go ahead?

    thx bon for link to trials.

    for any australian IBC ladies/gents

    -Afatinib (BIBW2992) in HER2-overexpressing Inflammatory Breast Cancer.

    http://clinicaltrials.gov/show/NCT01325428

     

    bon is the trial just for her2-?

    thx lovely

    x

    Overexpression of the human epidermal growth factor receptor 2 (HER2) predicts a poor prognosis in metastatic breast cancer. While the introduction of HER2-targeted therapies, such as the monoclonal antibody trastuzumab and the small-molecule tyrosine kinase inhibitor lapatinib, has significantly improved outcomes in HER2+ breast cancer compared with previously available therapies, use of these targeted therapies is often limited by the development of drug resistance and tolerability issues. These limitations create the need for further development and investigation of new targeted therapies that show potent and selective inhibition of these targets or closely connected molecular pathways. Recently, several agents have demonstrated promising activity in HER2+ metastatic breast cancer, either as monotherapy or in combination therapy, including the tyrosine-kinase inhibitors neratinib (HKI-272) and afatinib (BIBW-2992) and the anti-HER2 monoclonal antibodies pertuzumab and trastuzumab-DM1 (T-DM1). Agents that target other molecular pathways, such as the vascular endothelial growth factor receptor, mammalian target of rapamycin, PI3-kinases, insulin-like growth factor (IGFR), HSP-90, and other kinases also have potential, in combination with anti-HER2 and/or other systemic therapies, to be active in this subtype of breast cancer. Innovative clinical studies are required in well-characterized patient populations to define the true clinical value of these emerging new approaches.

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  • tinkers2
    tinkers2 Member Posts: 35
    edited January 2013

    I decided not to do the clinical trial.

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  • tinkers2
    tinkers2 Member Posts: 35
    edited January 2013

    I tend to second guess myself sometimes, as I think alot of people.

    I felt fairly confident in my decision. No going back now.

    My surgery was about 6 weeks ago.  I started rads last week.

    I go back to work tomorrow. Not looking forward to it,but it will

    keep my mind busy.

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