PR+ cells add prognostic value in luminal A breast cancer

This study is interesting to me.  I've wondered for some time what the % of PR+ was needed for a better prognosis in ER+ BC.  I don't know that this has nailed it down, but it seems to be a more definitive study than the others I've read.  Since the 14% cut off for Ki67 is still debated, I'm sure this won't be the end of this discussion.  

So the next question to answer, "What is the % ER+ threshhold for effective treatment with antihormonals?"  I've read this question asked over and over on this site.

Another question I'm asking is, "Since Tamoxifen is less effective than AIs in treating Luminal B, at what % PR+ and Ki67 does this become an issue?"  

I'm facing having to consider switching from AIs to Tamoxifen because of a serious and rare eye SE that's reappearing after switching from anastrozole and starting exemestane after an 8 week break.  Looks like it might be a low estrogen problem because these two meds are chemically different.  Based on this study I'm solidly Luminal B, my 5% PR+ was always the question.  Tamox may not be worth the switch if it's not going to be effective.

Anyone heard of someone using estrogen eye drops when taking AIs to manage eye SEs?  I suspect it's much riskier than local  vaginal estrogen treatment since BC mets occur in the eye.  I need to chew on some treatment options before I return to my MO and Ophthalmologists with the bad news that the vision loss is returning.

pamelahope - You've done chemo, BMX and I'm guessing now doing an antihormonal med, so all the right things to prevent a recurrence.  Work on all the other things that help prevent recurrence - diet, weight, excercise, mental health - and you are doing what you can to prevent its return.  That's all we can do.  As with triple negative and HER2+, Luminal B is not a death sentence.  It is a heads up that if there are bumps in treatment, like severe antihormonal SEs, you need to find ways to stay on the med.  Or at least be fully aware of the risk or recurrence if you stop the meds.