New Research-Fermented Soy

HAELAN RESEARCH FOUNDATION
Website:  www.haelanresearch.org

Dear  Recipient:

You have heard me lecture before on cancer and am updating you on our latest peer reviewed research and publications.  I appreciate your  interest in our research with fermented soybean beverages for the prevention and treatment of cancer and other chronic diseases.   The information you are receiving will give you a basic concept of our science and achievements. 

In order to recognize our scientific advancements we must first recognize the term "cancer stem cells", their origin, the fact that neither chemotherapy or radiation kill cancer stem cells and the fact that our fermented soy does kill cancer stem cells.  This is shown in the attached peer reviewed article dealing with treatment resistant cancers and "survival".

1. In any tumor, 99.1% to 99.9% of the cells in the original tumor are non-malignant cancer cells. These do not hurt people unless space is limited, like in the brain, and they can't spread to vital organs.
2. In any tumor .1% (1/10th)  of one percent to not more than .9% (9/10ths) of one percent of the original tumor cells are cancer stem cells. These are the ones thak kill people. 3. Chemotherapy and radiation do not kill cancer stem cells, they only selectively kill the non-malignant cells in the tumor.  In addition, chemotherapy blocks cell differentiation and increases the numbers of cancer stem cells that are treatment resistant with conventional chemotherapy and/or radiation treatments. This is why the death rate from metastatic cancer has not dropped in the last 30 years.  This was published in CANCER RESEARCH in 2006 and confirmed by Dr.Max Wicha University of Michigan stem cell expert on the following u-tube link:

http://wn.com/professor_max_wicha__breast_cancer_stem_cell_regulation

With regards to  your inquiry regarding some of the aspects of the Haelan fermented soy that has been used by cancer patients for more than 20 years in the United States for cachexia and its anti-cancer benefits I have summarized some of the research in this overview and have it available as "electronic Adobe PDF files", which are attached to an e-mail I sent to you. 

This is a small portion of the research in our files but the attachments show both safety and efficacy in sole therapy applications and in its use with chemotherapy to reduce cachexia  which is shown in the peer reviewed multi-center hospital study attached (# 9003).  The fermented soy does not reduce the effectiveness  of chemotherapy or radiation treatments.  It shuts off the mutation pathway (NF-Kb) 100% and is reported to increase cancer cell kill as much as 8-10 times greater than chemotherapy by itself on "treatment resistant" cancers.  This is in conformity with  the "survival" charts shown on page 464 in the "Treatment Resistant" breast,ovarian and prostate cancer study published in the attached study (#9001).   The comparison to Doxorubicin (Adriamycin) on breast cancer in the attached Townsend Letter article, #9200(a) and 9200(b),  shows approximately 500% superiority over the Doxorubicin (Adriamycin) in increasing the cancer cell's pro-apoptotic gene expression ( BAX) and a 50% reduction in the anti-apoptotic gene expressions.(Bcl2).

Because our research involves a complex nutritional product that falls in the "food" category  the FDA does not allow disease claims or advertisements for products without extensive expensive clinical studies to establish safety and efficacy.   Therefore,  the fermented soy has not had the exposure it should have.  In addition,  most people believe  soy phytoestrogens  are  estrogens, make cancers grow quicker and increase feminine  characteristics in men.  Studies show none of this is true.  In this area I would like to point out the fact that a highly successful PTSD  study using Haelan  showed the Haelan soy formulation  doubled the testosterone levels of young Elite NATO military soldiers suffering from PTSD, which brought them up to normal testosterone levels. Soy phytoestrogens are not estrogenic  and are in fact anti-estrogenic.  In addition,  they have very effective anti-cancer properties and many beneficial mechanisms of action for the cancer patient which is shown in the information attached to this e-mail.   I have attached two articles I wrote to clarify misconceptions about soy.  The management of estrogens, estrogen receptors, estrogen metabolism and cellular immunity are important in the treatment of cancers because it improves treatment #9001)  .  In addition, everyone needs to recognize that all soy products are not created equal.  This  is clearly shown in the comparison between Haelan and pharmaceutical company soy products shown in my attached article. (See # 9100 )The Haelan fermented soy product has many anti-cancer mechanisms of action and an overall efficacy that is competitive to chemotherapy treatments in sole therapy applications. (#9200-a and #9200-b )    In addition, when used in combination with chemotherapy the product enhances the effectiveness of chemotherapy treatments  because it has an  improved  Bcl2/Bax ratio, lower multi-drug resistance (#9200-a & #9200-b), shuts off the NF-kB  mutation pathway of the cancer cells, has anti-angiogenic properties (#9250) and overcomes treatment resistant of cancer stem cells by causing cell differentiation and pro-apoptotic gene expressions within those cells. (#9000 & #9001) )  The decreased changes in the Bcl2/BAX ratio, which is a surrogate marker for NF-kB,  for Haelan is as follows:
            Breast cancer BT474              -94%
            Prostate cancer, LNCaP          -52%
            Liver Cancer, HepG2             -64%
            Colorectal Cancer, SW480     -52%

