Ovarian cancer in TN's??

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julibug63
julibug63 Member Posts: 12
edited June 2014 in Triple-Negative Breast Cancer

Oh my it has been so long ladies since I have been a visitor to these boards! I am very blessed to be 5 1/2 yrs out from diagnosis...but I was wondering if anyone could direct me to any threads about the stats on ovary issues in TN's.

About 3 weeks ago I started having that feeling that I was ovulating on my right side. You know, that pressure feeling and pain in that area when i walk..I have been in chemopause since second chemo infusion at age 43. I do have an appt with my primary care Dr in 3 weeks but of course I want info now! Anything that you ladies can offer me would be great!

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  • jenjenl
    jenjenl Member Posts: 948
    edited December 2012

    I am kinda new to this but are you brca +?  Your chances are higher if you are +.  I'm not sure of the correlation of TN and ovarian issues.

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  • Yayme
    Yayme Member Posts: 107
    edited January 2013

    Hi



    I am BRCA 1 + , and have had ovarian cancer 17 years ago, thank God I caught it very early....then diagnosed with triple negative stage 1 this past summer...I would say, and have been told by many Docs that there is an 87% risk for recurrence of BC and development of ovarian cancer...so please take the info very seriously and start making plans to take precautions.....I say this only out of concern and personal experience.

    Blessings

    Lisa

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  • SelenaWolf
    SelenaWolf Member Posts: 1,724
    edited January 2013

    I have read somewhere recently that triple-negative breast cancer is more closely related to ovarian cancer than it is to other breast cancers.  Will try to reference the articles and post links...

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  • Yayme
    Yayme Member Posts: 107
    edited January 2013

    Selenawolf...I have heard that too...I have donated some of my tissue to Dana Farber for their research as did many of my family members who carry the same gene...as I I dear stand, ovarian, TNBC, and Prostate cancers are very closely related...this is one reason why they are thinking of testing Androgen receptors for all breast cancer patients soon. 25% of TNBC present with Androgen receptors and 50+ percent of E+P+, also present with these receptors as well...also seen on sometimes on ovarian tumors.....

    The Sanantonia Symposium had some additional info on that very subject in December...

    Lisa

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  • Luah
    Luah Member Posts: 1,541
    edited January 2013

    To the extent that TNs are more likely (than ER+) to be BRCA+, there may be a stronger link to ovarian cancer. However, the majority of TNs are not BRCA+. Were you tested, juli?

    I too have read the recent findings that, biologically, TN is similar to ovarian... but what that means in terms of risk analysis or treatment options is, I believe, a long way off. 

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  • julibug63
    julibug63 Member Posts: 12
    edited January 2013

    Thank you ladies for your posts and info...no, I was never tested. I think I am going to request to be tested, if only for the precaution for my 3 adult daughters. I go to see the primary care Dr next Friday so until then...I will just try not to worry!

    Thank you again! I always know that I can find answers and support here!

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  • mbamja
    mbamja Member Posts: 1
    edited April 2013

    Hi Juli-

    I am very interested to hear how you are doing and what you found out about your new "issues".

    I had my first TNC dx in 2006.  I had / have been in chemopause since also.  I was 38 when dx.  Just one week ago I had the same issues but thought it was a bladder infection coming on... low and behold I started spotting and have been since thursday.

    I too have an apt with my primary care dr in May.... my mom passed from ovarian cancer.  So I am a little concerned, especially reading the above about the link between these two beasts!  I was tested and showed negative on the BRCA.

    Best wishes to you on all the gals on here...chin up and live each moment for its own :)

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  • Yayme
    Yayme Member Posts: 107
    edited April 2013

    Hi mbamja...



    Hi..I am sorry about your mom...and your TNBC diagnosis, but glad to see you are a survivor....I was diagnosed with Ovarian cancer when I was 35 years old... 17 years ago.I was recently last June diagnosed with TNBC...I did test positive for BRCA...however there is a family link, as my mom..aunts also have breast, some breast and ovarian.....one of them tested negative for BRCA..so I have heard of cases where later on your can show the mutation..there are some ladies in this forum that had that experience as well....they are finding various mutations, genetically TNBC and ovarian is felt to be associated to not only BRCA 1 & 2, but research has now found other mutations that triple-negative breast cancers and ovarian are possibly driven by.....a diverse group of genetic alterations, MYC, MCL1 and JAK2, p53 amplifications as well as mutations in the PI3K pathway ..

    So I say, keep vigilant and follow your instincts.....genetics are very individual and one mutation can act entirely different from another...

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