Genetic Findings Could Reshape Approach to Breast Cancer

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cp418
cp418 Member Posts: 7,079
edited June 2014 in Clinical Trials, Research News, Podcasts, and Study Results

http://www.generalsurgerynews.com/ViewArticle.aspx?d=In%2Bthe%2BNews&d_id=69&i=December+2012&i_id=916&a_id=22264

Genetic Findings Could Reshape Approach to Breast Cancer

Four Distinct Subtypes Found; Genetic Makeup of Tumors More Important Than Location; Research Brings Promise, and More Questions
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  • dlb823
    dlb823 Member Posts: 9,430
    edited December 2012

    An excellent explanation of earlier-announced research.  Thanks for finding and posting this!    Deanna

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  • wallycat
    wallycat Member Posts: 3,227
    edited December 2012

    This article confused me....4 subtypes?  Didn't they recently have an article in Nature saying there were 10 distinct types?  And if luminal A types make up the most cancers, the statement that 40% of luminal A death compared to luminal B "years later" statement doesn't make sense; if luminal B includes HER2+ and now this is not considered a "type" under luminal B but its own category....

    and 40% death....at what interval?

    If anyone can add anything to the article, I would love to hear it.  Also, if you are recently DX, does path report indicate luminal status?  I don't know if I want to look back at mine.....

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  • cp418
    cp418 Member Posts: 7,079
    edited December 2012

    My understanding is that a patient can be ER+, PR+, HER2neg as either Luminal A or B. They are using a KI67 cut off of 13-14% to maybe categorize Lum A vs Lum B.  14% and less is Lum A and > 14% is Lum B.  So it appears Lum B can be either Her2 neg or Positive from my interpretation......

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  • wallycat
    wallycat Member Posts: 3,227
    edited December 2012

    Thanks cp418.

    The more they know the less I understand...

    I guess I wait like a sitting duck hoping for the cure, sooner rather than later.

    I still don't know if they checked for luminal a or b on my path....anyone else??

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  • doxie
    doxie Member Posts: 1,455
    edited December 2012

    wallycat - whether you are luminal A or B will not be stated on your path report, at least not yet.  Right now the difference is a moving target anywhere from PR+ <1-20% and Ki67 >14-20% will put you as Luminal B with HER2 -.  At least that is the range I've read in studies.  I've not found a % for ER positivity threshhold.  Seems it's the PR and Ki67 (and sometimes grade 2-3) that is mentioned.

    Check out "PR + cells add prognostic value to luminal A breast cancer" posted by cp418 in this same forum.  

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  • wallycat
    wallycat Member Posts: 3,227
    edited December 2012

    Doxie, thank you for your post.

    I read everything CP418 posts and maybe I am just reading too much...they simply don't know a lot of the answers yet and I am banging on the door, wanting them Tongue Out

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  • cp418
    cp418 Member Posts: 7,079
    edited December 2012

    wallycat - no point in making ourselves crazy as the research continues and treatments get updated and changed.  We cannot go back in time, we can only go on from the present. HA -- easier said than done though!

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  • wallycat
    wallycat Member Posts: 3,227
    edited December 2012

    CP418,

    I think I have driven myself there ...and back...the crazy place!

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  • Timbuktu
    Timbuktu Member Posts: 1,906
    edited December 2012

    Wally, my thoughts exactly!

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  • Timbuktu
    Timbuktu Member Posts: 1,906
    edited December 2012

    Wally, my thoughts exactly!

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