DCIS that is ki67+

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Mcall44
Mcall44 Member Posts: 18

I was dx via MRI bx on 9/14 w 1.7 cm intermediate grade DCIS that turned out to be ER + PR - HER2 - . Planned on a lumpectomy w rads but went to the BS yest to sign consents for my procedure next week when she informed me it was KI67+ and if invasive would be considered Luminal B type. She offered a mastectomy due to the aggressive nature of this type and high chance of reoccurrence. She suggested genetic testing since I am <45. My ins is reluctant to cover since the only BC in my family is remote. I am trying to get it covered. My question is that I am wondering if anyone else has opted for mastectomy due to bio marker results w DCIS? Did you have genetic testing that also influenced your results?</p>

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  • Beesie
    Beesie Member Posts: 12,240
    edited October 2012

    Do you agree that a mastectomy would be a good idea or would you prefer to stick with the original plan and have a lumpectomy?

    I find your BS's recommendation to be rather odd.  Women with aggressive invasive cancer do just fine with a lumpectomy + rads; the survival rate for a lumpectomy + rads is the same as it is for a mastectomy.  So I don't understand why your BS would recommend a mastectomy based on a possibility that you might have some invasive cancer.  Even if your entire tumor were found to be invasive (which is extremely unlikely), most surgeons would say that a lumpectomy + rads is a perfectly reasonable option. 

    On average about 20% of women with a biopsy diagnosis of DCIS are ultimately found to have invasive cancer.  This risk is greatest for those who have a large area of DCIS and those who have high grade DCIS and/or comedonecrosis.  It doesn't appear that your biopsy diagnosis meets any of these criteria.  So the risk that there may be some invasive cancer hidden with your DCIS is probably 20% at most.   

    If you are not sure that you want the MX or if you know that you would prefer the lumpectomy + rads option, I'd recommend that you get a second opinion. It sounds as though your BS believes in a very aggressive treatment approach.  There are pros and cons to that and it might be helpful to get another perspective.  

    As for genetic testing, being 45 you are considered 'young' for a diagnosis of BC although 45 is right at the top of the age limit for most insurance carriers in terms of approving BCRA testing (i.e. they approve testing if the patient is aged 45 or younger at time of diagnosis). The exception is if there is a family history of breast cancer or related cancers (ovarian, prostate and some others), particularly if those family members were diagnosed under the age of 50. Do you have any family history of these types of cancers?

  • Beesie
    Beesie Member Posts: 12,240
    edited October 2012

    Something to add/clarify....  There have been studies that suggest that DCIS that is Ki67+ does present a higher recurrence risk than DCIS that is not Ki67+.  This doesn't mean however that a mastectomy is necessary.  What it does mean is that if you have a lumpectomy, you probably don't want to pass on rads and you probably want to ensure that the surgical margins are above what's minimally acceptable, i.e. have a re-excision if the margins are too close. 

    http://www.ncbi.nlm.nih.gov/pubmed/22361634

  • lisagwa
    lisagwa Member Posts: 232
    edited October 2012

    I am over the age of 45. My bc dx was 8 months ago. I wanted to have BRCA testing to know the results so that (1) I could decide whether to consider a hysterectomy and (2) I could find out if my daughter would be affected. I was told that most likely it wouldn't be covered by insurance. I was prepared to pay out of pocket and think of it as an investment. It was important for me to know. I must say I was surprised to find out after testing that it was mostly covered. I ended up paying co-pays which wasnt cheap but, for me, was worth it.

    The result was that I didn't have the gene. However, because of bc and infertility meds, I am still seriously considering a hysterectomy.







  • Mcall44
    Mcall44 Member Posts: 18
    edited November 2012

    Thanks for the input. Had a wide resection lumpectomy w reconstruction last Thursday. Fortunately, they got it all and it turned out to be micropapillary and solid intermediate grade with surgical margins .4mm->1cm. I am feeling thankful. Because of the markers, am doing genetic testing and radiation in a couple of weeks prob followed by tamoxifen. Also thankful for the wonderful info on this site.

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