The Bcl2/BAX ratio from human cancer patients' circulating tumor cells was as follows:
            Breast Cancer                         -20%
            Prostate Cancer                       -94%
            Ovarian Cancer                       -80%

The data stated above is shown in the following publications attached for your review:
1)  a case report from the Harvard Medical School recommending clinical studies with the Haelan fermented soy for "Platinum Resistant Ovarian Cancer".  This case study was paid for by the National Cancer Institute in the United States. (Item # 9300)
2)  Two peer reviewed articles published giving data on apilot trial performed in Germany on "treatment resistant" breast, ovarian and prostate cancers (Items #9000 & #9001).  This information includes long term results (4 years) patient survival data after the end of the study. (Item  9001)
3)  A multicenter trial, placebo controlled, with 270 patients suffering from various types of cancers.(Item #9003)

In summary, the following research achievements have been published:
References:
Peer Reviewed Scientific Publications with fermented soy (formulation FSWW08)
1) Report of a Single Case : Knock Down of Treatment Resistance by Paclitaxel
Harvard Medical School Boston, USA
Klein A, He X, Roche M, Malett A, Duska L, Supko JG, Seiden MV. Prolonged stabilization of platinum resistant ovarian cancer in a single patient consuming afermented soy therapy. Gynecol Oncol 2006;100:205–9.
2)  Pilot Study of Knock Down of Cancer Resitance by FSWW08  
Germany, EU
Jacob U, Gocan A, Bachg D, Rohr U. Application of fermentted Soy in Cancer Patients to reduce Cachexia, a prospektive Pilotstudy. J Gynn Endokrinol 2009;16:18 – 28.3)3) Long Term Results of Increased Survival and Knock Down Resistance of Cancer Patients
Germany, EU
Gocan AG , D Bachg, AE Schindler, U.D. Rohr. Managing immunity in resistant cancer patients correlates to survival: results and discussion of a pilot study Horm Mol Biol Clin Invest 2011;8(2):455–469
4)  Multicenter Study, Placebo Controlled with 270 Patients
Complete Removal of Cachexia during Chemotherapy and
Normalizing Hematology

China,
UD Rohr, W Wainright, H Ziejiang, AE Schindler. The Effect of Fermented Soy (FSWW08) on Blood Hematology and Cachexia in Cancer Patients, Horm Mol Biol Clin Invest 2012 in press

Most important Findings
The Haelan fermented soy product shows identical results in
            a) several clinical trials
            b) in several continents and in
            c) different races

Excellent pharmaceutical control of manufacturing and quality control

  The important thing to recognize is that the Haelan fermented soy technology has the ability to overcome cancer stem cell resistance and produce impressive patient results on glioblastomas, cholangiocarcinoma  and some other tough cancers  where it always improve the quality of life, lengthen life spans and often produce cancer free patients when the results with  conventional chemotherapy and/or radiation treatment results have been poor.

 Very truly yours,

HAELAN RESEARCH FOUNDATION


Walter H. Wainright, President